The Transplantation Society is a non-profit NGO providing global leadership in transplantation. Our core mission include the development of the science and clinical practice, scientific communication, continuing education and guidance on the ethical practice.

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TTS 2018 - A resounding success

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A big thank you to all attendees and supporters of the congress.  TTS 2018  featured 3000+ partcipants from 99 countries and We will be featuring highlights from the congress in upcoming issues of the Tribune pulse. The presentation recordings will be available as of July 26, 2018 for TTS members and COngress attendees.

Congratulations to our 2018 Medawar Laureates

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Congratulations to both Kathryn Wood and Megan Sykes on being awarded the 2018 Medawar Prize.

The Medawar Prize is widely recognized as the most prestigious award in the field of transplantation. This year's award was supported by Baskent University.

For a limited time you can watch the entire President's Plenary - Click here to signup

Transplantation DIRECT - Just Released!

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This month Transplantation Direct offers new findings on a variety of topics. In kidney transplantation, a new pharmacodynamics assay meant to adjust tacrolimus levels is tested involving an NFAT-dependent cytokine assay. Two studies involve pediatric kidney transplantation; an interesting analysis of the impact of HLA mismatching is presented, and a European survey on the management of transition from pediatric to adult care is evaluated – including adherence to 2011 ISN/IPNA guidelines. For liver, a valuable base of information is provided regarding the use of different immunosuppressive regimens in the US, and cardiac MRI T2* in liver transplant candidates is evaluated as a supplemental diagnostic tool for predicting posttransplant cardiac complications. In the area of VCA, the frequency of kidney dysfunction related to immunosuppression is evaluated. The issue also contains 2 articles related to organ donation and procurement; a study from Norway presents a protocol for controlled DCD using normothermic regional perfusion, and a Canadian group explores via survey, frontline intensive care unit professionals' and organ donor coordinators' perceptions and beliefs related to key factors in the process of donation after circulatory determination death. In the basic sciences, a study is presented on the potential for the small molecule tyrosine kinase inhibitor Nintedanib to reduce allograft vasculopathy in a murine aortic graft model. We hope that this issue touches some aspect of your interests in the field of transplantation.

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‘Justina's Law’ Set to Make Everyone in Argentina an Organ Donor

July 5 - Spurred into action by the death of a 12-year-old girl awaiting a heart transplant, Argentina is about to make everyone an organ donor. The lower house of Congress unanimously passed a bill late Wednesday that makes all citizens in the nation of 44 million donors unless they explicitly express otherwise. Only 287 citizens had elected to donate their organs this year, according to government statistics.

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JUly 12 - 8am Montreal time (2 pm CEST Time)
Webinar - ISN-TTS Sister Transplant WebinAR Providing TIPS to make  your application SHINE 

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Watch our webinar to get some tips

Sister Centers Programs link renal and transplant centers in low-and-middle income countries with centers of excellence in the developed world. There are now 65 active Sister Centers partnership and 13 of them are focused on transplantation.

The deadline to apply for the ISN Sister Renal Centers Program and the ISN-TTS Sister Transplant Centers Program is set for October 1st, 2018.

Learn to make your application stand out and register for a special webinar to be broadcast on July 12, 2018 between 2PM and 3PM CEST.

Peter Kerr, Chair of the Sister Renal Centers Program, and Philip J. O'Connell, Past-President of The Transplantation Society and Director of Transplantation, will guide you through each step of the application process. They will share some handy tips on how to prepare a successful application and answer any questions you may have.

CLICK HERE TO SIGNUP

Transplantation - Featured Article

Submitted by Dr Peri Kocabayoglu, Editorial Fellow, Transplantation.

Differences in Proinflammatory Cytokines and Monocyte Subtypes in Older as Compared With Younger Kidney Transplant Recipients
Liang EC, Rossetti M, Sidwell T, et al.
Transplant Direct. 2018;4:e348.

The proportion of elderly patients with End Stage Renal Disease has increased dramatically over the last 2 decades. Moreover, elderly kidney transplant recipients do not only have higher rates, but also an increased risk of death due to infection. On the other hand, older transplant recipients are less likely of experiencing acute rejections. However, if developing rejections, elderly transplant recipients are less likely to respond favorably to treatment. Overall, immune dysfunctions are critically important in these elderly kidney transplant recipients. Among other immune deficiencies, decreased NK cell cytokine production and cytotoxicity, in addition to impaired phagocytosis and reactive oxygen species production by monocytes/macrophages have been noted. Other aspects of age-related immune dysfunctions include decreased TLR4 expression on Dendritic and other innate immune cells.
Here, Liang and coworkers address aspects of age-associated differences in plasma cytokine levels and monocyte subtypes of 60 kidney transplant recipients. By 3 months after transplantation, innate immune phenotypes were evaluated in 22 patients ≥ 60 years, and 38 patients < 60 years. Older patients displayed significantly decreased frequencies of intermediate monocytes (CD14++CD16+) (1.2% vs. 3.3%, p=0.007), and increased levels of proinflammatory classical monocytes (CD14++CD16-). Moreover, levels of IFN-γ were increased in recipients older than 60 years.
Age-dependent differences in monocyte subtypes may represent a mechanism explaining the compromised response to infections in the elderly. Moreover, augmented levels of proinflammatory cytokines may explain the persistence of nonspecific inflammation in the presence of immunosuppression.
Results of this pilot study will need to be confirmed in larger cohorts to fully address the scope of inflammatory cytokine changes and monocyte subtype levels and their impact on transplant outcome in elderly transplant recipients.

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In the News

Strained Guts: Engineering Human Intestinal Organoids for Transplantation

June 26 - The increasing demand for organ transplantation has led many researchers to look for innovative ways to replace the need for human donors. Research in organoids, which are stem cell derived miniature mimics of organs typically grown in a dish, has significantly improved our understanding of organ development and structural organization.

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New method for turning skin cells into pluripotent stem cells

July 6 - Researchers have for the first time succeeded in converting human skin cells into pluripotent stem cells by activating the cell's own genes.

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Virtual Reality Isn't Just For Gamers Anymore; It Will Change Your Health

July 10 - As virtual reality (VR) software becomes more sophisticated, users are able to interact with the environment through multiple senses. Our brains and bodies begin to experience the virtual environment as real.

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Can we get the immune system to tolerate organ transplants?

July 9 - Currently, people receiving organ transplants must take drugs to suppress the inflammatory immune response that leads to rejection. Even so, almost all recipients eventually lose their transplant. A new approach, which maintains a population of immune cells that naturally temper immune responses, known as Tregs, could greatly enhance people's long-term tolerance for transplants.

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Announcement - LIve BroadcaSt
Wednesday July 04, 2018 from 11:15 to 13:15
President's Plenary & Awards

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Join Nancy Ascher, our TTS President, in celebrating our Vibrant Society and for the unveiling of this year's Medawar Prize Laureates!

The broadcaster has a rewind function so you can join late or watch later in the event the session IS not a convenient time in your country.

(WEDNESDAY JULY 04, 2018 FROM 11:15 TO 13:15 MADRID TIME - UTC/GMT +2 HOURS)

CLICK HERE TO SIGNUP!

CLICK HERE FOR program details 

Transplantation - Just Released!

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Controversies raised, controversies reviewed and controversies resolved. You can chose which you think are which in this packed issue covering all our fields of interest. From noncitizen nonresident deceased donor transplantation in the USA, to the role of photopheresis in BOS.

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TTS MEMBERS - CLICK HERE TO LOGIN YOUR ACCOUNT FOR OPEN ACCESS

Pitt unveils statue of Dr. Thomas Starzl, transplant pioneer

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Joy Starzl sits next to the statue of her late husband, Dr. Thomas Starzl. Starzl was frequently considered the father of organ transplantation for a program he launched at Pitt in 1981. Susan Wagner, the sculptor, sits beside her. (Photo by Samuel Weber | Staff Writer)

Friends, family, university staff and members of the media gathered outside the Cathedral of Learning in full business attire Saturday to honor the memory of the late Dr. Thomas Starzl with a new bronze statue.

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TTS 2018 - Highlighted Corporate Symposium

 

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Transplantation - Featured Article

Submitted by Dr Andrea Schlegel, Editorial Fellow, Transplantation.

Association of Cold Ischemia Time with Acute Renal Transplant Rejection
ostalcioglu M, Kaze AD, Byun BC, et al.
Transplantation. Published online January 18, 2018. doi:10.1097/TP.0000000000002106.

The authors evaluated the impact of cold ischemia time (CIT) and recipient age on acute renal transplant rejections (ARTR) in a retrospective analysis of the UNOS data base; 63 798 deceased donor renal transplants performed between 2000 and 2010 were evaluated. Overall, 6802 kidney recipients (11%) developed an acute rejection; prolonged CIT ( ≥24hours) appeared as independent risk factor, which was even more pronounced in recipients undergoing retransplantation. Moreover, prolonged CIT had increased the risk of death-censored graft loss. In addition, older recipients (≥60 years) had a lower risk of ARTR.

Those data fit well into the overall concept that prolonged CIT induce a more pronounced reperfusion injury, which is linked to an increased innate immune response and higher acute rejection rates.

Older recipients appear to have a less potent immune response with less frequent ARTR.

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In the News

Availability of family and friends key factor in deciding organ transplant suitability

June 28 - This may sanction existing prejudices and widen inequalities in selection process, warn researchers

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Transplanting best practices in INDIA - COmmentary by Sanjay Nagral

June 27 - Heart transplantation has always been in the public eye right from the time Christiaan Barnard performed the first successful human heart transplant in 1967, in Cape Town, Africa. Therefore, controversy in India over a large percentage of foreign nationals receiving cardiac transplants from deceased donors in India is not surprising. This follows a report published by The Hindu (June 12, 2018) based on a leaked WhatsApp message from the head of the National Organ and Tissue Transplant Organisation. However, the debate around it is vital because it is a marker of the fault lines in transplantation policy in India that need immediate correction.

Sanjay Nagral is a surgeon in Mumbai and also performs liver transplantations. He is the chairperson of the Forum for Medical Ethics and a member of the Executive Council of the Declaration of Istanbul Custodian Group. Check out his presentations at TTS 2018 by clicking here!

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