IN THE NEWS - VOLUME 1 - ISSUE 9 - May 6, 2015

Donor Kidneys Usable Despite Acute Kidney Injury
May 5 - PHILADELPHIA—Transplanted kidneys from deceased donors with acute kidney injury (AKI) are associated with patient and graft survival rates similar to those of non-AKI deceased-donor kidneys, according to study findings presented at the 2015 American Transplant Congress. [more]

New hope for short bowel syndrome - Scientists make a fully-functional small intestine
May 4 - Bethesda - Researchers at Children’s Hospital Los Angeles have successfully made a small intestine that has the structural and molecular components of a healthy intestine. [more]

Post-Transplant Renal Function Decline Predicts Worse Outcomes
May 5 - PHILADELPHIA - A 30% or greater decline in estimated glomerular filtration rate (eGFR) between years 1 and 3 after kidney transplantation is associated with an increased risk of graft-censored graft failure and patient death, data presented at the 2015 American Transplant Congress suggest. [ more]

New clues into how stem cells get their identity
May 6 - UNIVERSITY OF COPENHAGEN - Scientists at the University of Copenhagen have identified one mechanism that explains how some stem cells choose to become a given cell type: the cells combine specific sets of proteins at precise positions along the DNA. When these particular groups of proteins are combined, the gates are opened so that certain groups of genes can now be used, giving the cells a new identity. [more]

Immunotherapy Protects Against CMV After Cord Blood Transplant
May 5 - Science Translational Medicine - A novel adoptive immunotherapy offers a way to protect against potentially lethal cytomegalovirus (CMV) infection after hematopoietic stem cell transplant from umbilical cord blood or CMV-seronegative adult donors, hint the results of a phase 1 pilot study. [more]

Study: Generic transplant drugs as good as brand name
May 4 - PHILADELPHIA = A University of Cincinnati (UC)-led research team has found that generic formulations of tacrolimus, a drug used post-transplant to lower the risk of organ rejection, are just as good as the name-brand version. [more]

Stanford stem cell experts highlight “inherent flaw” in drug development system
May 1 - Academic institutions are in a much better position than pharmaceutical companies to make the best decisions about which therapies deserve further development. That was the underlying message from a pair of Stanford researchers at a panel on stem cell science at last weekend ’s Association of Health Care Journalism 2015 conference. [more]

ALLY-1 Clinical Trial Results Suggest Viable Chronic Hepatitis C Virus Treatment
April 30 - Study results promising for hepatitis C patients awaiting or completing liver transplant. [more]

Encapsulated Stem Cells Could Accelerate Wound Healing
May 4 - Cornell - A team of Cornell University scientists has shown that equine stem cells confined inside tiny capsules secrete substances that help heal simulated wounds in cell cultures, opening up new ways of delivering these substances to the locations in the body where they can hasten healing. The capsules need to be tested to see if they help healing in live horses, but they could eventually lead to “living bandage” technologies, wound dressings embedded with capsules of stem cells to help the underlying wound regenerate. [more]

Survival worse in lung recipients of donors with diabetes
May 6 - SEATTLE — Patients who received a single lung transplantation from a donor with diabetes were at a significantly increased risk for mortality compared with lung recipients of donors without diabetes, according to data presented at the American Association for Thoracic Surgery Annual Meeting. [ more]

Stem Cells Transplanted, Followed in Brain
May 1 - Investigators at the Stanford University School of Medicine have devised a way to monitor neural stem cells after they’ve been transplanted into the brain. [more]

Melbourne researchers working on machine to keep donor livers functioning
May 6 - Melbourne researchers have created a machine that keeps a donor liver functioning after being removed from the body, which could assist in transplants. Austin Health liver transplant surgeon Graham Starkey said the machine acted like an "artificial lungs and heart" to keep the liver working, and could buy surgeons vital time to assess whether the organ is transplantable. "Really what the machine tries to do is mimic nature," he said. [more]

Bioengineer takes an evolutionary approach to viral drug delivery vehicles
April 27 - "We're fighting biology and evolution," Schaffer says. The viruses must also reach the right cell type among many within a tissue, and in sufficient numbers to deliver its gene cargo. The challenges have stalled gene therapy from its outset. [more]

Polish doctors perform throat transplant
May 5 - The patient, a 37-year old man, suffered from an advanced stage of cancer in his voice box. This made it impossible for the man to breath, swallow or speak, said Dr. Adam Maciejewski, the surgeon behind the procedure. [more]

Weaning Transplant Patients from Immunosuppressive Drugs
April 25 - About half the patients taking immunosuppressive drugs to keep their bodies from rejecting organ transplants could be weaned from this regimen, according to researchers in Germany. [more]

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