2014 - Transplant Infectious Disease Conference


Drugs and Devices

5.3 - Vaccine recommendations for the transplant recipient (pre and post transplant). IDSA just published new guidelines

Presenter: Odile, Launay, Paris, France
Authors: Odile Launay


Solid organ transplant (SOT) recipients are at risk of severe infections and prevention of vaccine preventable infections is a challenging question in immunocompromised populations. Despite evidence that inactivated or sub-unit vaccines are safe and effective among immunocompromised hosts, vaccine coverage remains low in these patients. The goal of the IDSA clinical practice guidelines recently published is to provide primary care and specialty clinicians with evidence-based guidelines for active immunization of immunocompromised patients and their household contacts in order to decrease morbidity and mortality from vaccine preventable infections in immunocompromised patients. The presentation will summarize IDSA recommendations for vaccination of SOT candidates and living donors, SOT recipients, and household contacts.
Living donors should be vaccinated according to the CDC annual schedule but live attenuated vaccine administration should be avoided within 4 weeks of organ donation. Vaccination of living donors solely for the recipient’s benefit is not recommended.

Because response to vaccinations is decreased in patients with end-stage organ disease and in the first 2 to 6 months after transplantation, the vaccines should be given before transplantation, as early as possible during the course of disease and avoided during the 2 to 6 months after transplantation. However, inactivated influenza vaccine can be administered from 1 month after transplantation. Vaccination should not be withheld because of concern about transplant organ rejection.

Live attenuated vaccines should be avoided in solid-organ transplantation recipients. If necessary, they have to be administered at least 4 weeks before transplantation excepted in patients receiving immunosuppression.
Vaccination strategy should include vaccination of household contacts and health care workers at transplant centers.


You must be logged in to view recordings

Important Disclaimer

By viewing the material on this site you understand and accept that:

  1. The opinions and statements expressed on this site reflect the views of the author or authors and do not necessarily reflect those of The Transplantation Society and/or its Sections.
  2. The hosting of material on The Transplantation Society site does not signify endorsement of this material by The Transplantation Society and/or its Sections.
  3. The material is solely for educational purposes for qualified health care professionals.
  4. The Transplantation Society and/or its Sections are not liable for any decision made or action taken based on the information contained in the material on this site.
  5. The information cannot be used as a substitute for professional care.
  6. The information does not represent a standard of care.
  7. No physician-patient relationship is being established.

Our Corporate Sponsors

TTS gratefully acknowledges the Corporate Partners whose generous support makes the work of the Society possible:

  • astellas
  • roche
  • sanofi