The Transplantation Society is a non-profit NGO providing global leadership in transplantation. Our core mission include the development of the science and clinical practice, scientific communication, continuing education and guidance on the ethical practice.

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transplantation Journal - September 2018 Issue

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In this issue we have something for every organ transplant—motherhood after heart transplantation, chronic lung rejection, the problem of coagulation in cirrhosis, new issues in islet transplantation and a very useful guide to meta-analysis.

Link to the issue

Link for TTS Members to Access (requires login)

transplantation Journal - Highlighted Article

Submitted by Dr Joel Thomas Adler, Editorial Fellow, Transplantation.

Effects of Kidney Transplantation on Labor Market Outcomes in Sweden.
Jarl J, Gerdtham U-G, Desatnik P, Prütz K-G.
Transplantation
. 2018;102:1375-1381.

While accepted as a cost-efficient intervention, there is little known about kidney transplantation and its wider effects, such as labor market outcomes. Utilizing national data from Sweden and controlling for treatment selection bias, Jarl and colleagues demonstrate that transplant recipients are 21 percentage points more likely to be working than those on dialysis. Five-year results suggest that effects are even more pronounced over time, mainly due to continued decline of health while on dialysis. Understanding the downstream effects of kidney transplantation will help to quantify the true value of increasing the supply of donated kidneys.

Link to the article

transplantation Journal - September 2018 Issue

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Here's the latest #PresentYourPaper video by Dr. Bettina Buchholz and colleagues:

CLICK HERE TO WATCH THE VIDEO

CLICK HERE TO READ THEIR PAPER

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About #PresentYouPaper

We encourage young authors (<40 years old) to present papers that have been accepted for publication in Transplantation during a 30-second video. Once the videos have been reviewed and edited as needed, we will tweet your presentation out to our Twitter followers. Please note that authors must create and film the video presentations themselves using a smartphone or camera. We are looking forward to receiving the first #PresentYourPaper submissions!

For more information, email This email address is being protected from spambots. You need JavaScript enabled to view it. .

Will Egyptians change their minds about organ donation?

August 21 - Top Egyptian health officials recently triggered a public row following their remarks that give the green light for the removal of deceased persons' corneas without their families' consent. This issue has rekindled a years-old broader debate over organ donation in Egypt.

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Upcoming Meetings

MESOT 2018 - Less THan 2 weeks away!

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TTS will be exhibiting at MESOT and a large number of TTS members will be attending or presenting at the Congress. There is still time to register, see link below!

Visit the MESOT 2018 Website


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Continuing our strong partnership with the International Liver Transplantation Society (ILTS), The Liver Transplant Symposium 2018, organised by the National University Centre for Organ Transplantation (NUCOT), will be held from 19 – 21 October 2018 in Singapore.

Visit the symposium website



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The International Pediatric Transplant Association is proud to feature a special section activity: the 2018 Symposium in Organ Transplantation in Children: An educational forum for physicians, surgeons, and allied health professionals.

The focus of this symposium is aimed at clinical and research fellows in pediatric solid organ transplantation, as well as residents, and other allied health professional or non-physician trainees who are planning a career in pediatric transplantation.

VISIT THE SYMPOSIUM WEBSITE


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On behalf of The Transplantation Society of Taiwan, we would like to extend our warmest invitation to you to join Transplantation Sciences Symposium (TSS) Asian Regional Meeting 2018, which is scheduled to take place at Taipei Marriott Hotel, Taipei, Taiwan from November 23rd to 25th, 2018.

The meeting includes Plenary Lectures (two from TTS Members) Shane Grey and Stefan Tullius, Satellite Symposia, Parallel Presentations and Exhibits. Experts from different domains will be invited to share their expertise and experience in transplantation field. This will be a fabulous chance to exchange the ideas, contribute the most newly developed knowledge, one-of-a-kind cultural and educational experience.

VISIT THE SYMPOSIUM WEBSITE


In the News

Program helps kidney transplant recipients avoid common weight gain, shows additional potential

August 20 - University of Kansas researchers have tested a program that helps kidney transplant recipients improve their diet, increase physical activity and prevent weight gain, all without leaving their home.

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Study reports successful kidney transplants from donors with a history of hepatitis C

Researchers at Loma Linda University Health found that kidney transplantation can be safely performed using organs testing positive for the hepatitis C virus (HCV) antibody but negative for active viral infection.

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Is There an "Ideal" Cystic Fibrosis Candidate for Lung Transplantation?

As diagnostics become more sophisticated, more adults are being diagnosed with cystic fibrosis (CF). Although patients with CF tend to have shorter expected life expectancies than the general population, researchers are exploring methods that predict outcomes, even in patients who are diagnosed well into adulthood.

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How OSU Wexner physicians 'test drive' damaged organs before transplants

August 13 - Columbus-based Ohio State University Wexner Medical Center created a lung perfusion program in August 2016. In the past two years, physicians used perfused lungs for 11 out of 92 transplants.

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Advancement of organ regeneration for transplantation

Last week an article appeared in Wired magazine about a recently paper published in Science Translational Medicine, “Production and transplantation of bioengineered lung into a large-animal model”. The Transplantation Society asked one of our own experts, Christopher Burlak from the University of Minnesota, to provide our readership with a commentary regarding the advancement of organ regeneration for transplantation.

Commentary on the advance of organ regeneration for transplantation.

BurlakChristopher Burlak, Associate Professor of Surgery and Scientific Program Director of the Schulze Diabetes Institute at the University of Minnesota.

One of the most challenging organs to transplant is the lung.  Because of a complex mucosal network riddled with immune cells, transplanted lungs are very sensitive to rejection during allo- or xeno-transplantation.  If one could, however, grow a lung from cells of the future recipient, perhaps immune mediated rejection would not be an issue.  The challenges of growing bioengineered organs are not trivial, as described by Dr. Joan Nichols and her colleagues in the recently published article in Science Translational Medicine titled, “Production and transplantation of bioengineered lung into a large-animal model”[1].  Mr. Robbie Gonzalez has written a commentary[2] for the magazine Wired that highlights their scientific achievement.  I was inspired by Mr. Gonzalez’s commentary and reached out to Dr. Nichols to discuss the science, the challenges, and what comes next. 

Continue reading the commentary ...

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Many of these important topics will be discussed at IXA 2019. Make sure to mark your calendar!

Read more about the IXA 2019 Congress

October 2018 Liver Transplant Symposium

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Continuing our strong partnership with the International Liver Transplantation Society (ILTS), The Liver Transplant Symposium 2018, organised by the National University Centre for Organ Transplantation (NUCOT), will be held from 19 – 21 October 2018 in Singapore.

This symposium aims to advance knowledge and expertise in liver transplantation, through multi-disciplinary collaborations within the transplant community to improve the outcomes of our patients.

A key segment of The Liver Transplant Symposium 2018 is undoubtedly the inaugural Living Donor Summit, which will be the first of its kind in Asia. Organised in partnership with the ILTS and The Transplantation Society (TTS), world-renowned key opinion leaders will be invited to discuss state of the art topics, focussing on ethical considerations and best practices in living donor liver transplantation in South East Asia.

The first day of the symposium will also feature a Liver Transplant Surgical Workshop, Simulation in Anaesthesia for Liver Transplantation (SALT) Workshop and Transplant Hepatology Workshop, which have all been very well received in past years by both senior clinicians and trainees.

We look forward to welcoming you to The Liver Transplant Symposium 2018 in Singapore.

Visit the symposium website

Interesting CNN article on face transplantation

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Katie Stubblefield tried to kill herself with a gun at 18; now, she is the youngest face transplant recipient in US history.

She is featured on the cover of National Geographic magazine's September issue, which debuted Tuesday, in an article titled "The Story of a Face" and in National Geographic's full-length documentary "Katie's Face."

Read the full article

Highlighted Article - Transplantation Direct

Dr Peri Kocabayoglu, Editorial Fellow, Transplantation.

Liver Enzymes and the Development of Posttransplantation Diabetes Mellitus in Renal Transplant Recipients.
Klaassen G, Corpeleijn E, Deetman NPE, et al.
Transplant Direct.
2017;3:e208.

Posttransplantation diabetes mellitus (PTDM) increases the risk of graft failure, infections, cardiovascular disease, and early mortality. Risk factors including immunosuppression, cytomegalovirus (CMV) infections, waist cirucumference, hyperlipidemia, and hypertension have been identified. Impaired function and steatosis of the liver are observed as part of the metabolic syndrome.
In this prospective cohort study, Klaassen and coworkers tested the link between liver enzymes and PTDM in 500 kidney transplant recipients. Patients with diabetes at the time of transplantation were excluded.

During a follow up of 9.6 years, 15.2% of renal transplant recipients developed PTDM. The authors found that levels of alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) were significantly (and independently) associated with PTDM. Moreover, elevated liver enzymes were associated with increased BMI and waist circumference, supporting the concept that abdominal and hepatic fat accumulation are closely linked. The administration of Tacrolimus did not seem to impact the predictive capacity of elevated liver enzymes for the development of PTDM.
Limitations of this study include a lack of abdominal imaging or liver biopsies as objective parameters of steatosis and adipositas. Moreover, insulin resistance has also not been tested.  Nevertheless, this study may have clinical implications linking elevated liver enzymes as markers of an impaired hepatic glucose metabolism with PTDM.

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Highlighted Tweet by Transplantation Direct

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Scientists identify why some kidney transplants don't work

August 13 - Scientists have discovered a 'molecular signature' for the allostatic load – or 'wear and tear' of kidneys – which could help clinicians understand why some kidney transplants don't work as well as expected. The University of Glasgow-led research, published today in Aging Cell and based on a first-of-its-kind study, can now explain why allostatic load develops at a molecular and cellular level, how it affects physiological function and the role of age-related organ capability and resilience.

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Spain and Italy perform the first international paired kidney exchange in Southern Europe

August 9 - One patient in Spain and another in Italy were able to receive a living donor kidney transplant thanks to the exchange of organs from their respective donors.
CLICK HERE TO READ THIS ARTICLE

MESOT 2018 - Less THan 3 weeks away!

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TTS will be exhibiting at MESOT and a large number of TTS members will be attending or presenting at the Congress. There is still time to register, see link below!

Visit the MESOT 2018 Website


In the News

New Medications May Increase Available Organs for Transplant

August 9 - Until recently, organs from donors who died of drug overdoses were often discarded due to concerns about hepatitis C.

READ THE FULL ARTICLE


Turning cells into factories

August 10 - Researchers in the University of Georgia College of Engineering have developed a new genetic “smart circuit” that could signal an important advance in the field of metabolic engineering. They outline their findings in a study published this month in the journal Nature Communications.

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3D-printed nerve stem cells could help patch up spinal cord injuries

August 10 - Spinal injuries can be like downed power lines – even if everything on either side of the injury is perfectly functional, the break can effectively shut down the whole system. Now, researchers at the University of Minnesota have designed a device that could link everything back together again. A silicone guide, covered in 3D-printed neuronal stem cells, can be implanted into the injury site, where it grows new connections between remaining nerves to let patients regain some motor control.m.

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Program testing EHR role in speeding organ donation process

August 13 - The United Network for Organ Sharing is working with software vendors Cerner and Statline to automate manual processes surrounding organ donations. The initiative aims to improve the process for notifying hospitals about potential organ donors, with the hopes of reducing the time it takes to get an organ to needy patients.

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Official Sections of The Transplantation Society

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