2010 - TTS International Congress


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Clinical and Ethical Aspects of Living Donor Transplantation

98.2 - Increasing kidney function in living kidney donors proceeds for a long time after nephrectomy

Presenter: John, Söfteland, Göteborg, Sweden
Authors: Söfteland J., Kvarnström N., Lennerling A., Rizell M., Odén A., Fehrman-Ekholm I.

INCREASING KIDNEY FUNCTION IN LIVING KIDNEY DONORS PROCEEDS FOR A LONG TIME AFTER NEPHRECTOMY

CLINICAL AND ETHICAL ASPECTS OF LIVING DONOR TRANSPLANTATION

J.M. Söfteland1, N. Kvarnström1, A. Lennerling1, M. Rizell2, A. Odén3, I. Fehrman-ekholm1
1Transplantation Centre, Sahlgrenska University Hospital, Göteborg/SWEDEN, 2Transplanation Centre, Sahlgrenska University Hospital, Göteborg/SWEDEN, 3, Statistical, Romelanda/SWEDEN

Body:
Introduction: The long-term consequences of kidney donation in living donors are important issues as the living kidney donor transplantations are increasing world-wide. Methods: The cohort of kidney donors at Sahlgrenska University Hospital in Gthenburg, Sweden who underwent nephrectomy 1965-2005 were re-investigated with questionnaire, evaluation of kidney function, blood pressure and albuminuria. Results: A total of 573 former donors with a mean age of 61 (SD 13) and a mean 14 (SD 9.1) years since donation could be evaluated for kidney function eGFR using MDRD. The mean eGFR was 68 (SD14) mL/min/1.73 m2. When using multiple regression analysis there was a significant correlation (p< 0.0001) with increasing age and decreasing GFR. However, there was also a strong significant correlation (p<0.0001) with time since donation and increasing GFR. When considering ratio of urine albumin-creatinine excretion there was no relation to actual age of the donors. However, with longer time since donation there was an increasing urine albumin excretion (p<0.001) and thus higher albumine creatinine ratio (p< 0.01). The systolic blood pressure increased significantly (p<0.01) but not the diastolic blood pressure. Conclusion: A former kidney donor´s kidney function significantly improves over many years following nephrectomy. We also found that there is an increasing microalbuminuria indicating hyperfiltration effect.

Disclosure: All authors have declared no conflicts of interest.


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