2010 - TTS International Congress
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Complications Cardiovascular
31.10 - Comparison of heart rate variability between patients on kidney transplantation and hemodialysis due to end stage renal disease in Korea.
Presenter: JOONGKYUNG, KIM, BUSAN, Korea
Authors: KIM J., Oh J., KIM S., Shin Y., Huh K.
COMPLICATIONS - CARDIOVASCULAR
J.S. Oh1, J. Kim2, S. Kim2, Y.H. Shin3, K. Huh4
1Divison Of Nephrology, Internal Medicine, Bong Seng hospital, Busan/KOREA, 2Division Of Nephrology, Internal Medicine, Bong Seng Hospital, BUSAN/KOREA, 3Division Of Nephrology, Internal Medicine, Bong Seng Hospital, Busan/KOREA, 4General Surgery, Bong Seng Hospital, Busan/KOREA
Body: Introduction : Heart rate variability (HRV) can be used to assess the effects of drug and other interventions including respiration, exercise, metabolic change and psychological or physical stress on cardiac autonomic tone. HRV is regulated by the balance of sympathetic and parasympathetic tones. Few studies about HRV in patients with kidney transplantation were performed in Korea. So, authors investigate the autonomic nerve system activity by HRV in patients with kidney transplantation. Methods : We compared the pattern of cardiac sympathetic and parasympathetic activity through the time- and frequency-domain analysis of HRV with 24-hour Holter monitoring between 32 kidney transplanted subjects and 30 control patients with hemodialysis due to end stage renal disease. The subjects have been received kidney transplantation at the Bongseng hospital between January 2007 and December 2009. Results : The mean age of subjects and controls were 58.22 ± 13.72 and 51.17 ± 11.91 years-old respectively. In subject group, all time- and frequency-domain HRV measures including HRV index, very low-frequency (VLF), normalized unit of low-frequency (LFnorm) and ratio of low-frequency power to high-frequency power (LF/HF) were increased compared with control group. Conclusion : Autonomic tones in patients with kidney transplantation are increased compared with those in patients with hemodialysis due to end stage renal disease. And sympathetic tones in KTP patients have the preponderance over parasympathetic tones. Kidney transplantation may be a modality to improve HRV index in patients with ESRD.The comparison of time & frequency-domain HRV measures between groups
| KTP patients | HD patients | p value | |
| HRV index | 16.40 ± 5.55 | 11.72 ± 5.70 | 0.01 |
| VLF, msec2 | 995.46 ± 1936.52 | 153.40 ± 180.66 | 0.03 |
| LF norm, nu | 44.55 ± 21.25 | 33.35 ± 20.35 | 0.03 |
| LF/HF | 2.56 ± 2.53 | 1.14 ± 1.08 | 0.01 |
Disclosure: All authors have declared no conflicts of interest.
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