Cell Transplant and Regenerative Medicine Society Webinar Presentation - Thursday, November 12, 2026

Frontiers in Organ Engineering: Human Organoids and the Bioartificial Kidney


Thursday, November 12, 2026 - 1:00 PM (Local time in Montreal)
Local time (Corresponding local time at your current location)
The duration of this presentation is scheduled for 60 minutes.

Overview

Dr. Roy will discuss Engineering an Implantable Bioartificial Kidney

Description
Dr. Roy will present an overview of the implantable bioartificial kidney (iBAK), a potential new form of renal replacement therapy for patients with kidney failure. The talk will describe the integration of silicon membrane technology and living renal epithelial cells to provide continuous ultrafiltration and biological kidney functions. Key engineering and biological challenges in developing a fully implantable, blood-compatible system will be discussed. The presentation will review the current status of research and remaining development steps towards clinical translation.
Learning Objectives
  • Describe the design and operating principles of the implantable bioartificial kidney and its intended role in renal replacement therapy
  • Explain how engineered filtration membranes and living renal epithelial cells are integrated to reproduce key filtration and biological functions
  • Summarize the current development status of the iBAK and the major challenges that must be addressed for clinical translation

Dr. Clevers will discuss Modeling development and disease with human organoids

Description
Dr. Clevers will discuss techniques for culturing functional human breast epithelium in three-dimensional (3D) matrices that have been championed for more than 30 years by Mina Bissell. Additionally, around a decade ago, Sasai and colleagues pioneered pluripotent stem cell (PSC)–based technology to create organoids that mirror specific parts of the central nervous system (CNS). Lancaster and Knoblich modified this technology and provided particularly notable examples of “mini-brain” structures. Although PSCs can be used to model everything ranging from tissues to organismal development, adult stem cells (ASCs) can also be isolated to generate organoid models of the primary tissues in which they reside. Specific growth factor cocktails allow long-term expansion of ASC organoids by mimicking the organ stem cell niche, as first established for mouse and human intestine and airway epithelium. The organoid structures generated from PSCs and ASCs reflect crucial tissue features in terms of overall architecture, the collection of differentiated cell types, and tissue-specific function. Organoids thus represent a model system that can be compared to traditional genetically engineered mouse models (GEMMs), cell lines, and patient-derived xenografts (PDXs). As a definition, organoids are microscopic self-organizing, three-dimensional structures that are grown from stem cells in vitro. They recapitulate many structural and functional aspects of their in vivo counterpart organs. This versatile technology has led to the development of many novel human cancer models. It is now possible to create indefinitely expanding organoids starting from tumor tissue of individuals suffering from a range of carcinomas. Alternatively, CRISPR-based gene modification allows the engineering of organoid models of cancer through the introduction of any combination of cancer gene alterations to normal organoids. When combined with immune cells and fibroblasts, tumor organoids become models for the cancer microenvironment enabling immune-oncology applications. Emerging evidence indicates that organoids can be used to accurately predict drug responses in a personalized treatment setting. Dr. Clevers will illustrate the current state and future prospects of the rapidly evolving tumor organoid field through examples from his lab.
Learning Objectives
  • Understand how iPSC organoids are created
  • Understand how tissue stem cell organoids are created
  • Understand that added levels of complexity (adding immune cells, blood vessels) bring the models closer to the (patho-)physiological situation but come at a cost

CTRMS President-Elect
Alice Tomei, USA
Moderator
Bio
David Lott, USA
Moderator
Bio
Rohan Paul, USA
Moderator
Bio
Shuvo Roy, PhD, USA
Speaker
Bio
Hans Clevers MD, PhD, The Netherlands
Speaker
Bio

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Contact

Staff Directory
+1-514-874-1717 x216
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Address

Cell Transplant and Regenerative Medicine Society
c/o The Transplantation Society
740 Notre-Dame Ouest
Suite 1245
Montréal, QC, H3C 3X6
Canada