In The News - Volume 1 - Issue 6 - April 4, 2015

Kidney transplant survival rate found worse in recipients with HCV vs. HIV
Kidney transplant recipients that were positive for HIV had a greater survival rate vs. kidney transplant recipients with hepatitis C virus infection and recipients coinfected with HIV and hepatitis C virus infection, according to new study data. [more]

Broad Institute-MIT team identifies highly efficient new cas9 for in vivo genome editing
April 1 - MIT AND HARVARD - A collaborative study between researchers from the Broad Institute of MIT and Harvard, Massachusetts Institute of Technology, and the National Center for Biotechnology Information of the National Institutes of Health (NIH-NCBI) has identified a highly efficient Cas9 nuclease that overcomes one of the primary challenges to in vivo genome editing. This finding, published today in Nature, is expected to help make the CRISPR toolbox accessible for in vivo experimental and therapeutic applications. [more]

Haptoglobin Enhances Cardiac Transplant Rejection
April 1 - Yale News - The protein haptoglobin boosts inflammation in transplanted hearts, reducing their survival, according to a study led by Yale researchers. The finding may help identify new anti-inflammatory therapies to enhance organ transplant survival. [more]

Clinical trial uses patients' own cells for personalized treatment after bone marrow transplant
April 1 - Emory - An innovative clinical trial using the science of "personalized" cellular therapy has begun enrolling children and adults suffering from graft-versus-host-disease (GVHD), a life-threatening complication of bone marrow transplantation in which donor immune lymphocytes attack the organs of the bone marrow transplant recipient. [more]

The Molecular Landscape of Antibody-Mediated Kidney Transplant Rejection: Evidence for NK Involvement Through CD16a Fc Receptors
The recent recognition that antibody-mediated rejection (ABMR) is the major cause of kidney transplant loss creates strong interest in its pathogenesis [more]

Innovative strategies needed to address the US transplant organ shortage
March 31 - MedicalXpress - As the United States faces transplant waiting lists that continue to grow longer over time, there is increasing debate about the proper way to incentivize living donations. Transplant professionals are trying to find ways to eliminate any financial disincentives without crossing the line to paying for organs. A new article published  highlights possible solutions discussed by leaders within the Transplant Community. [more]

Pulmonary Fibrosis, Emphysema Caused By Stem Cell Failure Due to Shortened DNA Component
April 2 - pulmonaryfibrosisnews - In a new study entitled “Telomere dysfunction causes alveolar stem cell failure,” a research team identified that short telomeres in lung stem cells induce stem cell failure, leading to the underlying cause of diseases like pulmonary fibrosis and emphysema. The study was published in the journal Proceedings of the National Academy of Sciences. [more]

Nano vehicles: Novel strategy of mRNA-based gene therapy
Gene therapy is a technique of using genes or nucleic acids to treat or prevent a disease. Gene therapy is a promising treatment for genetic disorders, certain cancers, muscular and neurological disorders. In gene therapy, nucleic acid polymers packaged within a vector are delivered into the cells. These polymers are either expressed as proteins, interfere with protein expression, or possibly correct genetic mutations. [more]