EPIDEMIOLOGY AND CLINICAL OUTCOMES

Y. Reddy¹, Y. Reddy², N. Fathima², G. Abraham^2
1Nephrology, Madras Medical Mission, Chennai/INDIA, ²Dialysis And Renal Transplantation, Madras Medical Mission, CHENNAI/INDIA

Body: Introduction: Anemia is a well known complication of chronic kidney disease due, at least in part, to decreased erythropoietin secretion by the diseased kidney. This prospective observational study was undertaken to compare the efficacy of three different erythropoietin regimes for raising hemoglobin following renal transplantation. Materials and methods: The charts of 77 patients transplanted between 2006 and 2009 in a tertiary care institution were retrospectively collected. Group A received Mircera (100 mcg stat s/c) (n=25), Group B received Epoetin 10000 units on the first,third and eight day(n=26) and Group C received Epoetin 2000 units twice a week(n=26). Baseline demograhic variables and hemoglobin were collected before transplantation and a month after transplantation. Results: Hb in group A fell from 10.8+1.8 g/dl before transplantation to 9.4+2.0 g/dl one month after transplantation with a mean fall of 1.4(p=0.05). Hb in group B was 9.5+1.5 g/dl before transplantation and was 9.6+2.1g/dl one month after transplantation with a mean rise of 0.14 (p=.746). Hb in group C was 9.5+1.7 g/dl before transplantation and 9.5+1.6 g/dl one month after transplantation with a mean rise of 0.1 (p=.973). Conclusion: Mircera was not as efficacious as Epoetin 10000 on the first, third and eight day or Epoetin 2000 twice a week in raising Hemoglobin 1 month after renal transplantation. There was no significant difference between Epoetin 10000 and Epoetin 2000. (p=.988)

Disclosure: All authors have declared no conflicts of interest.