Trainee Track Webinar Wednesday, November 22, 2017
Trainee Track Webinar
Epitope Matching: What is it, and what is its relevance?
Wednesday, November 22, 2017, 11am EST (Montreal time)
Peter Nickerson, BSc (Med), MD, FRCPC, FCAHS
Robert Liwski, MD, PhD, FRCPC
Adequacy of immunosuppression is central to holding the alloimmune response in check. Clinicians and patients constantly seek to lower immunosuppressive therapy to minimize the risk for serious adverse events or avoid annoying side-effects leading to clinician-guided under immunosuppression and patient nonadherence. Unfortunately, at present there is no validated predictive biomarker to inform clinicians who can and cannot be safely minimized. The risk of minimization is de novo DSA resulting in antibody-mediated rejection, transplant glomerulopathy and premature graft failure. Moreover, once this process is underway, at present physicians have no effective therapy to turn it off. In the last few years it has been appreciated that computational approaches predicting potential antibody binding epitopes on the mismatched donor and the recipient HLA molecules can be used to predict alloimmune risk for de novo DSA, late acute rejections and graft failure. If this is further validated, then we may have for the first time a predictive biomarker able to aid clinicians safely personalize immunosuppressive therapy.
Peter Nickerson - Biography:
Dr. Peter Nickerson is a Distinguished Professor of Internal Medicine and Immunology and the Vice-Dean Research, Rady Faculty of Health Sciences at the University of Manitoba. He is the Medical Director of Transplant Manitoba and the Medical Advisor, Organ Donation and Transplantation Division, Canadian Blood Services (CBS).
Dr. Nickerson holds the Flynn Family Chair in Renal Transplantation at the University of Manitoba. Funded by the CIHR and NIH, his research program focuses on mechanisms underlying acute and chronic transplant rejection; developing non-invasive techniques for the diagnosis of renal allograft rejection; and health care system design to enhance access to transplant.
Robert Liwski - Biography:
Dr. Liwski obtained his PhD in Transplantation Immunology in 1999, his MD degree in 2003 and completed his fellowship training in Hematological Pathology in 2006, all at Dalhousie University. His research interests include transplantation immunology, ischemia reperfusion injury and optimization of diagnostic testing in transplantation. Dr. Liwski has developed several optimized HLA antibody testing methods including the Halifax/Halifaster flow crossmatch protocols and the Rapid Optimized Single Antigen Bead (ROB) assay. He was awarded the Canadian Association of Pathologists Junior Scientist Award for his research investigating the role of activated protein C in prevention of ischemia reperfusion injury and cancer metastasis.
Wednesday, November 22, 2017, 11am EST (Montreal time)
|Accra||Wed 16:00||Casablanca||Wed 16:00||Kolkata||Wed 21:30||Reykjavik||Wed 16:00|
|Addis Ababa||Wed 19:00||Chicago||Wed 10:00||Kuala Lumpur||Thu 00:00||Rio de Janeiro *||Wed 14:00|
|Adelaide *||Thu 02:30||Copenhagen||Wed 17:00||Kuwait City||Wed 19:00||Riyadh||Wed 19:00|
|Algiers||Wed 17:00||Dallas||Wed 10:00||Kyiv||Wed 18:00||Rome||Wed 17:00|
|Almaty||Wed 22:00||Dar es Salaam||Wed 19:00||La Paz||Wed 12:00||Salt Lake City||Wed 09:00|
|Amman||Wed 18:00||Darwin||Thu 01:30||Lagos||Wed 17:00||San Francisco||Wed 08:00|
|Amsterdam||Wed 17:00||Denver||Wed 09:00||Lahore||Wed 21:00||San Juan||Wed 12:00|
|Anadyr||Thu 04:00||Detroit||Wed 11:00||Las Vegas||Wed 08:00||San Salvador||Wed 10:00|
|Anchorage||Wed 07:00||Dhaka||Wed 22:00||Lima||Wed 11:00||Santiago *||Wed 13:00|
|Ankara||Wed 19:00||Doha||Wed 19:00||Lisbon||Wed 16:00||Santo Domingo||Wed 12:00|
|Antananarivo||Wed 19:00||Dubai||Wed 20:00||London||Wed 16:00||São Paulo *||Wed 14:00|
|Asuncion *||Wed 13:00||Dublin||Wed 16:00||Los Angeles||Wed 08:00||Seattle||Wed 08:00|
|Athens||Wed 18:00||Edmonton||Wed 09:00||Madrid||Wed 17:00||Seoul||Thu 01:00|
|Atlanta||Wed 11:00||Frankfurt||Wed 17:00||Managua||Wed 10:00||Shanghai||Thu 00:00|
|Auckland *||Thu 05:00||Guatemala City||Wed 10:00||Manila||Thu 00:00||Singapore||Thu 00:00|
|Baghdad||Wed 19:00||Halifax||Wed 12:00||Melbourne *||Thu 03:00||Sofia||Wed 18:00|
|Bangalore||Wed 21:30||Hanoi||Wed 23:00||Mexico City||Wed 10:00||St. John's||Wed 12:30|
|Bangkok||Wed 23:00||Harare||Wed 18:00||Miami||Wed 11:00||Stockholm||Wed 17:00|
|Barcelona||Wed 17:00||Havana||Wed 11:00||Minneapolis||Wed 10:00||Suva *||Thu 05:00|
|Beijing||Thu 00:00||Helsinki||Wed 18:00||Minsk||Wed 19:00||Sydney *||Thu 03:00|
|Beirut||Wed 18:00||Hong Kong||Thu 00:00||Montevideo||Wed 13:00||Taipei||Thu 00:00|
|Belgrade||Wed 17:00||Honolulu||Wed 06:00||Montréal||Wed 11:00||Tallinn||Wed 18:00|
|Berlin||Wed 17:00||Houston||Wed 10:00||Moscow||Wed 19:00||Tashkent||Wed 21:00|
|Bogota||Wed 11:00||Indianapolis||Wed 11:00||Mumbai||Wed 21:30||Tegucigalpa||Wed 10:00|
|Boston||Wed 11:00||Islamabad||Wed 21:00||Nairobi||Wed 19:00||Tehran||Wed 19:30|
|Brasilia *||Wed 14:00||Istanbul||Wed 19:00||Nassau||Wed 11:00||Tokyo||Thu 01:00|
|Brisbane||Thu 02:00||Jakarta||Wed 23:00||New Delhi||Wed 21:30||Toronto||Wed 11:00|
|Brussels||Wed 17:00||Jerusalem||Wed 18:00||New Orleans||Wed 10:00||Vancouver||Wed 08:00|
|Bucharest||Wed 18:00||Johannesburg||Wed 18:00||New York||Wed 11:00||Vienna||Wed 17:00|
|Budapest||Wed 17:00||Kabul||Wed 20:30||Oslo||Wed 17:00||Warsaw||Wed 17:00|
|Buenos Aires||Wed 13:00||Karachi||Wed 21:00||Ottawa||Wed 11:00||Washington DC||Wed 11:00|
|Cairo||Wed 18:00||Kathmandu||Wed 21:45||Paris||Wed 17:00||Winnipeg||Wed 10:00|
|Calgary||Wed 09:00||Khartoum||Wed 18:00||Perth||Thu 00:00||Yangon||Wed 22:30|
|Canberra *||Thu 03:00||Kingston||Wed 11:00||Philadelphia||Wed 11:00||Zagreb||Wed 17:00|
|Cape Town||Wed 18:00||Kinshasa||Wed 17:00||Phoenix||Wed 09:00||Zürich||Wed 17:00|
|Caracas||Wed 12:00||Kiritimati||Thu 06:00||Prague||Wed 17:00|
* = Adjusted for DST or summer time (11 places).
Wed = Wednesday, November 22, 2017 (123 places).
Thu = Thursday, November 23, 2017 (20 places).
UTC (GMT/Zulu)-time: Wednesday, November 22, 2017 at 16:00:00
UTC is Coordinated Universal Time, GMT is Greenwich Mean Time.