tts2018program

The Transplantation Society is a non-profit NGO providing global leadership in transplantation. Our core mission include the development of the science and clinical practice, scientific communication, continuing education and guidance on the ethical practice.

Subscribe to Tribune PulseView PAST ISSUES

header1bj7

Transplantation Journal - Vol. 4, No. 6, June 2018

txjournal2

The June issue of Transplantation Direct contains articles and communications on a variety of topics in transplantation. Among the topics reported in kidney transplantation are the interim results of the Amsterdam, LEden, GROningen randomized trial testing immunosuppression minimization (steroids/tacrolimus) in over 300 patients. A study from the UK assesses the value of low clearance transplantation clinics that support the management of recipients with failing kidney transplants. In liver transplantation, a large Eurotransplant-data-based study examines the impact of organ implantation time on outcomes, and an interesting case control study looks at the association of DSA development on late-onset PTLD. In the area of infectious disease research in organ and stem cell transplant recipients, the meaning of CMV PCR "blips" is examined and the implications discussed. Organ donation issues are also addressed in this Direct issue. The Canadian National Transplant Research Program reports on their survey results defining future research priorities in organ and stem cell donation. Also, a Living Organ Video Educated Donors (LOVED) program aims to address living donor kidney transplantation disparities in African Americans; the results and impact of this program are reported on here. We hope that you find this content interesting and useful, and look forward to future contributions from your group.

CLICK TO READ THE FULL ARTICLE

Study Seeks to Improve Kidney Transplant Outcomes

1527692094136

From left, Liise K. Kayler, MD; John Reinier F. Narvaez, MD (He will be presenting at TTS 2018, click for presentation details); and medical student Kevin Espino have published a study on using enhanced recovery after surgery protocols to improve kidney transplant patient outcomes.

May 30 - Improving outcomes for kidney transplant patients is the goal of newly published research led by Liise K. Kayler, MD, clinical professor of surgery.

CLICK HERE FOR DETAILS

Hard-to-Treat Infections May Not Impact Survival of CF Patients After Lung Transplant, Study Shows

One-year survival after a lung transplant of cystic fibrosis (CF) patients chronically infected with antibiotic-resistant bacteria is similar to those without infections, according to a retrospective analysis of data from the International Society of Heart and Lung Transplantation (ISHLT) Thoracic Transplant Registry.

CLICK HERE FOR DETAILS

Understanding immune system interplay to improve organ transplant success

23 understandin

Credit: Babraham Institute

May 31 - A rare opportunity to analyse both blood and tissue samples from human transplant recipients has allowed immunology researchers at the Babraham Institute to pinpoint how an immunosuppressive drug works to prevent the production of antibodies against the transplanted tissue.

CLICK HERE FOR DETAILS

LOng-TIME TTS MEMBER, Robert S. Gaston honored with  Lifetime Achievement Award

Robert S GastonThe Transplantation Society congratulates Dr. Gaston on behalf of all his fellow TTS members.

Dr. Gaston is a nephrologist who has dedicated more than 30 years to medicine was awarded with the highest honor that the AST bestows – the Lifetime Achievement Award. In addition to his broad experience in hypertension, immunology, public policy, and solid organ transplantation, much of Dr. Gaston's work has focused on drug development to address the challenge of improving long-term graft survival in kidney transplant recipients. He has been involved in clinical investigation since the 1990s, with research funded by industry, foundation, and government, and he has authored more than 300 published articles, chapters, and abstracts. Dr. Gaston's expertise is nationally recognized and has resulted in ongoing consultation for the National Institutes of Health (NIH), US Food and Drug Administration (FDA), several academic institutions, and industry (biotech and large pharma).

Pig organs for human patients: A challenge fit for CRISPR

May 30 - Through a new license, Harvard lab's innovations in genome engineering might solve the organ transplant shortage

Luhan horizontal 650 sm 632 421

Co-founded by Professor George Church and former HMS doctoral student Luhan Yang, Ph.D. (pictured), eGenesis has exclusive access, in the field of xenotransplantation, to foundational intellectual property (IP) on CRISPR, as well as certain subsequent innovations. The license includes IP relating to the Church Lab's 2012 breakthrough use of CRISPR, led by Yang and Prashant Mali, Ph.D., to edit the genome of human cells. (Photo courtesy of eGenesis.)

Over the past few years, researchers led by George Church, Ph.D., the Robert Winthrop Professor of Genetics at Harvard Medical School (HMS) and a Core Faculty Member of Harvard's Wyss Institute for Biologically Inspired Engineering, have made important strides toward engineering the genomes of pigs to make their cells compatible with the human body. A healthy heart for a patient in desperate need might one day come from a pig.

CLICK HERE TO READ THE FULL ARTICLE 


IXA long 60ebf27eDon't miss our July 1 Pre-Congress Workshop @TTS 2018
Xenotransplantation - Advancing to the Clinic

The field of xenotransplantation has made significant progress over the last 5 years, with cell and organ graft survival in large animal models reaching almost 3 years. The aim of the workshop is to present the most recent advances and the outlook for the first clinical trials.

CLICK HERE TO SEE ALL AVAILABLE WORKSHOPS AT TTS2018 

UK - Case Study: DHSC's 'opt-out' organ donation consultation campaign attracts 17,000 responses

DHSC614 2018053010324417

DHSC targeted families with campaign for consultation on organ donor opt-in

May 30 - Health comms specialists have been challenged to encourage people to open up about a subject many are unwilling to face - whether or not to donate their organs, or those of their loved ones, after their death.

CLICK HERE FOR DETAILS


closing


Researchers find secret of newt species' amazing regeneration

newt
Japanese fire belly newt (cynops pyrrhogaste) (Provided by Chikafumi Chiba)

A type of Japanese newt can regrow its tail, eyes, brain and even parts of its heart throughout its lifetime thanks to a specific type of red blood cell, a Japanese research team has found.

CLICK TO READ THE FULL ARTICLE

The promise of regenerating tissues and organs from inside the body

3 layer 2
A three-layered sphere created in the Lim Lab by programming synNotch receptors on groups of cells.
(Wendell Lim/UC San Francisco)

June 1 - Regenerative medicine holds tremendous promise for many ailments, from curing diabetes with pancreatic cell transplants to growing new organs for transplant. But because these approaches generate tissue ex vivo, or outside the body, scientists developing them all face the same conundrum: How can they connect these externally developed tissues to the bloodstream and the rest of the body so they can thrive?

CLICK HERE TO READ THE FULL ARTICLE


Transplantation - Featured Article

Submitted by Dr Karen Keung, Editorial Fellow, Transplantation.

Reduced TCR Signaling Contributes to Impaired Th17 Responses in Tolerant Kidney Transplant Recipients. 
Nova-Lamperti E, Romano M, Christakoudi S, et al.
Transplantation. 2018;102(1):e10-e17

The development of operational tolerance in transplantation has been demonstrated to be associated with a numerous B cell related immune alterations, whilst the role of other lymphocyte subsets is less clear. In this study, CD4+ T cells from tolerant kidney transplant recipients (n = 17) were compared with those from patients with chronic rejection (n = 32) and healthy volunteers (n = 12) assessing their gene expression profile, phenotype and function upon activation. Tolerant patients were found to possess fewer Th17 cells, exhibited reduced Th17 responses after CD3/28 activation, and reduced TCR signaling which was linked with a decrease in IL-17 production by CD4+ T cells.
The authors have presented some novel evidence suggesting that incomplete Th17 pathway integrity may help facilitating clinical tolerance.

READ MORE

Timing is everything to build kidneys from scratch

June 4 - Researchers show stem cells fashion kidney functions based on when they converge

180604112535 1 540x360
Developing human nephron, the filtering unit of the kidney.
Credit: Image by Nils O. Lindstrom and Tracy Tran/McMahon Lab USC Stem Cell

Perfectly punctual or fashionably late, it takes all kinds to build a kidney. So it is for stem cells building kidney tissue discovered timing is critical as the precise arrival of progenitor cells dictates their form and function in the kidney. The finding will help fabricate kidney components for use in drug tests and treatment of renal disease.

CLICK HERE TO READ THE FULL ARTICLE


In the News

New approach could grow materials that exactly mimic bone or dental enamel

June 3 - A team of researchers, led by scientists at the Queen Mary University of London, has uncovered a new approach to grow synthetic mineralized materials. This exciting breakthrough points to a future of regenerative medicine where doctors could mimic the regrowth of hard tissues including dental enamel and bone.

CLICK TO READ THE FULL ARTICLE


Cell Transplant Trial for Spinal Injury Is Safe

June 1 - Four patients with chronic spinal damage and a complete loss of motor and sensory functions below their waists have received transplants of human neural stem cells in a first-of-its-kind clinical trial.

CLICK HERE TO READ THE ARTICLE


PAKSITAN - Kidney transplantation facility soon

June 7 - Deputy Commissioner Zahid Suhail said that kidney transplantation would begin soon at the recently established Kidney centre. He said this during his visit to the Kidney and Regional Blood centre here on Wednesday. The deputy commissioner inspected operation theater and outdoor of the health centre

READ THE FULL ARTICLE

Post-Transplant Tx Reduces Wait for Kidney in Hep C+ Patients

June 7 - Delaying treatment until after transplant doesn't adversely impact kidney allograft or survival.

READ THE FULL ARTICLE

First UK womb transplant 'by end of 2018'

June 5, 2018 - The surgeon planning to do the first womb transplant in the UK says he hopes to carry out the first operations "before the end of 2018".

READ THE FULL ARTICLE

Subscribe to Tribune PulseView PAST ISSUES

header1b31

This Handheld Device Could Print New Skin Onto Burn Victims

2018 05 02 skin 3d

Researchers have long been looking for methods of creating artificial skin grafts, either from biological or synthetic materials. There are a number of such products on the market, but they have limitations: some are expensive, some can only be used temporarily, some take weeks to create from the patient’s own skin cells. The University of Toronto researchers developed a printer the size of a shoe box, weighing less than one kilogram (2.2 pounds). It dispenses strips of “bio ink” made of biological materials. These materials include collagen—the most abundant protein in the dermis, or middle layer of the skin—and fibrin, a protein needed for wound healing. The strips of artificial skin can be deposited directly on the injured area.

CLICK TO READ THE FULL ARTICLE

These cells turn lung transplants deadly

Researchers have uncovered the precise cells that flow into and cause inflammation in newly transplanted lungs.

CLICK HERE FOR DETAILS

Understanding immune system interplay to improve organ transplant success

A rare opportunity to analyse both blood and tissue samples from human transplant recipients has allowed immunology researchers at the Babraham Institute to pinpoint how an immunosuppressive drug works to prevent the production of antibodies against the transplanted tissue. This understanding, gained through working together with transplant research immunologists in Oxford, may lead to improved ways of identifying transplant recipients at risk of rejection and treating autoimmune disease.

CLICK HERE FOR DETAILS

Baby Born in World's First In Utero Stem Cell Transplant Trial

May 25 - An in utero stem cell transplant for a critically ill second-trimester fetus has led to the birth of an apparently healthy infant. The newborn is the first patient enrolled in the world's first clinical trial using stem cells transplanted prior to birth.

in utero stem cell transplant family 1

CLICK HERE TO READ THE FULL ARTICLE 

U.S. DRUG OVERDOSES MEAN MORE ORGANS FOR TRANSPLANTATION, HARVARD STUDY SHOWS

May 30 - The opioid epidemic ravaging the U.S. is killing tens of thousands a year, with over 63,600 overdose deaths in 2016. Although opioid prescriptions have started falling, the crisis is not abating. When pills aren't available, many users turn to heroin or its more dangerous cousin, fentanyl. But a strange phoenix has risen from these ashes: life-saving organs available for transplantation. After Mandeep Mehra and a colleague at Harvard Medical School noticed an increase in the number of donors, they tracked the source to opioid-related deaths. Newsweek spoke with Mehra, a professor of medicine, about the discovery of this disconcerting correlation.

CLICK HERE TO READ THE FULL ARTICLE

Don't Miss our 10th Anniversary of the Declaration of Istanbul @ TTS2018

DICG Logo

This workshop will comprise a half-day morning program addressing common ethical and clinical dilemmas in the management of organ donation and transplantation cases that may involve organ trafficking, and a half-day afternoon program exploring the update to the Declaration of Istanbul on Organ Trafficking and Transplant Tourism in the context of persisting and emerging issues in this field.

CLICK HERE FOR DETAILS


closing


Jayme Locke, TTS Young Members Committee Co-CHair wins ACTS Distinguished Investigator Award

locke

May 23 - The honor, received by Jayme Locke in April at the Association for Clinical and Translational Science Conference in Washington, D.C., is presented to a senior investigator whose innovative research or education leadership has had a major impact on or through clinical and translational science, specifically in applying translational research findings into effective public policies that promote health.

CLICK TO READ THE FULL ARTICLE

Researchers Want To Show HIV-Positive Organ Donation Is Safe And Can Save Lives

A large-scale clinical trial launched by the National Institutes of Health in May could pave the way for more HIV-positive patients with kidney disease to receive life-saving transplants.

The trial, called the HOPE in Action Multicenter Kidney Study, will assess the risks of transplanting kidneys from HIV-positive donors into patients living with the virus, says Dr. Christine Durand, assistant professor of medicine at Johns Hopkins University and a principal investigator of the study.

CLICK HERE TO READ THE FULL ARTICLE

NIH Blog - Seven More Awesome Technologies Made Possible by Your Tax Dollars

May 31 - We live in a world energized by technological advances, from that new app on your smartphone to drones and self-driving cars. As you can see from this video, NIH-supported researchers are also major contributors, developing a wide range of amazing biomedical technologies that offer tremendous potential to improve our health.

CLICK HERE TO READ THE FULL ARTICLE

Transplantation - Featured Article

Submitted by Dr Karen Keung, Editorial Fellow, Transplantation.

Terasaki Epitope Mismatch Burden Predicts the Development of De Novo DQ Donor-Specific Antibodies and are Associated With Adverse Allograft Outcomes
Willicombe M, Blow M, Santos-Nunez E, Freeman C, Brookes P, Taube D.
Transplantation. 102(1):127-134

In predicting the development of de novo donor specific antibodies (DSA), recent data suggests that matching at the epitope level is superior to matching at the antigen level. HLA DQB1 antibodies are the most common de novo donor-specific antibodies (DSA) detected postrenal transplantation. In this retrospective study of renal transplant recipients, the authors compared the immunogenicity of the different HLA antigens, individual DQB1 alleles, and DQB1 Terasaki-defined Epitopes (TerEp), to determine whether DQ epitopes determined by Terasaki could more accurately predict de novo DQ development over HLA antigen matching (n=1003, mean follow up 4.28 ± 2.18 years posttransplant); 198 (19.74%) kidney transplant recipients developed de novo DSA of which 88 (44.4%) developed a DSA against a DQB1 mismatched antigen. In patients mismatched at a single DQB1 allele, the risk of de novo DQ DSA development increased with the number of TerEp mismatches, although the immunogenicity of the different DQ TerEps did not appear to be equal. Antibody mediated rejection-free survival was inferior in all patients with an antibody against TerEp epitopes. These data show that epitope mismatch burden determined by TerEps helps predict risk of de novo DQ DSA development and offers an alternative approach to predict an alloimmune response, which can further aid immunologic risk assessment.

READ MORE

A 'wake-up call' about what's killing America's young people

(CNN)There has been a significant rise in accidental deaths, homicides and suicides among young people across the United States, and experts are calling it a wake-up call. The total death rate for 10- to 19-year-olds in the United States declined 33% between 1999 and 2013 but then suddenly soared 12% between 2013 and 2016, according to a new report from the National Center for Health Statistics at the US Centers for Disease Control and Prevention.

CLICK HERE TO READ THE FULL ARTICLE 


amanda


In the News

Precision medicine taking the individual's whole genome into consideration

May 25 - Precision medicine has the potential to transform drug therapy and patients' lives. A recent study published in Human Genomics brings us closer to unlocking that potential.

CLICK TO READ THE FULL ARTICLE


Indy 500 drivers don't like to talk about organ donation, but it's becoming their cause

May 24 - At the Indianapolis Motor Speedway Stefan Wilson's race car trumpets from its sidepods, its prime patch of advertising space, in bold letters: "Driven 2 Save Lives." It's a slogan of the Indiana Donor Network, one of Wilson's chief sponsors. The aim is to encourage people to register as organ donors.

CLICK HERE TO READ THE ARTICLE


Pulmonary Hypertension Has Adverse Effect on Post-Lung Transplant Survival

May 25 - Pulmonary hypertension (PH) confirmed by preoperative cardiac catheterization is associated with the prognosis of Asian patients after lung transplantation for end-stage lung disease, according to the results of a study published in the Journal of Thoracic Disease.

READ THE FULL ARTICLE

Official Sections of The Transplantation Society

cts