Heart and Lung Xenotransplantation

A Xenotransplantation Advisory Committee lead by the president of the International Society for Heart and Lung Transplantation (ISHLT), Robert Kormos, considered the status of xenotransplantation and its potential role in the future treatment of patients with end-stage cardiac and pulmonary diseases in a global context. In particular, members considered the need for a new source of thoracic organs for transplantation, the potential of xenotransplantation to fulfill this need in comparison with other therapeutic modalities, the immune barriers and potential complications of clinical xenotransplantation, and some ethical, regulatory, and financial aspects. A position paper Report of the Xenotransplantation Advisory Committee of the International Society for Heart and Lung Transplantation: The Present Status of Xenotransplantation and Its Potential Role in the Treatment of End-Stage Cardiac and Pulmonary Diseases was published in Xenotransplantation in 2000. The authors emphasized that the field of xenotransplantation research, particularly that involving thoracic-organ transplantation, should be reviewed at intervals and revisions made to their conclusions and recommendations.