2013 - ISODP 2013 Congress


This page contains exclusive content for the member of the following sections: TTS, ISODP. Log in to view.

Oral Presentation 17 on Graft and Patient Outcomes 2

45.4 - Time to donate: the relationship between the time from declaration of brain death to procurement of organs on liver transplant allograft outcomes

Presenter: Nudrat , Rashid, Sydney, Australia
Authors: Myra Sgorbini, Nudrat Rashid, Oran Rigby

Time to donate: the relationship between the time from declaration of brain death to procurement of organs on liver transplant allograft outcomes

Myra Sgorbini3, Nudrat Rashid1, Oran Rigby2

1Intensive Care Unit, Nepean Hospital, Sydney, Australia, 2Trauma Services, Wagga Base Hospital, Wagga, Australia, 3Intensive Care Service, Royal Prince Alfred Hospital, Sydney, Australia

 

Initial poor graft function (IPGF) following orthotopic liver transplantation (OLTx) is important in prognostication of recipient outcome. A retrospective study was conducted at Sydney’s Royal Prince Alfred Hospital (RPAH) of 47 adult patients who underwent OLTx in 2010 from brain dead donors. The aim of this study was to determine if time from declaration of brain death to organ procurement is a risk factor for IPGF. Data was obtained from medical records maintained by the Australian National Liver Transplant Unit based at RPAH and by accessing the databases kept by the Australia and New Zealand Liver Transplant Registry as well as data held by the Australia and New Zealand Organ Donation Registry. We studied the incidence of IPGF and analysed matched donor parameters to graft outcomes. IPGF was defined based on an aspartate aminotransferase (AST) or an alanine aminotransferase (ALT) of >1500U/ml on two consecutive measurements within the first 72 hours after OLTx, with an elevation lasting for 48 hours. Results show that IPGF occurred in 4 of the 47 patients and there was no significant difference in the mean duration of time from declaration of brain death to organ procurement (15.5 +/- 2.9 hours in IPGF group versus 16.2 +/- 9.2 hours in non-IPGF group, P=0.619). The occurrence of IPGF in the recipient was associated with a significant increased length of stay in the intensive care unit (20.3 +/- 12.8 hours versus 6.4 +/- 5.6 hours, P=0.003). The incidence of IPGF in this study (8.5%) was low as compared to other reports in the literature of up to 23%. The lack of a significant effect may be explained by the fact that this was a relatively small study and therefore underpowered. Additional research is required to further delineate donor factors that contribute to initial poor graft functions after OLTx.


Important Disclaimer

By viewing the material on this site you understand and accept that:

  1. The opinions and statements expressed on this site reflect the views of the author or authors and do not necessarily reflect those of The Transplantation Society and/or its Sections.
  2. The hosting of material on The Transplantation Society site does not signify endorsement of this material by The Transplantation Society and/or its Sections.
  3. The material is solely for educational purposes for qualified health care professionals.
  4. The Transplantation Society and/or its Sections are not liable for any decision made or action taken based on the information contained in the material on this site.
  5. The information cannot be used as a substitute for professional care.
  6. The information does not represent a standard of care.
  7. No physician-patient relationship is being established.

Social

Contact

Staff Directory
+1-514-874-1717
info@tts.org

Address

The Transplantation Society
International Headquarters
740 Notre-Dame Ouest
Suite 1245
Montréal, QC, H3C 3X6
Canada