NON-VIRAL INFECTIONS IN TRANSPLANTATION

M.G. Ison, S. Covington, K. Taylor, S. Taranto, K. Parker, E. Blumberg, P. Chin-hong, M. Dimaio, J.P. Gockerman, M. Green, R. Hasz, B. Kubak, D. Lebovitz, T. Pruett, A. Smith, L. Teperman, B. Vasudev, M. Nalesnik
, UNOS, Richmond/VA/UNITED STATES OF AMERICA

Body: Background: Donor-derived disease transmission is increasingly recognized as a source of morbidity and mortality among transplant recipients. OPTN Policy 4.0 currently requires reporting ofdonor-derived events. Methods: All potential donor-derived transmission events (PDDTE) that were reported to the OPTN from 1/1/06 - 10/31/09 were reviewed by the DTAC. These events were categorizedas to the likelihood of being donor-derived and outcomes were assessed. Results: Reports of PDDTE have increased from 7 in 2005 (the first full year data was collected) to 152 in 2009. There were 121reports of malignancy PDDTE with 18 recipients with confirmed transmission and 5 deaths (table 1). There were 196 reports of infectious PDDTE with 54 recipients with confirmed transmission and 22attributable deaths (table 2). Many of the cases remain under investigation so documented transmission and deaths may increase. Conclusions: PDDTE continue to be reported as required by OPTN policy.There are increased numbers of reports suggesting under-reporting. Renal cell carcinoma remains the most frequently reported malignancy. There were more bacterial and fungal infections reported in2009 than in previous years. Enhanced donor screening and communication about donor and recipient conditions may facilitate prevention and early recognition of a PDDTE.

Disclosure: All authors have declared no conflicts of interest.