The Transplantation Society is a non-profit NGO providing global leadership in transplantation. Our core mission include the development of the science and clinical practice, scientific communication, continuing education and guidance on the ethical practice.

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Transplantation Direct - May 2018 - Volume 4 - Issue 5

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This month in Transplantation Direct we feature a wide variety of topics in transplantation. For those interested in liver transplantation, performing transplants with a venovenous bypass is explored in a large single center Canadian study, and Duke surgeons present a case of complications associated with an accessory gallbladder. A Japanese group examines the safety of performing an adult living donor liver transplant in patients with portal vein thrombosis; other articles focus on the value of MRCP in diagnosing biliary anastomotic strictures, and on mechanisms involving endothelial cell dysfunction in the context of steatotic human livers. In heart transplantation, data supporting the feasibility of biomarker use for monitoring right heart pressures is introduced. For those interested in kidney transplantation, we have reports on modifiable factors associated with prolonged warm ischemia time, a modified Delphi Study in the UK related to optimizing listing for transplantation, and on the use of personalized patient evaluation protocols for making decisions on live donation. Lung transplant studies are also included in this issue, examining cyclophosphamide use for refractory acute cellular rejection, and an analysis of long-term outcomes in combined lung-liver transplants. We hope that you find this content useful and look forward to an article contribution from you soon.

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Sindh Institute Of Urology And Transplant's Biomedical Ethics Centre Joins WHO Regional Activities

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April 26 - The Centre of Biomedical Ethics and Culture (CBEC) of the Sindh Institute of Urology and Transplant (SIUT) was designated as a World Health Organisation (WHO) Collaborating Centre in Bioethics at a special ceremony held at the SIUT.

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Hospital first in UK to introduce pioneering liver transplant technology

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Professor Chris Watson and Andrew Butler with the new machine (Sally Wardle/PA).

May 2 - A hospital has become the first in the UK to bring state-of-the-art liver transplant technology into routine practice. Addenbrooke's Hospital in Cambridge will use machine perfusion, a process which can keep a liver "alive" outside the body for up to 24 hours by maintaining it at body temperature. The technology allows doctors to test how well a liver is functioning before transplant, boosting the chances the procedure will be a success. Addenbrooke's has become the only liver transplant centre in the UK to use the perfusion technique as part of its standard clinical practice.

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In the News

Transflammation: A New Frontier In Regenerative Medicine

May 1 - Cardiovascular regeneration focuses on repairing or replacing damaged or senescent cardiac and vascular tissue. This damage is largely caused by myocardial ischemia (poor perfusion of the heart causing dysfunction or loss of cardiac tissue), fibrosis (with the replacement of myocytes and vessels with non-functional scar tissue) each of which may lead to heart failure, impaired functional capacity and quality of life, serious arrhythmias, and death.

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Implantable islet cells come with their own oxygen supply

April 25 - Treating type-1 diabetes by transplanting islet cells becomes a trend but proven challenging. One impediment is that once the islets are transplanted, they will kick the bucket in the event that they don't get a sufficient supply of oxygen. Presently, scientists at MIT, working with an organization called Beta-O2 Technologies, have created and tried an implantable gadget that outfits islet cells with their own supply of oxygen, by means of a chamber that can be recharged like clockwork.

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Organ Donation System Set For Changes

April 28 - NPR's Scott Simon speaks to transplant surgeon Dr. Dorry Segev about why the current system of organ allocation can be a death sentence for some patients.

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THE HEART PRINTER

April 18 - THE IDEA:Bioprinting fully functioning human hearts to be used for transplants. Steven Morris, 53, started BioLife4D in 2016, bringing on board Jeffrey Morgan, the head of cardiothoracic transplantation at Baylor College of Medicine, as chief medical officer. Bioprinting a full-size human organ has never been done. But Morris and Morgan have devised a method they believe can work that involves extracting blood cells from a transplant candidate, reengineering them into heart cells, then 3D printing the heart cells layer by layer into a functioning organ—chambers, valves, and all.

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TTS 2018 - SPOTLIGHT ON MORNING SYMPOSIA

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Thirty Sessions over 4 days with Key Opinion leaders in the field!

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USA - Wounded veteran receives first penis and scrotum transplant

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Members of the medical team who performed the first successful penis and scrotum transplant at Johns Hopkins Hospital in Baltimore.

April 24 - (CNN) The world's first successful total penis and scrotum transplant was completed at Johns Hopkins Hospital on March 26, according to a news release issued Monday. The procedure lasted 14 hours and involved nine plastic surgeons, two urological surgeons and a team of anesthesiologists, nurses and surgical technicians, according to the release.

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Seven-year-old boy recovering well after first five-organ transplant

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Jay Crouch received two kidneys, a pancreas, liver and bowel during a single 10-hour operation.
Photograph: Birmingham Women and Children's NHS foundation trust

April 25 - A seven-year-old boy has become the first child to undergo a five-organ transplant in a single operation. Jay Crouch, who has a condition that left his small intestine twisted and has caused complications with other organs since he was six weeks old, is recovering at home after receiving two kidneys, a pancreas, liver and small bowel during the 10-hour operation at Birmingham children's hospital.

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Your opinion Counts!
What is the most important TTS membership benefit to you?

  • Supporting TTS vision
  • Access to global network of physicians, basic scientists, and allied health professionals involved in transplantation
  • Publications (journals, newsletters)
  • Committee involvement
  • Voting and nomination rights for the election of TTS Officers and Councillors
  • Professional development incl. webinars, multimedia library, travel awards
  • Reduced registration fees at our international congresses
  • Reduced journal rates
  • Reduced membership fee for emerging economy nations

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Transplantation DIRECT Journal - Featured Article

Submitted by Dr Peri Kocabayoglu Editorial Fellow, Transplantation.

A Formula to Calculate Standard Liver Volume Using Thoracoabdominal Circumference.

Shaw BI, Burdine LJ, Braun HJ, Ascher NL, Roberts JP.
Transplant Direct. 2017 ;3(12):e225.

Living donor liver transplantation (LDLT) as well as split liver grafts require precise calculations of the minimum graft volume to avoid complications. While current formulas are mostly based on weight-based parameters, they can often be inaccurate. Brian Shaw and co-workers from UCSF developed a new formula using the thoracoabdominal circumference (TAC) to predict liver volume for living donor liver transplantation (LDLT) donors. The proposed formula, SLV = (TAC × 3.5816) - (Age × 3.9844) - (Sex × 109.7386) - 934.5949, calculated standard liver volume (SLV), predicted SLV and identified patients with small grafts. This equation is a useful tool estimating not only the minimal required liver volume that living donor recipients need, the score also defining the ideal liver volume for a patient undergoing whole graft deceased donor liver transplant. Those data have the potential to pave the way for further refinements using a larger cohort, and to define a cut-off for liver transplant volume.

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A NEW WAY TO EASE THE ORGAN SHORTAGE: 'REGIFTING' KIDNEYS USED IN PREVIOUS TRANSPLANTS

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Dr. Jeffrey Veale (right) performs a kidney transplant at Ronald Reagan UCLA Medical Center.

April 24 - UCLA - Like many transplant surgeons, Dr. Jeffrey Veale got frustrated seeing so many of his patients die while waiting for a donor kidney. So he decided to do something about it: recycle. Since last year, the UCLA surgeon has transplanted three "regifted" kidneys from previous transplant recipients who died with their donated kidneys still healthy — breaking an unspoken taboo against using kidneys for a third time. Veale said some 25 percent of people who receive kidney transplants die with organs that are perfectly acceptable for transplant into another recipient, and he is pushing hard for other transplant centers around the nation to do the same to help ease the crushing shortage of donor kidneys.

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In the News

  • SINDH CONFERENCE AT SIUT MULLS WAYS TO PROMOTE ORGAN DONATION AFTER DEATH
  • TRANSPLANTED LIVERS HELP BODY DEFEND AGAINST ORGAN REJECTION, MAYO CLINIC STUDY FINDS
  • 'PATIENCE, FAITH AND HOPE': FAMED SINGER 'EL PUMA' DISCUSSES DOUBLE LUNG TRANSPLANT IN MIAMI
  • DALLAS SURGEON MAKES TIME 100 LIST OF MOST INFLUENTIAL PEOPLE FOR BAYLOR UTERUS TRANSPLANT SUCCESS
  • NEW CELL THERAPY AIDS HEART RECOVERY—WITHOUT IMPLANTING CELLS
  • SCIENTISTS GENERATE AN ATLAS OF THE HUMAN GENOME USING STEM CELLS
  • TEST SHOWS SIGNIFICANCE OF SCREENING FOR GENOMIC VARIANTS THAT COULD IMPACT TREATMENT
  • EXTRAHEPATIC EFFECTS OF HCV ERADICATION WITH DAAS IN LIVER TRANSPLANT RECIPIENTS
  • USA - FOR THE FIRST TIME IN YEARS, NEW GROUPS MAY VIE TO RUN ORGAN TRANSPLANT NETWORK

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