2010 - TTS International Congress


This page contains exclusive content for the member of the following sections: TTS. Log in to view.

Complications Cardiovascular

31.9 - Increased serum angiotensin converting enzyme-2 activity in diabetic kidney transplant (KT) patients with suboptimal graft function.

Presenter: Marisa, Mir, ,
Authors: Soler Romeo M., Riera M., Mir M., Crespo M., Puig J., Pascual J.

INCREASED SERUM ANGIOTENSIN CONVERTING ENZYME-2 ACTIVITY IN DIABETIC KIDNEY TRANSPLANT (KT) PATIENTS WITH SUBOPTIMAL GRAFT FUNCTION.

COMPLICATIONS - CARDIOVASCULAR

M.J. Soler romeo1, M. Riera2, M. Mir1, M. Crespo1, J.M. Puig1, J. Pascual1
1Nephrology, Parc de salut MAR, Barcelona/SPAIN, 2, Fundació IMIM. Parc Salut MAR, Barcelona/SPAIN

Body: Introduction: Angiotensin-converting enzyme (ACE)-2 is the only known active homologue of ACE, part of a balanced system. Whereas ACE promotes the formation of the vasoconstriction peptide Angiotensin II from Angiotensin I, ACE2 degrades Angiotensin II to Angiotensin 1-7, a vasodilator peptide, and Angiotensin I to Angiotensin 1-9. The role of ACE2 in kidney transplant (KT) function is unknown. We previously showed that serum ACE2 activity is increased in male mice and human. The aim of this study is to investigate whether ACE2 activity is altered in KT patients with or without diabetes. In addition, we studied the correlation between serum ACE2 activity and graft function. Methods: ACE2 activity was assessed using a fluorescence assay after anion exchange in 49 male KT patients (age 54 ±12 yr, GFR-MDRD 45.4 ±12.1 ml/min, 44% diabetes, 36% insulin treated, 44% with RAS blockade). CKD-Stage 3 patients (n=18, MDRD 41,1 ± 8,2 ml/min) served as controls. There was no difference in serum ACE2 activity between control and KT patients. Results: Serum ACE2 activity was significantly increased in insulin treated KT patients as compared with non-insulin treated ones (3.63 ± 0.72 vs 1.92 ± 0.22 RFU/L/h, respectively, p <0.05). ACE2 activity correlated inversely with GFR (r= -0.4, p=0.003) and directly with serum creatinine (r=0.3, p=0.02), blood urea (r=0.4, p<0.05) and glycosylated hemoglobin (r=0.4, p<0.05). RAS blockade did not influence serum ACE2 activity. Conclusions: Serum ACE2 activity is increased in insulin treated diabetic KT recipients and it is directly correlated with glycosilated hemoglobin levels. In addition, ACE2 activity is increased when graft function is decreased. Increased ACE2 activity may provide a compensatory role by promoting the degradation of the vasoconstrictor peptide, angiotensin II to angiotensin 1-7, a vasodilator peptide. Figure: Correlation between plasma ACE2 activity and glomerular filtration rate in kidney transplant patients.

Disclosure: All authors have declared no conflicts of interest.


Important Disclaimer

By viewing the material on this site you understand and accept that:

  1. The opinions and statements expressed on this site reflect the views of the author or authors and do not necessarily reflect those of The Transplantation Society and/or its Sections.
  2. The hosting of material on The Transplantation Society site does not signify endorsement of this material by The Transplantation Society and/or its Sections.
  3. The material is solely for educational purposes for qualified health care professionals.
  4. The Transplantation Society and/or its Sections are not liable for any decision made or action taken based on the information contained in the material on this site.
  5. The information cannot be used as a substitute for professional care.
  6. The information does not represent a standard of care.
  7. No physician-patient relationship is being established.

Social

Contact

Staff Directory
+1-514-874-1717
info@tts.org

Address

The Transplantation Society
International Headquarters
740 Notre-Dame Ouest
Suite 1245
Montréal, QC, H3C 3X6
Canada