Help Shape the WHO Global Strategy for Donation and Transplantation
Final outreach to TTS leaders & community to review and provide input to the WHO Global Strategy for Donation and Transplantation
The public consultation on the World Health Organization (WHO) Global Strategy for Donation and Transplantation closes August 31, 2026.
TTS provided significant input into the early development of the Strategy, and this final consultation provides another important opportunity for the transplantation community to help shape this global framework. In addition to submitting comments directly to WHO, TTS invites you to contribute to TTS’s response in one or both of the following ways:
Submit written feedback to info@tts.org identifying the specific line(s) of the Strategy to which your comments relate by using the MS Word comment form (see link below) by Wednesday, August 26, 2026.
Join the TTS Open Forum on Friday, August 28 at 9:00 a.m. EDT to discuss the Strategy and suggestions for TTS feedback.
Announcement - TTS Business Meeting - Wednesday, September 23 - 12:00–12:30
Wednesday
23
SEPTEMBER
12:00–12:30
Darling Harbour
TTS 2026
TTS Business Meeting
Your Society. Your Business Meeting.
Join TTS leadership on Wednesday, September 23
for important Society updates and a look at the activities,
priorities and future direction of The Transplantation Society.
Make sure the TTS Business Meeting is part of
your Congress agenda.
Wednesday, September 23 12:00–12:30 •
Darling Harbour
Transplantation Journal Highlights
Transplantation Journal - Viewpoint
Quan Yao Ho, Singapore
Consultant Nephrologist, Transplant Physician Singapore General Hospital (SGH) SingHealth Duke-NUS Transplant Centre, Singapore Editorial Fellow
Can donor-derived regulatory dendritic cells (ddDCregs) be generated from liver allograft perfusate (LP)?
Viewpoint by editorial fellow by Quan Yao Ho on “Generation of Regulatory Dendritic Cells From Living Donor Liver Transplant Perfusates” Rosalia Busà, Alan F. Zahorchak, Camila Macedo, Suguru Mitsufuji, Diana M. Metes, Ester Badami, Beth D. Elinoff, Fadi G. Lakkis, Abhinav Humar, Pier Giulio Conaldi, Angus W. Thomson
Transplantation110(8):p e1657-e1668, August 2026. | DOI: 10.1097/TP.0000000000005787
Preclinical and early-phase clinical trials have demonstrated the safety and feasibility of ddDCregs in modulating immune responses in solid organ transplantation. However, these ddDCregs were generated from monocyte precursors in leukapheresis products, which may not be readily available, e.g. from deceased donors.
Busà et al. were able to generate ddDCregs from CD14+ precusors isolated from LP (LP-DCregs) taken during live donor liver procurement. The LP-DCregs generated were of high purity, phenotypically comparable to tolerogenic DCs from previous studies, and could suppress alloantigen-induced T cell proliferation in vitro.
These findings may represent the initial steps of utilising LP as an alternative source of DCregs for regulatory cell therapy in solid organ transplant immunomodulation.
Transplantation Journal - Social Media Content
Regulatory T Cells Allosensitized Under the Blockade of CD80/CD86-CD28 Costimulation Prolonged Islet Allograft Survival
Although CD80/CD86–CD28 costimulation is essential for the development and homeostasis of regulatory T cells (Tregs), a Treg-based cell product (referred to herein as induced T cells with suppressive functions or iTS) manufactured by allogeneic mixed lymphocyte reaction under costimulation blockade has demonstrated potential for minimizing immunosuppression and achieving operational tolerance in organ transplantation. However, the precise immunological mechanisms underlying Treg-induction therapy and its durable efficacy against donor alloantigens remain to be fully elucidated.
Small but Mighty Magnet: A Minimally Invasive Revolution in the Management of Ureterostenosis After Kidney Transplantation
Ureterostenosis affects 1%–8.3% of kidney transplant recipients, causing graft hydronephrosis, dysfunction, and potential loss. Traditional surgical repairs are invasive, technically challenging, and have a high recurrence risk. Magnetic compression anastomosis (MCA) presents a novel, minimally invasive alternative.
Persistent Financial Burdens and High Donor Satisfaction Among Living Liver Donors: A 24-y Single-center Study
Prior investigations on living donor hepatectomy have primarily focused on medical and psychosocial outcomes, with limited evaluation of financial implications. Financial support systems exist, but these are limited by strict income criteria, leaving some donors ineligible. This study sought to characterize donor-reported quality of life with a focus on postdonation financial burden.
The Transformative Journey of Vascularized Composite Allotransplantation: Advances, Challenges, and Future Directions
Vascularized composite allotransplantation (VCA) has emerged as a groundbreaking technique in reconstructive surgery, offering remarkable restoration of both function and aesthetics after severe tissue loss. However, despite its transformative clinical potential, widespread adoption remains limited because of the risk of rejection, the need for lifelong systemic immunosuppression and its associated risks, and donor-specific constraints unique to VCA, including morphological matching requirements and ethical and psychosocial considerations surrounding composite tissue donation. This review synthesizes findings from both basic research and clinical studies on VCA. We analyzed experimental studies using rodent and large-animal models and reviewed clinical outcomes in uterus, face, upper extremity, and abdominal wall transplants.
Welcome to the August 2026 edition of the ISODP Journal Watch.
In this edition, we have tried to draw out what we find interesting, question assumptions where warranted, and leave readers with something to think about. This reflects how we see research itself: not as a finished article, but as an ongoing act of critical reflection, where the value of any paper lies as much in the next hypothesis and research question it prompts as in the answers it offers. That is how the field keeps advancing, and how we all advance with it.
If a single thread runs through this edition's selection, it is one of the oldest and most consequential questions in our field: what do we mean by death, and how do we determine it? The papers gathered here approach that question from every direction, from donor biology and transplant outcomes, through law and international consensus, to the conversation that finally matters most: the one at the bedside with a grieving family.
We open at the circulatory end of the spectrum, with a study that challenges a piece of DCD dogma that has gone largely unquestioned for decades — that a shorter time to asystole is always better — and in doing so uncovers a more intriguing signal at the opposite end of the curve, where very rapid progression may identify a biologically distinct group of donors. From there we turn to the neurological determination of death, where the UK's first major revision to its Code of Practice in 17 years has prompted two complementary papers: one on what has changed and how to apply it, and another on how those criteria have acquired legal authority and where uncertainty still remains.
The collection then widens to practice and ethics. From Japan comes an unusually detailed look inside one of the world's most distinctive donation systems, with a lesson that unsettles easy assumptions: the hospitals doing more donation were not faster, but more multidisciplinary, more experienced, and apparently more successful. A systematic review asks why, two decades on, the same ethical concerns about DCD keep returning. Are these concerns barriers to overcome or enduring tensions that mature systems must learn to manage?
The final papers take that question to the international stage. Two Bucharest ESOT consensus papers ask how much of controlled DCD practice the world can actually agree on, and whether global consensus can do more than identify broad common ground between different donation systems.
We close where it all begins, and where all our efforts as donation professionals are put to the test. A study working with families rather than clinicians arrives at a quietly profound reframing: that families asked to accept a determination of death using neurological criteria may need less a transfer of knowledge than a transfer of trust, and that the most important tool remains the clinician who knows the words, uses them consistently, and has practised how to explain death.
As always, we hope these papers inform, provoke and occasionally unsettle. We welcome your thoughts and correspondence.
Aug. 13 - In this issue of Bone Marrow Transplantation, Kayser and colleagues report a large registry-based analysis comparing haploidentical and mismatched unrelated donor (MMUD) allogeneic hematopoietic stem cell transplantation (allo-HCT) with post-transplant cyclophosphamide (PTCy) in 711 adults with secondary acute myeloid leukemia (sAML) in first remission.
Aug. 13 - A new transplant technology being used in Montreal, Canada, could help doctors make more donated livers suitable for transplantation — potentially giving more patients access to life-saving organs.The technology uses a machine called Liver Assist to keep a donated liver functioning outside the body while doctors evaluate and treat it before transplantation.
Aug. 12 - UK scientists will grow miniature organs from NHS patient cells to improve medicine testing and reduce the number of animals used in drug development. The lab-grown tissues will be used to study how diseases differ between patients, helping researchers identify which treatments may work best according to the underlying cause of their condition.
Aug. 12 - Organs don't just grow in early life; they can change in response to physiological or environmental challenges in adulthood. Researchers have now identified an active role for the intestinal muscles in remodeling the gut after reproduction.
Aug. 14 - A decade after transplant, children who received marrow from a matched sibling showed improvement in working memory and processing speed on cognitive testing, but those who continued to receive frequent transfusions or hydroxyurea showed declines.