2015-2017 - Advanced Renal Transplantation - Interactive Teaching Series


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The Challenges in Transplantation

10.1 - The Challenges in Transplantation: Organ Quality Assessment and Preservation

Presenter: Rutger , Ploeg, Oxford, UK
Authors: Rutger Ploeg

Biography

Professor Ploeg began his education at the University of Leiden. During his medical education he followed electives in Indonesia, Toronto and Cambridge. He was trained as a surgeon at Leiden University Medical Centre. During his research fellowship in Madison at the University of Wisconsin with Dr. F.O. Belzer in 1986-1988, he became interested in organ donation, ischemia & reperfusion injury and preservation in transplantation. He was involved in the experimental studies and clinical introduction of the UW solution and received his PhD cum laude at the University of Leiden in 1991.

After mhis clinical ASTS fellowship at the University of Wisconsin Hospital & Clinics from 1991-1993, he was appointed Consultant Surgeon at the University Medical Centre Groningen in the Netherlands and as Professor of Surgery in 2001. In 2002 he became Head of the Divisions of Abdominal Surgery and Transplant Surgery & Organ Donation in Groningen. His professional activities include a broad array of responsibilities both nationally and internationally, and has recently included Board Memberships of Eurotransplant, the Dutch Transplantation Foundation, Associate Editorship for the American Journal of Transplantation and Advisorship to NHSBT in the UK. He also served the European Society for Organ Transplantation as Secretary and was elected President of ESOT in 2009.

In June 2011 he was appointed as Chair in Transplant Biology and Director of Clinical & Translational Research in the Nuffield Department of Surgical Sciences at the University of Oxford. Apart form his research activities, he is a Consultant Transplant Surgeon in the Oxford Transplant Centre. He is currently focusing on the establishment of two consortia: the Consortium on Organ Preservation In Europe (COPE) and on the Consortium on Quality in Organ Donation in the UK.
His research aims are:

  • To increase the number and quality of retrieved organs for transplantation by optimising donor management and resuscitating and preserving marginal organs. 
  • To make previously unusable organs transplantable and increase the “donor pool”. 
  • To identify pathways of injury and apply targeted interventions to repair donor organ injury. 
  • To translate validated experimental methods and technologies into clinical use and best practice protocols. 
  • To identify bio-markers and functional parameters that predict outcome following transplantation. 
  • To attract other groups and attempt to find new innovative ways of resuscitation and regeneration. 
  • To streamline collaboration and dissemination between scientific and clinical experts in academic institutions across the United Kingdom and Europe.

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