The Transplantation Society is a non-profit NGO providing global leadership in transplantation. Our core mission include the development of the science and clinical practice, scientific communication, continuing education and guidance on the ethical practice.

Subscribe to Tribune PulseView PAST ISSUES

header1b 2018 10

Transplantation DIRECT Journal OCtober Issue

txd2018 10


The October issue of Transplantation Direct delivers a variety of articles to peak your interest. In kidney transplantation, a number of issues related to organ suitability are investigated, including analyses of donor/recipient size matching, and the influence of donor age in cases of donation after circulatory death. A literature-based review of living kidney donor evaluation efficiency reveals promising opportunities to improve this process. Adherence to long-term immunosuppression and its relationship to kidney transplant histology are explored in detail. Predictive renal function tests for increased risk of cardiovascular events in kidney transplant recipients are investigated, and another article focuses on a predictive model for detecting hyperglycemia in nondiabetic recipients after liver transplantation. A first report on using hypothermic oxygenated machine perfusion to improve the quality of human pancreas grafts is also featured in this issue. In addition, we include publication of the 2018 islet and pancreas transplant report from the Australian and New Zealand group. Enjoy these and other aspects of the October Transplantation Direct issue!.

LINK TO THE ISSUE (OPEN ACCESS)

ISN-TTS SISTER TRANSPLANT CENTERS PROGRAM - Deadline Extended to tomorrow October 5

txd

The EXTENDED deadline to submit an application to the ISN - TTS Sister Transplant Centers Program is October 5, 2018 (for 2019).

The ISN-TTS Sister Transplant Centers Program is a joint partnership set up between ISN and The Transplantation Society (TTS) to create new kidney transplant centers and develop existing kidney transplant programs in emerging countries. This initiative encourages transplant centers to work together to increase opportunities for kidney transplant patients in developing countries.

Read more on th program and get some useful tips

Over 500 Signups TO DATE!
Registration Closes TuesdAY OCTober 9 at 23:59

TTS-STALyC ONLINE INTERACTIVE UPDATE COURSE
IMMUNOLOGICAL ASPECTS IN SOLID ORGAN TRANSPLANTATION

stalyc

From October 3 to November 27

Over an eight week period, featuring 28 online presentations, we will guide your through all the important aspects in immunology. We have enlisted many expert tutors to accompany the participants in the discussion by replying to questions throughout the week. The course was designed to allow participants to learn at their own pace and time during each week of the course.

The course has two sets of pricing (regular and for students/residents):

  • Regular fees are $100 USD, $40 USD for TTS or STALyC Members; $20 if you are a member of both TTS and STALyC.
  • Students/Residents can register for $40, $20 for TTS or STALyC Members, free for TTS AND STALyC Members.
  • We will allow registration at the reduced member fees if you submit your application(s) prior to registering for the course.

Share this information with your fellows, post-docs and students!

FOR MORE INFORMATION, PLEASE VISIT WWW.TTS-STALYC.ORG

TRANSPLANTATION JOURNAL - HIGHLIGHTED ARTICLE

txj

Dr Karen Keung, Editorial Fellow, Transplantation.

Long-term Outcomes of Pediatric En-Bloc Compared to Living Donor Kidney Transplantation: A Single-Center Experience With 25 Years Follow-Up.
Sureshkumar KK, Habbach A, Tang A, Chopra B.
Transplantation. 2018;102:e245-e248.

Pediatric en-bloc kidneys are not accepted by all centers for the transplantation into adults. There is limited data on extended long-term outcomes of these allografts. In a previous study, the authors had retrospectively compared the outcomes of pediatric en-bloc versus living donor kidney transplantation into adults at their center and identified inferior 1 year graft survival, but comparable 5-year graft survival and improved function up to 8 years following transplantation in en-bloc kidney recipients. In this retrospective review, the authors report on long-term outcomes of this cohort.
72 pediatric en-bloc and 75 living donor kidney transplants were transplanted between 1990 and 2001; immunosuppression was similar in both groups and included cyclosporine, azathioprine and prednisone prior to 1996 and cyclosporine, mycophenolate mofetil and prednisone for transplants between 1996 and 2001. Pediatric donors were 16.9 ± 11.2 months old and weighed 10.7 ± 3.8 kg with terminal serum creatinine of 0.50 ± 0.45 mg/dL. Living donors were 40.1 ± 9.4 years old and serum creatinine was 0.90 ± 0.16 mg/dL at the time of donation. Delayed graft function was more frequent in pediatric en-bloc kidneys (26.4% vs 6.7%, P = 0.001). Kaplan-Meier estimate revealed similar graft survival between the groups up to 27 years of follow up (log rank P = 0.78). Estimated glomerular filtration rates were consistently higher in pediatric en bloc kidney recipients from years 5 through 17 posttransplantation.
The study demonstrated that pediatric en-bloc kidneys confer long-term graft survival rates comparable to living donor kidneys and along with superior graft function, supporting the utilization of these allografts which may help alleviate the waiting list burden.

CLICK TO READ THIS OPEN ACCESS ARTICLE

Save tHe Dates!

dergi icin tts ist

Young Members Committee

The Young Members Committee is seeking active TTS members from Asia-Pac, Middle East, Africa and Latin America who want to take an active role in representing their regions.

Email This email address is being protected from spambots. You need JavaScript enabled to view it. if you are interested!

A reporter wrote an article on the illicit trade in human organs. Now people from all over the world email me trying to sell their kidneys

webcommerce

October 1 - As a foreign correspondent, I was accustomed to seeking out people in difficult circumstances. Now they were seeking me out, showing up in my email at all hours — when I was writing another story, racing to catch a flight, having dinner with my wife at home in Mumbai or trying to rock one of our newborn twins to sleep — and becoming impossible to ignore..

CLICK HERE To read more

In the News

Chung-Ang University Hospital succeeds in 3D-printing chest transplant

Professor Park Byung-joon and his team at Chung-Ang University Hospital’s Department of Thoracic and Cardiovascular Surgery announced on Thursday the successful surgery results of transplanting a 3D-printed ribcage to a patient with sarcoma, a malignant tumor that invaded the thorax.

READ THE FULL ARTICLE


Chronic allograft injury common among pediatric liver transplant recipients

September 28 - A substantial proportion of pediatric liver transplant patients with normal liver tests have varying degrees of subclinical chronic allograft injury, according to new findings. For the study, Dr. Sandy Feng of University of California, San Francisco, and her colleagues used data collected for iWITH, an immunosuppression-withdrawal trial that included 157 stable long-term recipients of liver transplants from living or deceased donors (45% boys).

READ THE FULL ARTICLE


COPD in patients after heart transplantation is associated with a prolonged hospital stay, early posttransplant atrial fibrillation, and impaired posttransplant survival

September 27 - COPD is associated with reduced physical activity, an increased risk for pulmonary infections, and impaired survival in nontransplant patients. The aim of this study was to investigate the influence of COPD in patients after heart transplantation (HTX).

READ THE FULL ARTICLE


Kidney Transplant Success Improved by Swedish Biotech’s Drug

There is hope for many patients on the kidney transplant waiting list, as a Swedish biotech’s lead candidate drug could help reduce rejections in kidney transplant patients.

READ THE FULL ARTICLE


Clear up this stem-cell mess

September 26 - Confusion about mesenchymal stem cells is making it easier for people to sell unproven treatments, warn Douglas Sipp, Pamela G. Robey and Leigh Turner.

READ THE FULL ARTICLE


HIV positive mom's liver transplanted into HIV negative child

October 4 - Johannesburg- In what is believed to be the first in the world, researchers at Wits University have transplanted a liver from an HIV positive mother to her HIV negative child.

LINK TO THE ARTICLE


Would you rather die of liver failure or live with HIV?

October 4 - This was the ethical dilemma faced by doctors at Wits Donald Gordon Medical Centre to save a child's life.

LINK TO THE ARTICLE


Heart transplant outcome linked to gut bacteria, study finds

October 4 - Gut bacteria appears to play a key role in whether a body accepts a transplanted heart, according to a new study. The study found bacteria appears to play a key role in the whether a body accepts a transplanted heart. The overall survival rate in the United States of heart transplants is about 88 percent after one year and about 75 percent after five years

READ THE FULL ARTICLE

IPTA 2019 - Call for Abstracts Now Open

home page3

THE ORGANIZERS OF THE 10TH CONGRESS OF THE INTERNATIONAL PEDIATRIC TRANSPLANT ASSOCIATION WELCOME YOU TO SUBMIT AN ABSTRACT. THE SUBMISSION DEADLINE IS NOVEMBER 5, 2018.

call for abstracts large

CLICK HERE FOR MORE DETAILS


Upcoming Meetings

CTRMS SPECIAL WORKSHOP

ctrms

Full program is now available on THEIR website!

VISIT THE WORKSHOP WEBSITE

IPTA 2018 Symposium

ipta

The International Pediatric Transplant Association is proud to feature a special section activity: the 2018 Symposium in Organ Transplantation in Children: An educational forum for physicians, surgeons, and allied health professionals.

The focus of this symposium is aimed at clinical and research fellows in pediatric solid organ transplantation, as well as residents, and other allied health professional or non-physician trainees who are planning a career in pediatric transplantation.

VISIT THE SYMPOSIUM WEBSITE

Subscribe to Tribune PulseView PAST ISSUES

header1b 09 27

Transplantation Journal OCtober Issue

txjcover

How important are DCs in tolerance and do Tfr have a role in antibody responses? Your questions are answered in this issue. Packed with information on issues as far apart as the progression of mGFR in living kidney donors; outcomes of bone marrow transplants in aplastic anemia; and a novel method to predict recurrence of HCC after liver transplantation, there is plenty to keep you interested.

LINK TO THE ISSUE

Link for TTS Members to Access (requires login)

ISN-TTS SISTER TRANSPLANT CENTERS PROGRAM - October 1 Deadline

txd

The deadline to submit an application to the ISN - TTS Sister Transplant Centers Program is October 1, 2018 (for 2019).

The ISN-TTS Sister Transplant Centers Program is a joint partnership set up between ISN and The Transplantation Society (TTS) to create new kidney transplant centers and develop existing kidney transplant programs in emerging countries. This initiative encourages transplant centers to work together to increase opportunities for kidney transplant patients in developing countries.

Read more on th program and get some useful tips

ALmost 300 Signups - LAST CHANCE FOR YOU TO REGISTER!
TTS-STALyC ONLINE INTERACTIVE UPDATE COURSE
IMMUNOLOGICAL ASPECTS IN SOLID ORGAN TRANSPLANTATION

stalyc

From October 3 to November 27

Over an eight week period, featuring 28 online presentations, we will guide your through all the important aspects in immunology. We have enlisted many expert tutors to accompany the participants in the discussion by replying to questions throughout the week. The course was designed to allow participants to learn at their own pace and time during each week of the course.

The course has two sets of pricing (regular and for students/residents):

  • Regular fees are $100 USD, $40 USD for TTS or STALyC Members; $20 if you are a member of both TTS and STALyC.
  • Students/Residents can register for $40, $20 for TTS or STALyC Members, free for TTS AND STALyC Members.
  • We will allow registration at the reduced member fees if you submit your application(s) prior to registering for the course.

Share this information with your fellows, post-docs and students!

FOR MORE INFORMATION, PLEASE VISIT WWW.TTS-STALYC.ORG

TTS IS exhibiting at THE Transplant Nursing Symposium

ITNS18 Web banner1500x450

Come visit our booth!

CLICK HERE FOR MORE INFORMATION ABOUT THE SYMPOSIUM

Heart, Heart-Lung Specialists Wanted!

The Heart and Lung Committee is seeking TTS Heart and Lung Specialist who want to take an active role in increasing H+L activity at TTS.

Email This email address is being protected from spambots. You need JavaScript enabled to view it.  if you are interested!

WIT OCtober 4 Networking event @ ASHI

wit

Space is limited - signup today!

NIH's first Chief Officer for Scientific Workforce Diversity, Dr. Hannah Valantine, will describe NIH's current approach and activities related to promoting inclusive excellence through fostering workforce diversity, and highlight four main diversity challenges facing biomedicine. She will also describe the development and use of the NIH Scientific Workforce Diversity Toolkit: a free, downloadable interactive resource to help advance faculty diversity through evidence-based interrelated activities. A key focus will be the need to advance institutional accountability for lasting change.

Clikc here for more details and to signup

Save tHe Dates!

dergi icin tts ist

 

 

TRANSPLANTATION JOURNAL - HIGHLIGHTED ARTICLE

txj

Dr Karen Keung, Editorial Fellow, Transplantation.

Beta Cell Death by Cell-free DNA and Outcome After Clinical Islet Transplantation
Gala-Lopez BL, Neiman D, Kin T, et al.
Transplantation. 2018;102:978-985.

Successful islet transplantation (IT) may be hindered by cell death linked to cell hypoxia and inflammatory responses in the early stages after intraportal infusion. Clinically, more than 1 infusion is often required to achieve insulin independence. There are currently no established measures to determine extent of beta cells death, however circulating cell-free DNA (cf-DNA) derived from beta cells has been recently identified as a potential novel biomarker to detect cell loss in newly diagnosed Type 1 DM and islet graft recipients. In this study the authors measured levels of beta cell-specific cf-DNA in a clinical cohort and evaluated findings against outcomes including insulin independence by 3 mths posttransplant. Patients receiving a first intraportal allotransplant or a retransplant after a < 1 year were included. In total, 37 recipients had blood taken at 1 hour, 24 hours, 7 days, and 1 month after IT; cf-DNA was extracted from the plasma. 20 patients (54.1%) were insulin independent 3 mths posttransplant, and a favorable Beta 2 score (>15 points) was calculated. Two distinct signal peaks of beta cells cf-DNA levels were identified by 1 (83.8% of patients) and 24 hrs (21.6% of patients). The signal by 1 hr did not correlate with outcomes; however, the 24-hr positive beta cell cf-DNA level was inversely associated with both insulin independence (ROC AUC = 0.70, P = 0.03) and beta 2 score (ROC AUC= 0.77, P = 0.006). The authors submit that 24- hr beta cell cf-DNA levels may predict early engraftment by 3 mths and may complement the initial assessment of islet engraftment and function.

CLICK TO READ THIS OPEN ACCESS ARTICLE

Organ transplant documentary on Nova reveals hope as well as agony

wppic

In the documentary "Transplanting Hope," parents look at their baby. The infant is in need of a transplant. (National Film Board of Canada)

The documentary, which aired on PBS stations at 9 p.m. Wednesday, takes viewers into hallways, conference rooms, airplanes, research labs and operating theaters where the life-or-death drama of organ transplantation takes place. It looks toward future technologies that could make procedures more successful. And it makes the stakes of a worldwide organ shortage clear.

CLICK HERE To read more

In the News

Uterus transplantation -- ethically just as problematic as altruistic surrogacy

September 26 - In 2014, the first child to have been gestated in a donated uterus was born. Although research into uterus transplantation is still in an early phase, many see the donations as a success. Researchers have now studied ethical aspects of uterus transplantation. The results show that uterus transplantation with living donors is ethically just as problematic as altruistic surrogacy.

READ THE FULL ARTICLE


Disparities seen in access to preemptive transplant listing

September 27 - The new Kidney Allocation System has not solved inequities that low-income and minority patients with kidney disease face when seeking the benefits of preemptive waitlisting for a transplant, Drexel University College of Medicine researchers reported in a study published in the Journal Clinical Transplantation.

READ THE FULL ARTICLE


Hepatitis C triples diabetes risk following kidney transplantation

September 26 - Risk for developing diabetes after undergoing kidney transplantation increased more than threefold for adults with presurgical hepatitis C infection vs. those with hepatitis B and those without infection, according to study results from researchers in China.

READ THE FULL ARTICLE


Research provides new insight into transplant rejection

September 27 - In a new study, published in Nature Communications, researchers from Brigham and Women's Hospital reveal insights that may help explain the mechanisms behind skin graft failure. The results of the study may also help make organ transplantation more successful in the future.

READ THE FULL ARTICLE


3D Action Film Stars Cancer Cell as the Villain

A team has developed a new hybrid imaging technology to produce amazing, live-action 3D movies of living cells in their more natural state. In this video, you're looking at a human breast cancer cell (green) making its way through a blood vessel (purple) of a young zebrafish.

LINK TO THE ARTICLE


Managing Organ Donation Preferences in Cases With Circulatory Determination of Death

September 19 - Organ donation immediately following the withdrawal of life-sustaining therapy and circulatory determination of death (DCDD) is a growing practice, allowing transplantation surgical staff to rapidly recover organs prior to ischemic organ injury.

LINK TO THE ARTICLE


Kidney Transplant Outcomes Unaffected by Dialysis Modality

September 21 - Choice of dialysis modality—hemodialysis (HD) or peritoneal dialysis (PD)—prior to kidney transplantation does not affect transplant outcomes, according to a study. Following receipt of kidneys from donors after cardiac death, patients who previously had been on PD or HD had similar rates of complications and patient, graft, and death-censored graft survival, Xiajing Che, MD, of Shanghai Jiao Tong University in Shanghai, China, and colleagues reported in BMC Nephrology.

READ THE FULL ARTICLE

IPTA 2019  - Call for Abstracts Now Open

home page3

THE ORGANIZERS OF THE 10TH CONGRESS OF THE INTERNATIONAL PEDIATRIC TRANSPLANT ASSOCIATION WELCOME YOU TO SUBMIT AN ABSTRACT. THE SUBMISSION DEADLINE IS NOVEMBER 5, 2018.

call for abstracts large

CLICK HERE FOR MORE DETAILS


Upcoming Meetings

CTRMS SPECIAL WORKSHOP

ctrms

Full program is now available on THEIR website! 

VISIT THE WORKSHOP WEBSITE

IPTA 2018 Symposium

ipta

The International Pediatric Transplant Association is proud to feature a special section activity: the 2018 Symposium in Organ Transplantation in Children: An educational forum for physicians, surgeons, and allied health professionals.

The focus of this symposium is aimed at clinical and research fellows in pediatric solid organ transplantation, as well as residents, and other allied health professional or non-physician trainees who are planning a career in pediatric transplantation.

VISIT THE SYMPOSIUM WEBSITE

Official Sections of The Transplantation Society

ctsisodp new logo v7