IPTA December 2017 Newsletter

ipta newsletter

Holiday Greetings | Donate to IPTA Now! | Announcement: IPTA 2018 Symposium in Organ Transplantation in Children | Ethical Case Request | Announcement of New Editors | Writing Project Proposal Form | IPTA ID Committee Update | PJP surveyRecent publications of interest in the arena of antibody mediated rejection | IPTA Reduced Dues for 2018!

Holiday Greetings

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On behalf of the leadership of the International Pediatric Transplant Association, may you have a peaceful, joyful holiday season. Thank you for dedicating this past year to your patients and families, and thank you for your tireless efforts to advocate for all children who need transplantation. We look forward to serving you in 2018.

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Anne Dipchand
President of IPTA

Donate to IPTA Now!

donate

Donate to IPTA Now! Your donation will be used to help IPTA to promote the advancement of the science and practice of transplantation in children worldwide and to serve as a unified voice for the special needs of pediatric transplant recipients.

DONATE NOW!

Announcement: IPTA 2018 Symposium in Organ Transplantation in Children

The International Pediatric Transplant Association is proud to feature a special section activity: the 2018 Symposium in Organ Transplantation in Children: An educational forum for physicians, surgeons, and allied health professionals.

The focus of this symposium is aimed at clinical and research fellows in pediatric solid organ transplantation, as well as residents, and other allied health professional or non-physician trainees who are planning a career in pediatric transplantation.

The symposium will also provide state of the art information to established physicians, surgeons and allied health professionals who participate in the care of children before or after solid organ transplantation. In this case, a registration fee of $150/ person applies. Maximum capacity for established practitioners will be 50.

Read More...

Pneumocystis jiroveci (PJP) survey

PJP survey

Pneumocystis jiroveci (PJP) remains an import pathogen among organ transplant recipients. While there are published guidelines for PJP prophylaxis following transplantation, in practice, there is likely wide variability in the individual approach to prophylaxis. To better clarify the current practice among transplant centers, we are conducting a survey to assess the use of PJP prophylaxis following pediatric solid organ transplant recipients. The link to the survey is included in this edition of the Newsletter. It is approximately 12 questions and should take fewer than 10 minutes to complete.

We appreciate you taking the time to COMPLETE THE SURVEY, and all responses will remain anonymous.

Ethical Case Request

Do you have cases that keep you up at night? Please share them with us!

Organ transplantation, particularly in children, is a process fraught with ethical questions. We routinely make decisions that can greatly impact our patients' lives with far from perfect information. How poor a prognosis does a patient have to have before he or she is no longer a transplant candidate? How should we weigh non-medical factors when making decisions? What allocation systems should we advocate for or emulate?

Read More...

Announcement of New Editors

IPTA is pleased to announce the appointment of two new editors for its journal, Pediatric Transplantation: Drs. Burkhard Tönshoff and Sharon Bartosh.

  editors

IPTA is pleased to announce the appointment of two new editors for its journal, Pediatric Transplantation: Drs. Burkhard Tönshoff and Sharon Bartosh.

  editors

editors

IPTA is pleased to announce the appointment of two new editors for its journal, Pediatric Transplantation: Drs. Burkhard Tönshoff and Sharon Bartosh.

IPTA is very grateful to Dr. Steven Webber for all of his service to IPTA. He was a founding Council member of IPTA, served as its third President, and for the last 5 years has served as Editor-in-Chief of Pediatric Transplantation.

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Proposals for ipta-sponsored Writing Projects

The International Pediatric Transplant Association is dedicated to advancing the science and practice of pediatric transplantation worldwide, in order to improve the health of all children who require such treatment. To achieve this, part of our mission is to generate and disseminate information in the field of pediatric transplantation to our members and to the transplant community worldwide. This is primarily accomplished through the publication of important original research, review articles, commentaries and summaries to our journal, Pediatric Transplantation.

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IPTA Infectious Diseases Committee Update

ID Committee

The IPTA Infectious Diseases (ID) Committee continues to be actively involved in generating information and guidance to benefit our members and the children that we care for. In many cases, members of the committee are collaborating with other members of IPTA to carry out these projects and develop manuscript and guidance. Amongst our current initiatives, the Committee is working with members of IPTA who participated in the 3rd TTS Consensus Conference on CMV this last spring to provide a pediatric perspective on the soon to be published updated CMV Guidelines. It is anticipated that this will follow a “Question and Answer” format and will be published in Pediatric Transplantation in 2018.

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Recent publications of interest in the arena of antibody mediated rejection

  •  Jordan, SC et al.  IgG Endopeptidase in Highly Sensitized Patients Undergoing Transplantation.  N Engl J Med. 377: 5: 2017

    This is a report of 25 highly sensitized patients transplanted in 2 countries (Sweden, USA), with IdeS in an open label phase 1-2 trial of desensitization and transplant.   IdeS, a cysteine protease, is an IgG-degrading enzyme derived from Step pyogenes.  It is an endopeptidase that cleaves human IgG into F(ab’)2 and Fc fragments inhibiting complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity.  Immunosuppression protocols differed significantly between the 2 countries.  IdeS was shown to reduce or eliminate donor-specific antibodies and permitted HLA-incompatible transplantation in 24 of the 25 patients.  There was a single allograft loss due to hyperacute rejection and 5 patients developed antibody mediated rejection.  
  • Choi J., et al.    Assessment of Tocilizumab (Anti-Interleuken-6 Receptor Monoclonal) as a Potential Treatment for Chronic Antibody-Mediated Rejection and Transplant glomerulopathy in HLA-Sensitized Renal Allograft Recipients.  AJT. 17. 2017

    This is a single center, open label report of 36 renal transplant patient with cAMR plus DSAs and transplant glomerulopathy who were treated as rescue therapy (progressive dysfunction having failed treatment with IVIg plus rituximab with or without PLEX), with monthly infusions of the anti-IL-6 receptor monoclonal antibody tocilizumab.  Tocilizumab binds to both soluble and membrane-bound forms of the IL-6R and is approved by the FDA for treatment of rheumatoid arthritis and juvenile idiopathic arthritis.  Significant reductions in DSAs and stabilization of renal function were seen at 2 years.   Confirmation of this uncontrolled report, of course is necessary. 
  • Clayton PA, Coates P.  Are Sensitized Patients Better off with a Desensitization transplant or waiting on dialysis?   Kidney International. 91. 2017

    Although this article refers to 2 manuscripts (N Eng J Med: 374: 940-959. 2016 and Lancet; 389:727-734. 2017) which report conflicting results regarding the survival benefit of transplantation in sensitized adult kidney transplant patients, the questions addressed are not different for children.  Wait for a well matched kidney or desensitize and attempt transplant??

IPTA Reduced Dues for 2018!

BREAKING NEWS:

REDUCED DUES FOR 2018!

 

MEMBER LEVEL 1 Year (USD) 2 Years (USD)
Physicians $225 $200 (USD) $400 $380 (USD)
Trainees $115 $75 (USD) $210 $140 (USD)
Allied Health $115 $100 (USD) $210 $190 (USD)
Emerging Economy 55 (USD) 100 (USD)

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IPTA March 2018 Newsletter

ipta newsletter

Donate to IPTA Now! | IPTA 2018 Symposium in Organ Transplantation in Children | IPTA Ethics Survey! | Literary Highlights | 10th Congress on Pediatric Transplantation (IPTA 2019) | Question Bank | Peer Mentoring | Career Development and Mentoring | Pneumosystis Jiroveci (PJP) Survey – Last Chance! | Guidance on the Use of Live Vaccines in Solid Organ Transplantation | Pediatric Transplantation

ipta donate

Donate to IPTA Now! Your donation will be used to help IPTA to promote the advancement of the science and practice of transplantation in children worldwide and to serve as a unified voice for the special needs of pediatric transplant recipients.

DONATE NOW!

IPTA 2018 Symposium in Organ Transplantation in Children

The International Pediatric Transplant Association is proud to feature a special section activity: the 2018 Symposium in Organ Transplantation in Children: An educational forum for physicians, surgeons, and allied health professionals.

The focus of this symposium is aimed at clinical and research fellows in pediatric solid organ transplantation, as well as residents, and other allied health professional or non-physician trainees who are planning a career in pediatric transplantation.

The symposium will also provide state of the art information to established physicians, surgeons and allied health professionals who participate in the care of children before or after solid organ transplantation. In this case, a registration fee of $150/ person applies. Maximum capacity for established practitioners will be 50.

Read More...

IPTA Needs You!

ID Committee

Welcome to the introduction of the IPTA Ethics committee which is a new group that was formed at IPTA 2017 in Barcelona. We are currently working on a survey, which aims to explore the ethical issues within the paediatric transplant community across the world. This is based on original work in the adult transplant population through TTS and we have developed this for paediatric practice through IPTA.

We aim to survey those who are IPTA members or those who have attended IPTA conferences. We want to hear from all members of the multi-disciplinary teams and from all grades – even professors can give their opinion. However, any survey is only as good as the completed responses from the members and so we are very grateful to you all for spending time doing this survey.

Please find below the website address for the SurveyMonkey questionnaire.

Complete the Survey

We will let you know the results as soon as we have them available.

Many thanks for all your help,

Dr Stephen Marks, Consultant Paediatric Nephrologist and Principal Investigator
Dr Debra Lefkowitz, Co-Principal Investigator
Dr Richard Trompeter, Chair of IPTA Ethics Committee
Drs Anne Dipchand and Mignon McCulloch, IPTA President and President-Elect

Literary Highlights

With each newsletter, we will continue to have an IPTA member highlight important recent publications in an area of general interest. This newsletter’s literary highlights come from Rohit Kohli, MBBS, MS, Chief, Division of Gastroenterology, Hepatology and Nutrition, Children’s Hospital of Los Angeles.

  1. Allway R et al. (2017) Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: A randomized, crossover clinical trial. PLoS Med; 14(11): e1002428.

    Brand Tacrolimus vs. Generic Bioequivalence A recent study in PLoS Medicine reports on the bioequivalence between innovator (brand) and generic tacrolimus in adult liver and kidney transplant recipients. This was an 8 week randomized, crossover clinical trial with 35 renal transplant recipients and 36 liver transplant recipients. Within-subject variability was similar for the area under the curve (AUC) (range 12.11-15.81) and the concentration maximum (Cmax) (range 17.96-24.72) for all products. The within-subject variability was utilized to calculate the scaled average bioequivalence (SCABE) 90% confidence interval. The calculated SCABE 90% confidence interval was 84.65%-118.13% and 80.00%-125.00% for AUC and Cmax, respectively. Similar work in pediatric recipients is needed to address the specific pharmacokinetics of children and adolescents.

  2. Hsu EK et al. Analysis of Liver Offers to Pediatric Candidates on the Transplant Wait List
    Gastroenterology. 2017 Oct;153(4):988-995. doi: 10.1053/j.gastro.2017.06.053.

    Analysis: Pediatric liver offers on wait list in the USA A retrospective review of the US liver transplant wait-list over seven years resulted in identification of data for 3852 pediatric liver transplant recipients. To allocate liver donor organs to pediatric recipients the US system uses the Pediatric Endstage Liver Disease (PELD) scoring system and in addition a system for exceptions to the PELD is allowed through appeal. The authors report that amongst all the pediatric liver transplant candidates in the US that they reviewed, children who died or were delisted received a median 1 pediatric liver offer and waited a median of 33 days. Most importantly, of the children who died or were delisted, 45% died or were delisted with no offers. In a developed system such as that led by the United Network for Organ Sharing (UNOS) the death of a pediatric patient on the wait list with no offers is unconscionable. Therefore prioritization in the allocation for children and the future development of further improved risk stratification systems is required to eliminate wait-list mortality among children.

ipta 2019

Question Bank

QB

Want to stay up to date on transplantation? Want to test your knowledge? Here’s your chance! Introducing a new IPTA member benefit, the IPTA question. Members will have access to new questions with each newsletter with additional questions and answers available on the website. Each question will be accompanied by references to explain the correct and incorrect answers. It can be used as a teaching tool for students, residents and fellows as well.

Click Here to Proceed

Peer Mentoring

PJP survey

Dear IPTA Colleagues,

The Publications and Communications Committee is happy to announce a new Peer Mentoring initiative. The overarching goal of this new initiative is to facilitate and improve the quality of publications being sent by our membership to transplant journals, especially Pediatric Transplantation. One means of achieving this goal is to assist our membership, especially junior faculty and faculty from emerging transplant communities, in manuscript preparation. This will allow for these members to have dialogue with those experienced in the publication process prior to final submission.

We are seeking interested individuals who would be willing to help out with this new initiative. Responsibilities would include providing reviewer style feedback to the mentee prior to manuscript submission, and being available for subsequent questions. All members, including non-physician members, are encouraged to participate.

If interested, please send your name, email, and any specific areas of research focus to This email address is being protected from spambots. You need JavaScript enabled to view it. .

Thank you in advance for your support,

Peer Mentoring Workgroup, IPTA
Chesney Castleberry, Workgroup Leader

Career Development and Mentoring

While watching televised coverage of the Winter Olympics this year, my daughter asked me whether or not she could try the skeleton event. The skeleton, for those unaware, involves placing oneself on a sled and sliding down a bobsled track at speeds up to 80 miles/hr or 130 km/hr…. headfirst. My daughter is 5 years old. So, my typical parental answer of course was “maybe when you are older” – hoping she will forget and never ask me again. While thinking later about my answer, I realized that at some point, each one of those Olympic competitors had somebody say “yes” when they asked the same question and there was a team of people who identified their strengths and weaknesses, encouraged them, coached them, and they became Olympians.

All of us have difficult moments early in our careers: The first patient that presents in a way different from anything you saw during your training (if this hasn’t happened to you yet, trust me, it will happen). The first difficult decision that you had to make about whether or not to list a child for transplant, and the conversation that had to take place with the child and their family. The first time a patient had a poor outcome on your watch. Even making the decision to pursue highly specialized training in transplant medicine.

In all of these situations a mentor can be extremely valuable. Having someone to call to discuss that difficult patient, or serve as a sounding board when all isn’t going well in your position. The beautiful thing about pediatric transplantation, is that we are a small, tight-knit community of professionals who constantly work together to improve outcomes in children after transplant. During my first trip to an IPTA meeting, I had the opportunity to discuss difficult cases with senior colleagues in pediatric heart transplantation and have been fortunate to be able to foster these relationships: emails about difficult clinical situations, advice about a research project, career advice. There is no limit to the value of a good mentor.

I am proud to say that the different committees of IPTA all understand the value of good mentorship, and are all tackling this idea of mentorship for our members. The Education Committee is publishing quarterly literary highlights in this newsletter, bringing attention to important papers that may not have caught our attention in the prior 3 months. The Outreach Committee is working on assessing outcomes of IPTA outreach activities and finding the most effective ways to bring transplant expertise to as many children as possible. The Publications and Communications Committee is planning a Peer-Mentoring workshop at the next IPTA Congress in Vancouver, and is starting work on an official program for mentoring writers to facilitate and improve the quality of publications submitted to our journal. The IPTA Council and the Education Committee have continued to support education activities such as the 2018 Symposium in Organ Transplantation in Children, a meeting focused on educating junior faculty and trainees. Please see the top portion of this newsletter for more information about this amazing educational opportunity.

Starting your career in pediatric transplantation will be scary at times - there’s really no way around it. But, with a little help from your friends and mentors, we can continue to bring high quality care to the children of the world who need transplantation. Sometimes, all we need is someone to say “yes” and give us a little push down the track….

I look forward to seeing all of you in San Juan and in Vancouver!

Jonathan N. Johnson, MD
Co-Chair, Publications and Communications Committee, IPTA

Pneumosystis Jiroveci (PJP) Survey – Last Chance!

PJP survey

Pneumocystis jiroveci (PJP) remains an important pathogen among organ transplant recipients. While there are published guidelines for PJP prophylaxis following transplantation, in practice, there is likely wide variability in the individual approach to prophylaxis. To better clarify the current practice among transplant centers, we are conducting a survey to assess the use of PJP prophylaxis following pediatric solid organ transplant recipients. The link to the survey is included in this edition of the Newsletter. It is approximately 12 questions and should take fewer than 10 minutes to complete.

We appreciate you taking the time to COMPLETE THE SURVEY, and all responses will remain anonymous.

Guidance on the Use of Live Vaccines in Solid Organ Transplantation

IPTA partnered in this recent highly successful collaborative initiative held in Toronto on Feb 22-23 with world-leading experts on live vaccine use in pediatric solid organ transplantation.  The aim is to develop an international consensus protocol to include standards relating (but not limited) to immunologic evaluation pre-vaccination, timing pre- and post-transplant for vaccination, and the optimal safety surveillance system.  We expect that the meeting will result in a document and publication that will be used widely around the world.  Stay tuned for further updates!

Do not miss a single issue of Pediatric Transplantation! In order to get email reminders of new articles or issues, IPTA members must activate their journal content alerts. Click on the link below to log into your account and activate these alerts. 

Click here to activate content alerts from journal

IPTA September 2017 Newsletter

ipta newsletter

IPTA 2017 Congress | Ethics Case Study 1 | Ethics Case Study 2 | Literary Highlights | Ethics Committee | Education Committee | Publications & Communications Committees | Membership Committee | Allied Health Professional Committee | Outreach Committee | ID Committee

IPTA 2017 Congress

ipta2017

IPTA Council – Barcelona, Spain

The 9th Congress of the International Pediatric Transplant Association (IPTA) took place in Barcelona, Spain, from May 27-30, 2017 and was a great success both in terms of its excellent attendance and its scientific quality. Topics being addressed were updates and new data from ongoing pediatric transplant clinical trials (CTOTC), long-term complications following transplantation, standards for surveillance and treatment of infections in transplantation, perspectives in immune tolerance, up-to-date data from important registries, new and emerging immunosuppressive agents, ethical dilemmas in pediatric transplantation, devices used to support transplantation, issues in noncompliance and transfer of care, just to name a few.

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Ethical Case Studies

IPTA is pleased to introduce Case Studies dealing with key ethical issues in our quarterly newsletters to spark awareness, education and discussion. These will be spearheaded by the IPTA Ethics committee.

Case Study 1

Introduction

An eight-year-old girl with end-stage kidney disease secondary to Finnish type congenital nephrotic syndrome initially managed with daily albumin infusions requiring peritoneal dialysis from nine months of age followed by bilateral retroperitoneal nephrectomies at ten months of age. In her first two years of life, she had numerous treatment-related problems including multiple episodes of sepsis, requiring changes of central venous catheters; a chronically leaking gastrostomy (which eventually was removed) and severe gastro-oesophageal reflux disease, hypothyroidism, renal osteodystrophy and hypertension secondary to fluid overload. Following several episodes of severe peritonitis, including MRSA peritonitis, her peritoneal dialysis catheter was removed and subsequently an abdominal collection was drained. Haemodialysis was then commenced, but venous access proved to be difficult and became increasingly so over the forthcoming months.

A venogram revealed many occluded and stenosed veins; the thromboses in the superior vena cava and subclavian veins were identified as compromising catheter patency. At 19 months, she was admitted urgently to hospital with physical signs of acute sepsis (fever, tachycardia) associated with marked abdominal distension and tenderness. She failed to respond to standard antibiotic therapy and was found to have vegetation on the tricuspid valve within the right ventricle, suggestive of infective endocarditis, but without evidence of pulmonary emboli. She was treated with six weeks of intravenous antibiotics, and a permanent haemodialysis catheter was inserted. At this stage, our patient had suffered episodes of severe MRSA peritonitis associated with staphylococcal bacterial endocarditis, necessitating the removal of her peritoneal catheter; peritoneal dialysis was no longer an option. Haemodialysis was also problematic because of extreme difficulty in vascular access; it also became apparent that a vascular graft for haemodialysis would not be successful.

Unfortunately, there were no transplant options as she had been on call for over a year for a deceased donor and there was no living donor as her mother could not donate for medical reasons and her father, although a suitable match, stated he was unable to donate.

What medical care options exist for this patient?
What are the ethical considerations?

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Case Study 2

A 3 year old girl was diagnosed with nephrotic syndrome secondary to FSGS. She was initially treated with steroids and Cytoxan later converted to cyclosporine A. Despite treatment she slowly deteriorated into ESRD and started dialysis. At 10 years of age, she underwent a deceased donor kidney transplantation and was managed with triple immunosuppressive protocol (CyA, MMF and steroids) without pre-transplant plasmapheresis (PP).

At the 14th post op day with creatinine levels dropping to 1.0mg/dL she developed proteinuria of 17g//24hr. and was placed on PP sessions 3 times/ week followed by Rituximab (single dose of 375mg/m2). The following months despite aggressive continuous sessions of PP maintaining her protein urine level < 10g/day she developed hypoalbuminemia (albumin levels 2.2g/dl) associated with severe leg edema, skin infection and convulsive disorder secondary to PRESS. At six months after transplant her mother requested to discontinue immunosuppressive treatment and she returned to dialysis.

Six years later she was fed up with dialysis and asked to be listed for a second transplant.

At this stage would you consider a second transplant using one of the parents who was a match donor knowing that this scenario might be associated with a high risk of recurrence?

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Literary Highlights

With each newsletter, we plan to have an IPTA member highlight important recent publications in an area of general interest. Since all our members have access to our journal PEDIATRIC TRANSPLANTATION, this feature will highlight reports, from other journals, which may not be readily available to all our members. As with this inaugural edition, reports of adult data that may have relevance to our members may also be included. This newsletters’ literary highlights come from Sharon Bartosh, M.D., Chief, Pediatric Nephrology, American Family Children’s Hospital, University of Wisconsin.

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IPTA Committees 2017-2019

Much of the work of IPTA is can only be done through the contributions of our committees. We would like to introduce you to the IPTA committees for 2017-2019 and share their current initiatives.

Allied Health Professional (AHP) Committee

2017-2019 Initiatives

The AHP committee is in the process of carrying out a survey to describe the demographics and interests of transplant allied health professionals. The goal is to determine how the allied health committee can encourage and increase IPTA membership, as well as foster a greater involvement in allied health activities and committee work within the organization. The committee will revise and expand the Allied Health Professional page on the IPTA website to include a mission statement, a description of the AH community in transplant and their specific roles in caring for pediatric transplant patients, committee initiatives, membership benefits, quotes from members and how to become a member. The committee also plans to explore a link for networking and the ability to post questions to other AH members. The committee plans to develop an article for publication in Pediatric Transplantation on a contemporary topic that is relevant to the AHP community in addition to participating in review of the UNOS parent manual.

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Education Committee

2017-2019 Initiatives

The Education committee has already participated in the IPTA review of the UNOS parent material and is in the process of a survey related to the Postgraduate Course of the IPTA 9th Congress in order to inform further course development. The Education committee will be developing the curriculum for the IPTA Fellows meeting in November 2018 and the renamed postgraduate course “Foundations in Transplantation” for the IPTA 10th Congress in Vancouver in 2019. Other exciting initiatives will be forthcoming this Fall.

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Ethics Committee

2017-2019 Initiatives

The Ethics committee is the newest IPTA committee that has been formed to address the increasing ethical awareness in pediatric solid organ transplantation. As they develop their initiatives as a new committee, the group plans to raise awareness and educate by contributing cases to the IPTA newsletter (see this issue of the newsletter for their first contribution). In addition, to build upon a recent TTS initiative, they will be editing the recent TTS Ethics Survey for pediatrics with a goal to circulate it in early 2018 and to use the information gathered as a foundation for further initiatives moving forward.

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Infectious Disease Committee

2017-2019 Initiatives

The ID committee has a number of active initiatives involving assessing current practice and developing consensus recommendations for publication in Pediatric Transplantation including 1) evaluation and approach to the presence of active infection in the potential pediatric transplant recipient, 2) status of the use of live vaccines after pediatric solid organ transplantation, and 3) pneumocystis prophylaxis strategies, in addition to a yearly Influenza Update. The ID Committee is proposing to develop a commentary to the TTS CMV Guidelines (currently in progress) specific to the pediatric perspective. This would highlight changes to both the overall document as well as to the pediatric section and its recommendations. In addition, the Committee hopes that the proposed commentary could identify ongoing pediatric specific gaps in the data with a goal of hoping to target future. Looking ahead, the ID committee is exploring the development of PTLD practice recommendations potentially including diagnosis, management and prevention. These are just some of the exciting initiatives coming out of the ID committee.

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Membership Committee

2017-2019 Initiatives

The Membership Committee will be exploring a new dues structure for IPTA which is long overdue. This will take into consideration many different factors including our diverse membership of an international nature, the need to foster collaboration at all levels of pediatric transplantation, the need to develop junior people to pursue pediatric transplantation, and administrative considerations including the transition to TTS as a section and the move to an online journal. The Membership committee with also be looking at how to enhance the value of IPTA membership, focusing on member renewal and retention, and recruitment of new members – especially junior members and allied health professionals.

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Outreach Committee

2017-2019 Initiatives

The Outreach committee is in the process of revising its mission, purpose and the application guidelines, processes and procedures - all of which will be made available to the IPTA membership when completed and approved by the IPTA Council. The committee has recently reviewed the status of the past projects and will provide a summary for the IPTA newsletter this year in addition to putting information on the IPTA website. The recent projects in Sri Lanka and Cape Town are in the process of being reviewed. In 2018, the committee will spearhead a call for a new round of applications following consolidation of all of the abovementioned initiatives. Stay tuned for more information!

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Publications and Communications Committee

2017-2019 Initiatives

The Publications committee is going to assume a central role in increasing the publications from IPTA members in Pediatric Transplantation using a number of different strategies. Some of these include iincreasing the number of publications coming from committee members, increasing the number of authors involved in IPTA-sponsored writing projects, expanding the scope of writing projects to include white papers and practice recommendations, and working with other IPTA committees on joint projects. The Publications committee plans to work on a Peer Mentoring program to help authors with backgrounds in languages other than English, to improve the quality of the language of their submissions. Finally, the Publications committee will take a leadership role in the quarterly IPTA newsletter, working with the other committees to provide content that is interesting and relevant to the IPTA membership.

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International Pediatric Transplant Association December 2016 Newsletter

IPTA PRESIDENT’S MESSAGE

Tonshoff 04Dear IPTA members, colleagues and friends,

The Executive Committee, the Council and the IPTA committees are pleased to provide you with the second Newsletter this year for an update of our Association's activities. We will give you a comprehensive update on the projects and initiatives of the Education Committee, Infectious Disease Committee, Publication Committee, and the newly founded Ethics Committee. We are delighted that 24 IPTA members recently volunteered for collaboration in these committees! It is a good way to involve the membership and to increase the interaction with the transplant community.

The upcoming 26th International Congress of the Transplantation Society (TTS) will be held in Hong Kong from August 18-23, 2016. There will be various IPTA activities during the congress such as an IPTA/TTS Pediatric Post Graduate Course on August 19, 2016 focusing on two major topics: “Listing children for solid organ transplantation and donor selection” and “Specific aspects of post-transplant care in children” and two scientific sessions organized by IPTA. Hopefully you will have the chance to join this important congress with our mother society TTS. Please stop by for a chat; all of your suggestions are welcome. Have a great summer!

Warm regards,

Burkhard Tönshoff

IPTA President

IPTA 2017: A CONGRESS OF COLLABORATIONS!
Anne I. Dipchand, Congress Chair

EIGHT MONTHS TO GO … and it will go by so quickly! Program planning is well underway and we are thrilled with the response and enthusiasm of our invited speakers! Look for a preliminary program to be online later in 2016.

Collaboration is an important part of the IPTA 2017 Congress. On the springboard of our partnership with TTS, we have actively pursued opportunities to partner with other transplant organizations. It is important that we all work together as a community to advance the science and practice of transplant medicine, especially the pediatric component through IPTA. The Barcelona Congress will showcase collaborative sessions between IPTA and the following organizations:

We are very excited about the opportunity to work together with these international transplant societies and believe that this will be the beginning of future partnerships allowing us to advance pediatric offerings moving forward. We continue to work with other organizations and hope to add to this list over the next few months.

Every society is as strong as its members, and the same can be said for IPTA. You will soon receive requests for nominations for the IPTA biennial awards. We look forward to your nominations of your colleagues around the world so that we can honor them for their dedication to pediatric transplantation. This year we will also announce the first IPTA Pioneer in Transplantation lecture and award to a well deserving pioneer in our field.

As you plan your trip to IPTA 2017, here is a recap of other things to look forward to: a vibrant Opening Ceremony on Saturday May 26th; scientific sessions that will include world renowned plenary and state-of-the art speakers; and the very popular parallel interactive workshop sessions with experts in the field. Experience the history of medicine in Spain at the Hospital San Pau during the congress social evening on Monday May 28th.

PEDIATRIC ORGAN TRANSPLANTATION SUMMER SCHOOL
ZAVIDOVO, RUSSIA

The IPTA Executive Committee and two former presidents of IPTA, Drs. Richard Fine and Richard Trompeter, had the opportunity to participate in the recent Pediatric Organ Transplantation Summer School, organized by Drs. Michael Kaabak and Nadeen Babenko of the Petrovsky Research Center of Surgery in Moscow. Two days of in depth discussions covering all aspects of pediatric kidney, heart and liver transplantation were presented to an audience of some 150 pediatric transplant specialists, mostly nephrologists and surgeons from all over Russia. The venue was near Tver, an hour north of Moscow. The talks were well received, with questions and discussion from the audience and among the speakers.

The pediatric kidney transplant program in Russia is the largest pediatric kidney transplant program in Russia, and performs some 30 transplants in children annually; it is the only program in Russia transplanting kidneys into small children under 5 years of age.

IMG 2685

Ron Shapiro, Anne Dipchand, Mignon McCulloch and Burkhard Tönshoff

EDUCATION COMMITTEE UPDATE
Chair: Christian Benden, Switzerland
Incoming Chair: Rohit Kohli, OH, USA

The Education Committee, an international group of pediatric transplant physicians/surgeons and allied health professionals, is responsible for expanding IPTA's educational activities. In 2016, the Education Committee has continued to expand the Society’s educational activities co-organizing the biennial IPTA Fellows Symposium on Pediatric Transplantation that took place at Mount Sinai in New York City in April this year with 30 fellows from around the world and an international faculty of experts in the field of pediatric transplantation. The IPTA Fellows Symposium provided updates in a broad spectrum of pediatric transplantation, but furthermore, an ideal environment for networking and mentoring. Once again the IPTA Fellows Symposium proved to be very popular amongst trainees, one of them stating that “… the whole meeting was phenomenal and it really helps give "newbies" like us perspective and help in trying to make our mark in the field…”

The Education Committee successfully submitted symposium proposals for the American Transplant Congress in May in Boston, MA, USA, and contributed to the educational content of a Joint IPTA/TTS Pediatric Post Graduate Course at the 26th International Congress of The Transplantation Society in August 2016 in Hong Kong. The Pediatric PG Course reviews listing criteria for children undergoing solid organ transplantation and donor selection, and provides insights on specific aspects of post-transplant care in children.

In the meantime, the Education Committee has already started to organize the educational content of the PG Course planned at the start of the upcoming 9th IPTA Congress to be held in Barcelona, Spain, in May 2017.

ID CARE COMMITTEE UPDATE
Upton Allen, ID CARE Committee Chair

The ID-CARE initiative was formed within IPTA with the idea that one of its main goals would be to serve as the focal point for ID initiatives and to link IPTA with other ID groups where appropriate. The focus is ID Clinical Care, Advocacy, Research and Education. The Committee seeks to engage IPTA members from all disciplines within pediatric organ stem cell transplantation.

The ID CARE Committee has been involved in several initiatives, some of which have been published in Pediatric Transplantation (Curriculum-related documents). In keeping with this approach, the group is currently working on a document that focuses on the evaluation and management of transplant candidates or recipients with recent active infections. A first draft of this document has been completed and submission to Pediatric Transplantation is expected in Fall 2016. The leads are Arnaud L’Huillier, Upton Allen and Michael Green.

The group has also identified other projects which are at varying stages of completion. Among these are the following:

  1. Status of use of live vaccines after pediatric solid organ. Klara Pofsay-Barbe is leading this initiative. In addition, a survey of current practices has been proposed.
  2. Pneumocystis prophylaxis strategies across transplant centers. This is being led by Mignon McCulloch and Marian Michaels.
  3. TB and Transplantation: A Pediatric Perspective. This initiative is led by Mignon McCulloch.
  4. Yearly Influenza update. This has been proposed as the first in the series of yearly influenza updates be led by Natasha Halasa. This will focus on what is new in influenza molecular epidemiology, antiviral drug resistance, vaccines, treatment and chemoprophylaxis with a focus on immunocompromised patients, notably transplant patients.
Over the upcoming months, the group looks forward to engaging representation from the HSCT group. Collaborations on selected documents or guidelines will also occur. These included, but are not limited to cytomegalovirus (CMV) or Post-transplant lymphoproliferative disorder (PTLD).

PEDIATRIC TRANSPLANTATION
UPDATE

PETR latest cover file

Wiley, publisher of Pediatric Transplantation has announced the acquisition of Atypon, one of the world’s leading scientific and scholarly information platform providers.

Wiley is very excited about joining up with our new colleagues at Atypon to bring you the best publishing technology in the industry. Atypon shares our values and focus on the researcher, and working with them is a natural extension of our commitment to providing flexibility to our partners and increasing digital engagement for readers.

Over the next 18 months, we’ll migrate from the platform supporting the Wiley Online Library to Atypon’s Literatum platform. This will bring a number of new benefits to users, including seamless access to content through authenticated article links, improved single-sign-on, editor highlights, article usage metrics, site-wide fully responsive mobile design, minimal-downtime releases, targeted content marketing, article recommendations and e-mail alerting, and more powerful search. This approach will allow us to more rapidly and flexibly respond to the changing needs of the communities we serve.

Wiley will join a diverse array of organizations currently using Atypon’s platform, including societies like the American Chemical Society, Massachusetts Medical Society (publishers of The New England Journal of Medicine), and the American Society of Civil Engineers; publishers such as Elsevier, Sage, and Taylor & Francis, and university presses.

This acquisition is part of our commitment at Wiley to supporting the advancement of scientific and scholarly research and helping authors to reach the widest audience possible and to create impact for their research, investing in the industry’s best technology experience and curating and protecting the version of record.

International Pediatric Transplant Association September 2016 Newsletter

IPTA PRESIDENT’S MESSAGE

Tonshoff 04Dear IPTA members, colleagues and friends,

The Executive Committee, the Council and the IPTA committees are pleased to provide you with the second Newsletter this year for an update of our Association's activities. We will give you a comprehensive update on the projects and initiatives of the Education Committee, Infectious Disease Committee, Publication Committee, and the newly founded Ethics Committee. We are delighted that 24 IPTA members recently volunteered for collaboration in these committees! It is a good way to involve the membership and to increase the interaction with the transplant community.

The upcoming 26th International Congress of the Transplantation Society (TTS) will be held in Hong Kong from August 18-23, 2016. There will be various IPTA activities during the congress such as an IPTA/TTS Pediatric Post Graduate Course on August 19, 2016 focusing on two major topics: “Listing children for solid organ transplantation and donor selection” and “Specific aspects of post-transplant care in children” and two scientific sessions organized by IPTA. Hopefully you will have the chance to join this important congress with our mother society TTS. Please stop by for a chat; all of your suggestions are welcome. Have a great summer!

Warm regards,

Burkhard Tönshoff

IPTA President

IPTA 2017: A CONGRESS OF COLLABORATIONS!
Anne I. Dipchand, Congress Chair

EIGHT MONTHS TO GO … and it will go by so quickly! Program planning is well underway and we are thrilled with the response and enthusiasm of our invited speakers! Look for a preliminary program to be online later in 2016.

Collaboration is an important part of the IPTA 2017 Congress. On the springboard of our partnership with TTS, we have actively pursued opportunities to partner with other transplant organizations. It is important that we all work together as a community to advance the science and practice of transplant medicine, especially the pediatric component through IPTA. The Barcelona Congress will showcase collaborative sessions between IPTA and the following organizations:

We are very excited about the opportunity to work together with these international transplant societies and believe that this will be the beginning of future partnerships allowing us to advance pediatric offerings moving forward. We continue to work with other organizations and hope to add to this list over the next few months.

Every society is as strong as its members, and the same can be said for IPTA. You will soon receive requests for nominations for the IPTA biennial awards. We look forward to your nominations of your colleagues around the world so that we can honor them for their dedication to pediatric transplantation. This year we will also announce the first IPTA Pioneer in Transplantation lecture and award to a well deserving pioneer in our field.

As you plan your trip to IPTA 2017, here is a recap of other things to look forward to: a vibrant Opening Ceremony on Saturday May 26th; scientific sessions that will include world renowned plenary and state-of-the art speakers; and the very popular parallel interactive workshop sessions with experts in the field. Experience the history of medicine in Spain at the Hospital San Pau during the congress social evening on Monday May 28th.

PEDIATRIC ORGAN TRANSPLANTATION SUMMER SCHOOL
ZAVIDOVO, RUSSIA

The IPTA Executive Committee and two former presidents of IPTA, Drs. Richard Fine and Richard Trompeter, had the opportunity to participate in the recent Pediatric Organ Transplantation Summer School, organized by Drs. Michael Kaabak and Nadeen Babenko of the Petrovsky Research Center of Surgery in Moscow. Two days of in depth discussions covering all aspects of pediatric kidney, heart and liver transplantation were presented to an audience of some 150 pediatric transplant specialists, mostly nephrologists and surgeons from all over Russia. The venue was near Tver, an hour north of Moscow. The talks were well received, with questions and discussion from the audience and among the speakers.

The pediatric kidney transplant program in Russia is the largest pediatric kidney transplant program in Russia, and performs some 30 transplants in children annually; it is the only program in Russia transplanting kidneys into small children under 5 years of age.

IMG 2685

Ron Shapiro, Anne Dipchand, Mignon McCulloch and Burkhard Tönshoff

EDUCATION COMMITTEE UPDATE
Chair: Christian Benden, Switzerland
Incoming Chair: Rohit Kohli, OH, USA

The Education Committee, an international group of pediatric transplant physicians/surgeons and allied health professionals, is responsible for expanding IPTA's educational activities. In 2016, the Education Committee has continued to expand the Society’s educational activities co-organizing the biennial IPTA Fellows Symposium on Pediatric Transplantation that took place at Mount Sinai in New York City in April this year with 30 fellows from around the world and an international faculty of experts in the field of pediatric transplantation. The IPTA Fellows Symposium provided updates in a broad spectrum of pediatric transplantation, but furthermore, an ideal environment for networking and mentoring. Once again the IPTA Fellows Symposium proved to be very popular amongst trainees, one of them stating that “… the whole meeting was phenomenal and it really helps give "newbies" like us perspective and help in trying to make our mark in the field…”

The Education Committee successfully submitted symposium proposals for the American Transplant Congress in May in Boston, MA, USA, and contributed to the educational content of a Joint IPTA/TTS Pediatric Post Graduate Course at the 26th International Congress of The Transplantation Society in August 2016 in Hong Kong. The Pediatric PG Course reviews listing criteria for children undergoing solid organ transplantation and donor selection, and provides insights on specific aspects of post-transplant care in children.

In the meantime, the Education Committee has already started to organize the educational content of the PG Course planned at the start of the upcoming 9th IPTA Congress to be held in Barcelona, Spain, in May 2017.

ID CARE COMMITTEE UPDATE
Upton Allen, ID CARE Committee Chair

The ID-CARE initiative was formed within IPTA with the idea that one of its main goals would be to serve as the focal point for ID initiatives and to link IPTA with other ID groups where appropriate. The focus is ID Clinical Care, Advocacy, Research and Education. The Committee seeks to engage IPTA members from all disciplines within pediatric organ stem cell transplantation.

The ID CARE Committee has been involved in several initiatives, some of which have been published in Pediatric Transplantation (Curriculum-related documents). In keeping with this approach, the group is currently working on a document that focuses on the evaluation and management of transplant candidates or recipients with recent active infections. A first draft of this document has been completed and submission to Pediatric Transplantation is expected in Fall 2016. The leads are Arnaud L’Huillier, Upton Allen and Michael Green.

The group has also identified other projects which are at varying stages of completion. Among these are the following:

  1. Status of use of live vaccines after pediatric solid organ. Klara Pofsay-Barbe is leading this initiative. In addition, a survey of current practices has been proposed.
  2. Pneumocystis prophylaxis strategies across transplant centers. This is being led by Mignon McCulloch and Marian Michaels.
  3. TB and Transplantation: A Pediatric Perspective. This initiative is led by Mignon McCulloch.
  4. Yearly Influenza update. This has been proposed as the first in the series of yearly influenza updates be led by Natasha Halasa. This will focus on what is new in influenza molecular epidemiology, antiviral drug resistance, vaccines, treatment and chemoprophylaxis with a focus on immunocompromised patients, notably transplant patients.
Over the upcoming months, the group looks forward to engaging representation from the HSCT group. Collaborations on selected documents or guidelines will also occur. These included, but are not limited to cytomegalovirus (CMV) or Post-transplant lymphoproliferative disorder (PTLD).

PEDIATRIC TRANSPLANTATION
UPDATE

PETR latest cover file

Wiley, publisher of Pediatric Transplantation has announced the acquisition of Atypon, one of the world’s leading scientific and scholarly information platform providers.

Wiley is very excited about joining up with our new colleagues at Atypon to bring you the best publishing technology in the industry. Atypon shares our values and focus on the researcher, and working with them is a natural extension of our commitment to providing flexibility to our partners and increasing digital engagement for readers.

Over the next 18 months, we’ll migrate from the platform supporting the Wiley Online Library to Atypon’s Literatum platform. This will bring a number of new benefits to users, including seamless access to content through authenticated article links, improved single-sign-on, editor highlights, article usage metrics, site-wide fully responsive mobile design, minimal-downtime releases, targeted content marketing, article recommendations and e-mail alerting, and more powerful search. This approach will allow us to more rapidly and flexibly respond to the changing needs of the communities we serve.

Wiley will join a diverse array of organizations currently using Atypon’s platform, including societies like the American Chemical Society, Massachusetts Medical Society (publishers of The New England Journal of Medicine), and the American Society of Civil Engineers; publishers such as Elsevier, Sage, and Taylor & Francis, and university presses.

This acquisition is part of our commitment at Wiley to supporting the advancement of scientific and scholarly research and helping authors to reach the widest audience possible and to create impact for their research, investing in the industry’s best technology experience and curating and protecting the version of record.