2011 - ISBTS 2011 Symposium


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Plenary Session III: Intestinal Immunity + Oral Communications 11

13.229 - A positive NOD2 mutation as a risk factor for the development of short bowel syndrome: data from the Tübingen short bowel syndrome cohort

Presenter: Holger, Schaeffler, Tuebingen, Germany
Authors: Holger Schäffler1, Andreas Heil1, Chien Hsieh1, Georg Lamprecht1

229
A positive NOD2 mutation as a risk factor for the development of short bowel syndrome: data from the Tübingen short bowel syndrome cohort

Holger Schäffler, Andreas Heil, Chien Hsieh, Georg Lamprecht

University Hospital Tuebingen, Department of Internal Medicine, Tuebingen, Germany

Introduction: The short bowel syndrome (SBS) is a rare syndrome which may evolve as a consequence of other diseases. The relationship between mutations in the NOD2 (CARD15) gene and the appearance of Crohn’s disease (CD) was discussed in several cohorts.

Objectives: In a retrospective study we examined 75 patients with SBS of different etiology on NOD2 mutation (R702W, G908R and 1007fs), clinical history, small intestinal length, parenteral nutrition (PE) and complications.

Methods and results: Until 12 / 2010, 75 Patients with a SBS were analyzed retrospectively. The following etiologies could be found: mesenterial infarction 33.33% (n = 25), CD 26.67%(n = 20), ileus 12.00% (n = 9) and other etiologies 26.67% (n = 20). The NOD2 status was tested in patients with CD (n = 12 of 20) and Non-Crohn patients (n = 31 of 55). The allele frequency in CD patients was 58.9% compared to 19.4% in the Non-Crohn group (p value 0.01594). These data are higher compared to the literature (CD: 12.7% - 26.9%; Non-diseased group < 7%). The remaining small intestine of CD patients was longer compared to the Non-Crohn group (113, 9±73, 2 cm vs. 75, 2± 59.1 cm, ns). Non-Crohn patients were older compared to CD patients at the diagnosis of SBS (50.55 ± 2.60 years vs 23.9 ± 2.61 years, p < 0.0001). Catheter infections and thrombosis occurred with a frequency of 2.76/1000 days of parenteral nutrition.

Conclusion: In our cohort, we found a higher NOD2 allele frequency in CD as well as Non-CD patients compared to the literature.  


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