Wednesday, November 22, 11am EST - Epitope Matching: What is it, and what is its relevance?

Wednesday, November 22, 2017, 11am EST (Montreal time) - Peter Nickerson

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Trainee Track Webinar Wednesday, November 22, 2017

Trainee Track Webinar
Epitope Matching: What is it, and what is its relevance?
Wednesday, November 22, 2017, 11am EST (Montreal time)


Peter Nickerson, BSc (Med), MD, FRCPC, FCAHS
Distinguished Professor of Internal Medicine and Immunology
Vice-Dean of Research
Rady Faculty of Health Sciences
University of Manitoba
Medical Director of Transplant Manitoba and Medical Advisor
Organ Donation and Transplantation Division
Canadian Blood Services
Winnipeg, Manitoba, Canada

Peter Nickerson, BSc (Med), MD, FRCPC, FCAHS


Robert Liwski, MD, PhD, FRCPC
Medical Director, HLA Typing Laboratory
Staff Hematopathologist, Division of Hematopathology
Queen Elizabeth II Health Sciences Centre
Professor, Departments of Pathology and Microbiology & Immunology
Dalhousie University
Halifax, Nova Scotia, Canada

Robert Liwski, MD, PhD, FRCPC


Adequacy of immunosuppression is central to holding the alloimmune response in check. Clinicians and patients constantly seek to lower immunosuppressive therapy to minimize the risk for serious adverse events or avoid annoying side-effects leading to clinician-guided under immunosuppression and patient nonadherence. Unfortunately, at present there is no validated predictive biomarker to inform clinicians who can and cannot be safely minimized. The risk of minimization is de novo DSA resulting in antibody-mediated rejection, transplant glomerulopathy and premature graft failure. Moreover, once this process is underway, at present physicians have no effective therapy to turn it off. In the last few years it has been appreciated that computational approaches predicting potential antibody binding epitopes on the mismatched donor and the recipient HLA molecules can be used to predict alloimmune risk for de novo DSA, late acute rejections and graft failure. If this is further validated, then we may have for the first time a predictive biomarker able to aid clinicians safely personalize immunosuppressive therapy.

Peter Nickerson - Biography:

Dr. Peter Nickerson is a Distinguished Professor of Internal Medicine and Immunology and the Vice-Dean Research, Rady Faculty of Health Sciences at the University of Manitoba. He is the Medical Director of Transplant Manitoba and the Medical Advisor, Organ Donation and Transplantation Division, Canadian Blood Services (CBS).

Dr. Nickerson holds the Flynn Family Chair in Renal Transplantation at the University of Manitoba. Funded by the CIHR and NIH, his research program focuses on mechanisms underlying acute and chronic transplant rejection; developing non-invasive techniques for the diagnosis of renal allograft rejection; and health care system design to enhance access to transplant.

Robert Liwski - Biography:

Dr. Liwski obtained his PhD in Transplantation Immunology in 1999, his MD degree in 2003 and completed his fellowship training in Hematological Pathology in 2006, all at Dalhousie University. His research interests include transplantation immunology, ischemia reperfusion injury and optimization of diagnostic testing in transplantation. Dr. Liwski has developed several optimized HLA antibody testing methods including the Halifax/Halifaster flow crossmatch protocols and the Rapid Optimized Single Antigen Bead (ROB) assay. He was awarded the Canadian Association of Pathologists Junior Scientist Award for his research investigating the role of activated protein C in prevention of ischemia reperfusion injury and cancer metastasis.

Wednesday, November 22, 2017, 11am EST (Montreal time)

AccraWed 16:00CasablancaWed 16:00KolkataWed 21:30ReykjavikWed 16:00
Addis AbabaWed 19:00ChicagoWed 10:00Kuala LumpurThu 00:00Rio de Janeiro *Wed 14:00
Adelaide *Thu 02:30CopenhagenWed 17:00Kuwait CityWed 19:00RiyadhWed 19:00
AlgiersWed 17:00DallasWed 10:00KyivWed 18:00RomeWed 17:00
AlmatyWed 22:00Dar es SalaamWed 19:00La PazWed 12:00Salt Lake CityWed 09:00
AmmanWed 18:00DarwinThu 01:30LagosWed 17:00San FranciscoWed 08:00
AmsterdamWed 17:00DenverWed 09:00LahoreWed 21:00San JuanWed 12:00
AnadyrThu 04:00DetroitWed 11:00Las VegasWed 08:00San SalvadorWed 10:00
AnchorageWed 07:00DhakaWed 22:00LimaWed 11:00Santiago *Wed 13:00
AnkaraWed 19:00DohaWed 19:00LisbonWed 16:00Santo DomingoWed 12:00
AntananarivoWed 19:00DubaiWed 20:00LondonWed 16:00São Paulo *Wed 14:00
Asuncion *Wed 13:00DublinWed 16:00Los AngelesWed 08:00SeattleWed 08:00
AthensWed 18:00EdmontonWed 09:00MadridWed 17:00SeoulThu 01:00
AtlantaWed 11:00FrankfurtWed 17:00ManaguaWed 10:00ShanghaiThu 00:00
Auckland *Thu 05:00Guatemala CityWed 10:00ManilaThu 00:00SingaporeThu 00:00
BaghdadWed 19:00HalifaxWed 12:00Melbourne *Thu 03:00SofiaWed 18:00
BangaloreWed 21:30HanoiWed 23:00Mexico CityWed 10:00St. John'sWed 12:30
BangkokWed 23:00HarareWed 18:00MiamiWed 11:00StockholmWed 17:00
BarcelonaWed 17:00HavanaWed 11:00MinneapolisWed 10:00Suva *Thu 05:00
BeijingThu 00:00HelsinkiWed 18:00MinskWed 19:00Sydney *Thu 03:00
BeirutWed 18:00Hong KongThu 00:00MontevideoWed 13:00TaipeiThu 00:00
BelgradeWed 17:00HonoluluWed 06:00MontréalWed 11:00TallinnWed 18:00
BerlinWed 17:00HoustonWed 10:00MoscowWed 19:00TashkentWed 21:00
BogotaWed 11:00IndianapolisWed 11:00MumbaiWed 21:30TegucigalpaWed 10:00
BostonWed 11:00IslamabadWed 21:00NairobiWed 19:00TehranWed 19:30
Brasilia *Wed 14:00IstanbulWed 19:00NassauWed 11:00TokyoThu 01:00
BrisbaneThu 02:00JakartaWed 23:00New DelhiWed 21:30TorontoWed 11:00
BrusselsWed 17:00JerusalemWed 18:00New OrleansWed 10:00VancouverWed 08:00
BucharestWed 18:00JohannesburgWed 18:00New YorkWed 11:00ViennaWed 17:00
BudapestWed 17:00KabulWed 20:30OsloWed 17:00WarsawWed 17:00
Buenos AiresWed 13:00KarachiWed 21:00OttawaWed 11:00Washington DCWed 11:00
CairoWed 18:00KathmanduWed 21:45ParisWed 17:00WinnipegWed 10:00
CalgaryWed 09:00KhartoumWed 18:00PerthThu 00:00YangonWed 22:30
Canberra *Thu 03:00KingstonWed 11:00PhiladelphiaWed 11:00ZagrebWed 17:00
Cape TownWed 18:00KinshasaWed 17:00PhoenixWed 09:00ZürichWed 17:00
CaracasWed 12:00KiritimatiThu 06:00PragueWed 17:00

* = Adjusted for DST or summer time (11 places).
Wed = Wednesday, November 22, 2017 (123 places).
Thu = Thursday, November 23, 2017 (20 places).
UTC (GMT/Zulu)-time: Wednesday, November 22, 2017 at 16:00:00
UTC is Coordinated Universal Time, GMT is Greenwich Mean Time.

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