The Transplantation Society is a non-profit NGO providing global leadership in transplantation. Our core mission include the development of the science and clinical practice, scientific communication, continuing education and guidance on the ethical practice.

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Transplantation Journal November Issue

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This issue is packed with outstanding papers, reviews, and commentaries. The highlight is the 2018 complete guide to Banff renal allograft pathology. For the first time you don't have to read multiple papers to work out the current Banff scoring system—laid out with excellent illustrations. Antifungal agents are advancing as fast as one can read the papers so here is a review to help. A guide to donor derived viruses in liver transplantation answers many questions. The issue also has much to offer for VCA, cardiac, and renal transplantation. A must read issue.

LINK TO THE ISSUE

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Webinar Announcement - Liver Series on 
"TRENDS AND CHALLENGES IN LIVER TRANSPLANTATION"

6th

TRIAGE FOR SIMULTANEOUS LIVER KIDNEY TRANSPLANTATION AND CLINICAL PEARLS TO OPTIMIZE RENAL PROTECTION AFTER LIVER TRANSPLANTATION

NOVEMBER 6, 2018 - 2 PM EST (MONTREAL TIME)

Click here for full details and to sign up

  Organizer: Sukru Emre, MD
Professor of Surgery (Transplant) and of Pediatrics, Yale University
New Haven, CT, USA
   Moderator: Marcelo Cantarovich, MD
Professor, Department of Medicine, Division of Nephrology, Faculty of Medicine, McGill University
Montréal, QC, Canada
  Discussant: Annmarie Huysman Liapakis, MD
Assistant Professor of Medicine (Digestive Diseases), Yale School of Medicine
New Haven, CT, USA
   Discussant: Clifford D. Miles, MD, MS, FAST
Associate Professor of Internal Medicine
University of Nebraska Medical Center
Omaha, NE, USA

 

TTS-ILTS PAIRED TRANSPLANT CENTERS PROGRAM
Deadline January 1, 2019

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The deadline to submit an application is JANUARY 1, 2019

The TTS-ILTS Paired Transplant Centers Program is a collaboration between The Transplantation Society (TTS) and the International Liver Transplantation Society (ILTS) supporting new liver transplant programs in emerging countries.

TTS-ILTS program advertisement and question request: Please submit any questions you have about the program or the application process to This email address is being protected from spambots. You need JavaScript enabled to view it. .

Visit www.tts-ilts.org for full detail

Education Committee Question for physicians

The Education Committee - WTGF working group wants to know what resources are currently at physicians disposal to assist patients stay physically active post transplant? Are there any current standard practices within your institution? Please let us know by emailing This email address is being protected from spambots. You need JavaScript enabled to view it. .

TRANSPLANTATION JOURNAL - HIGHLIGHTED ARTICLE

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A 2018 Reference Guide to the Banff Classification of Renal Allograft Pathology

Roufosse, Candice; Simmonds, Naomi; Clahsen-van Groningen, Marian; Haas, Mark; Henriksen, Kammi J.; Horsfield, Catherine; Loupy, Alexandre; Mengel, Michael; Perkowska-Ptasińska, Agnieszka; Rabant, Marion; Racusen, Lorraine C.,; Solez, Kim; Becker, Jan U.
Transplantation: November 2018 - Volume 102 - Issue 11 - p 1795–1814
doi: 10.1097/TP.0000000000002366

The Banff Classification of Allograft Pathology is an international consensus classification for the reporting of biopsies from solid organ transplants. Since its initial conception in 1991 for renal transplants, it has undergone review every 2 years, with attendant updated publications. The rapid expansion of knowledge in the field has led to numerous revisions of the classification. The resultant dispersal of relevant content makes it difficult for novices and experienced pathologists to faithfully apply the classification in routine diagnostic work and in clinical trials. This review shall provide a complete and simple illustrated reference guide of the Banff Classification of Kidney Allograft Pathology based on all publications including the 2017 update. It is intended as a concise desktop reference for pathologists and clinicians, providing definitions, Banff Lesion Scores and Banff Diagnostic Categories. An online website reference guide hosted by the Banff Foundation for Allograft Pathology (www.banfffoundation.org) is being developed, which will be updated with future refinement of the Banff Classification from 2019 onward.

CLICK TO READ THIS OPEN ACCESS ARTICLE

In the News

Liver Transplantation for the GI Specialist: A 'Matter of Communication'

October 30 - Liver transplantation remains the last curable option for many chronic and severe acute liver diseases. For gastroenterologists who wish to play a more active role in liver transplant cases, the key to good pre- and posttransplant patient care is to communicate with the local transplant center and develop a proper team dynamic. Working together, the GI specialist and transplant center can minimize unnecessary transfers and improve follow-up.

READ THE FULL ARTICLE


Does the US discard too many transplantable kidneys?

October 27 - Comparing transplant data between countries may help address the global organ shortage, according to a study that will be presented at ASN Kidney Week 2018 October 23-October 28 at the San Diego Convention Center. The study provides evidence that some kidneys discarded in the United States are a lost opportunity that could have benefitted some patients.

READ THE FULL ARTICLE


UK - One in 10 people may opt-out of proposed organ donor system

October 29 - A new study has revealed that around one in 10 people are considering opting out of a proposed new system that aims to increase organ donation by presuming consent. The research, from the University of Stirling, found that those planning to opt-out of the new approach - earmarked for Scotland and England - reported stronger emotional barriers towards organ donation. These include discomfort at thinking about one's own death and feelings of disgust about organ donation.

READ THE FULL ARTICLE


Frailty may lower kidney failure patients' likelihood of receiving a transplant

October 27, 2018 - Frailty is associated with lower likelihoods of being placed on the kidney transplant waitlist and of receiving a transplant, according to a study that will be presented at ASN Kidney Week 2018 October 23-October 28 at the San Diego Convention Center.

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Time to Question Obesity-Based Cutoffs in Kidney Transplantation? Study finds outcomes non-inferior to patients with BMI 35 and under

October 29 - It's common for kidney transplant centers to reject potential recipients because they are highly obese, but critics in recent years have called these standards too strict. Now, a new study of transplant outcomes suggests that these restrictions are "arbitrary and unfounded," because these patients can actually fare well compared with their non-obese counterparts.

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Germany proposes law to increase organ transplants

November 1 - Just under 800 people donated their organs in 2016. Health Minister Jens Spahn wants to improve those numbers by revamping hospitals and introducing a system where you opt out of donating organs, rather than opting in.

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Heart - 'Increased-Risk' Transplant Safer Than Waiting

October 30 - Dennis Blough had been on the waiting list for more than 2 years when the call came. His surgeon at the University of Southern California in Los Angeles had a heart ready for transplant. But the good news came with a caveat: The heart was from an ''increased-risk'' donor.

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Thousands die waiting for liver transplants. This tactic could yield more organs.

October 31 - Each year in the United States, more than 2,500 people die while waiting to receive liver transplants or become too sick to undergo the surgery and must be removed from the wait list. As with hearts, kidneys, and lungs, there simply are not enough livers to go around. To increase the supply, researchers are pursuing a variety of strategies to rejuvenate "marginal" organs — those discarded because they are decayed, diseased in some way, or simply too old.

READ THE FULL ARTICLE

Upcoming Meetings

IPTA 2018 Symposium

ipta

The International Pediatric Transplant Association is proud to feature a special section activity: the 2018 Symposium in Organ Transplantation in Children: An educational forum for physicians, surgeons, and allied health professionals.

The focus of this symposium is aimed at clinical and research fellows in pediatric solid organ transplantation, as well as residents, and other allied health professional or non-physician trainees who are planning a career in pediatric transplantation.

VISIT THE SYMPOSIUM WEBSITE

IPTA 2019 - Call for Abstracts Now Open

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THE ORGANIZERS OF THE 10TH CONGRESS OF THE INTERNATIONAL PEDIATRIC TRANSPLANT ASSOCIATION WELCOME YOU TO SUBMIT AN ABSTRACT. THE SUBMISSION DEADLINE IS NOVEMBER 5, 2018.

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Subscribe to Tribune PulseView PAST ISSUES

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Webinar Announcement

6th

TRIAGE FOR SIMULTANEOUS LIVER KIDNEY TRANSPLANTATION AND CLINICAL PEARLS TO OPTIMIZE RENAL PROTECTION AFTER LIVER TRANSPLANTATION

NOVEMBER 6, 2018 - 2 PM EST (MONTREAL TIME)

Click here for full details and to signup

  Organizer: Sukru Emre, MD
Professor of Surgery (Transplant) and of Pediatrics, Yale University
New Haven, CT, USA
   Moderator: Marcelo Cantarovich, MD
Professor, Department of Medicine, Division of Nephrology, Faculty of Medicine, McGill University
Montréal, QC, Canada
  Discussant: Annmarie Huysman Liapakis, MD
Assistant Professor of Medicine (Digestive Diseases), Yale School of Medicine
New Haven, CT, USA
   Discussant: Clifford D. Miles, MD, MS, FAST
Associate Professor of Internal Medicine
University of Nebraska Medical Center
Omaha, NE, USA

TRANSPLANTATION DIRECT JOURNAL - HIGHLIGHTED ARTICLE

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Dr Andrea Schlegel, Editorial Fellow, Transplantation.

Heavy Alcohol Use Among Decesased Donors Does Not Impact Recipient Outcomes After Liver Transplantation
Aurora SS, Chahal KS, Axley P, et al.
Transplantation. Published online April 19, 2018. DOI:10.1097/TP.0000000000002230.

With a lack of guidelines supporting decisions on the use of livers from donors with a history of alcohol intake, there are significant regional variations in organ discard rates among centers and some surgeons remain reluctant to consider such livers for transplantation.
Arora and others explored the impact of heavy donor alcohol consumption on outcomes after liver transplantation. Based on the UNOS database, 47 882 liver transplantations were included in this retrospective analysis. The authors perform propensity score matching (PMS) and compared 21 498 livers from "nonheavy drinkers" with 7166 grafts donated from "heavy drinkers" (defined as more than 2 drinks/dd.). Endpoints were graft and patient survival.

The authors found, that donor alcohol history alone had no impact on outcome after liver transplantation. Although further analyses may be required to define certain risk combinations, this report appears important to initiate a careful assessment and procurement processes in donors, despite positive alcohol history.

In conclusion, history of "heavy drinking" alone in deceased donors does not appear to impact on graft and patient survival after liver transplantation. Prospective studies will help to identify parameters predicting outcomes and to increase a safe utilization of livers from donors with a history of alcohol intake.

CLICK TO READ THIS OPEN ACCESS ARTICLE

TTS-ILTS PAIRED TRANSPLANT CENTERS PROGRAM
Deadline January 1, 2019

tts ilts logo v2 70464486

The deadline to submit an application is JANUARY 1, 2019

The TTS-ILTS Paired Transplant Centers Program is a collaboration between The Transplantation Society (TTS) and the International Liver Transplantation Society (ILTS) supporting new liver transplant programs in emerging countries.

Visit www.tts-ilts.org for full detail

In the News

HIV Cure? HIV 'Eliminated' From Six Patients Using Stem Cell Transplants

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A recent study may have taken a big step towards finding an HIV cure. (Image via Pixabay)

October 19 - Finding an HIV cure has always proven difficult because of a viral reservoir of HIV cells that is untreatable by antiretroviral drugs, but Spanish doctors may have discovered a solution. Doctors believe six people afflicted with HIV have had the virus eliminated from their body and one may even have been completely cured of the virus, according to a study published in the journal Annals of Internal Medicine. The study was carried out by scientists from the Institue of AIDS Research IrsiCaixa in Barcelona and the Gregorio Marañón Hospital in Madrid, Spain, and gives new hope to developing a reliable HIV cure.

CLICK HERE TO READ MORE

High-Dose Influenza Vaccination May Benefit Transplant Recipient

October 17 - Double-dose influenza vaccine is safe and may increase antibody response in solid-organ transplant recipients, according to a study published in Vaccine.

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Functional Status In Candidates For Lung Transplantation: Why It Matters

October 17 - Transplantation is in some regards the "end of the line" therapy in medical care as transplantation specialists step in to replace entire organs after other interventions to preserve or restore function have failed. In lung transplantation, donor organs give patients with end-stage lung disease the capacity to breathe better, increase levels of physical activity and reclaim their independence. When successful, lung transplantation is life-changing in more ways than one can imagine.

READ THE FULL ARTICLE


Scientists grow functioning human neural networks in 3D from stem cells

October 18 - A team of researchers has developed three-dimensional (3D) human tissue culture models for the central nervous system that mimic structural and functional features of the brain and demonstrate neural activity sustained over a period of many months. With the ability to populate a 3D matrix of silk protein and collagen with cells from patients with Alzheimer's disease, Parkinson's disease, and other conditions, the tissue models allow for the exploration of cell interactions, disease and response to treatment.

READ THE FULL ARTICLE

How this researcher's risky idea could mean big things for regenerative medicine

October 22 - Every cell in your body contains thousands of different proteins. These complicated molecules regulate chemical reactions, bind to invading bacteria or viruses, carry signals in and between cells, and much more. They are vital to your existence. But determining which proteins are in a particular cell is difficult. The best processes scientists have developed can identify less than 100 of them. Now Nikolai Slavov, a researcher at Northeastern, has devised a method to identify more than a thousand proteins in an individual cell and estimate their abundance.

READ THE FULL ARTICLE


Engineering transplantable fat tissue

October 17 - Researchers at Boston University are the first to have succeeded in engineering vascularized fat tissue that grows or shrinks when given the appropriate physiological signal. The new work is an important step towards making large, centimetre-sized samples of adipose tissue for regenerative medicine applications.

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Organ donor shortage in Luxembourg

October 17 - Anyone in need of an organ donor in Luxembourg is in for a long wait as the grand duchy has among the lowest donor rates of any Eurotransplant member.

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Method for determining donor kidneys' suitability for transplantation may be flawed

October 25 - New research indicates that many kidneys obtained for transplantation from deceased donors are not being used because of biopsy findings despite their unreliability and reproducibility. The findings, which appear in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN) and will be published at ASN Kidney Week 2018, may suggest an urgent need to re-examine the role of such biopsies in the allocation of kidneys.

READ THE FULL ARTICLE


Study reveals racial and ethnic disparities in pediatric kidney transplantation outcomes

October 25, 2018 - Although there have been considerable reductions in disparities in adult kidney transplant outcomes in the United States, a new study found that disparities in long-term patient survival among pediatric kidney transplant recipients have worsened. The findings will be presented at ASN Kidney Week 2018 October 23-October 28 at the San Diego Convention Center.

READ THE FULL ARTICLE

Upcoming Meetings

IPTA 2018 Symposium

ipta

The International Pediatric Transplant Association is proud to feature a special section activity: the 2018 Symposium in Organ Transplantation in Children: An educational forum for physicians, surgeons, and allied health professionals.

The focus of this symposium is aimed at clinical and research fellows in pediatric solid organ transplantation, as well as residents, and other allied health professional or non-physician trainees who are planning a career in pediatric transplantation.

VISIT THE SYMPOSIUM WEBSITE

IPTA 2019 - Call for Abstracts Now Open

home page3

THE ORGANIZERS OF THE 10TH CONGRESS OF THE INTERNATIONAL PEDIATRIC TRANSPLANT ASSOCIATION WELCOME YOU TO SUBMIT AN ABSTRACT. THE SUBMISSION DEADLINE IS NOVEMBER 5, 2018.

call for abstracts large

Official Sections of The Transplantation Society

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