DOES RELATIONSHIP EXIST BETWEEN METABOLIC SYNDROME AND CORONARY ARTERY CALCIFICATION IN KIDNEY TRANSPLANT RECIPIENTS?

COMPLICATIONS - CARDIOVASCULAR

A. Adamowicz¹, P. Stró?ecki², Z. Serafin³, Z. W?odarczyk¹, J. Manitius², W. Lasek^3
1Dept Of Transplantology And Surgery, Collegium Medicum UMK, Bydgoszcz/POLAND, ²Dept Of Nephrology, Hypertension And Internal Diseases, Collegium Medicum UMK, Bydgoszcz/POLAND, ³Dept Of Radiology And Diagnostic Imaging, Collegium Medicum UMK, Bydgoszcz/POLAND

Body: Introduction: Metabolic syndorme (MS) is a common finding among kidney transplant recipients (KTR). Coronary artery calcification (CAC) is associated with increased mortality in patients with CKD. The relationship was found between MS components and CAC in general population. In recent study in KTR the prevalence of CAC increased with the number of MS components. The aim of our study was to investigate the relationship between MS and CAC in KTR. Patients and methods: The study group consisted of 104 KTR (31 females and 73 males), aged 49±12 years. All patients received graft from deceased donors. Total duration of renal replacement therapy (RRT) was 71±47 months, and kidney transplant follow-up 38±31 months. The diagnosis of MS was based on IDF criteria. CAC was determined with multi-detector row computed tomography as total calcium score (CS) and calcium mass (CM). Systolic and diastolic blood pressure (SBP, DBP) were measured. Fasting blood was sampled for serum lipids, glucose, high-sensitive C-reactive protein (hs-CRP) and serum creatinine. Glomerular filtration rate was calculated with abbreviated MDRD equation (eGFR). Results are expressed as mean±SD Results: Criteria of MS were met in 42 KTR (40%). CAC was found in 72 patients (69%). Patients without MS and patients with MS were compared.

Parameter	MS(-)	MS(+)	P
CAC (+)	40 (65%)	32 (76%)	NS
CS	373 ± 614	762 ± 1134	NS
CM (mg)	63 ± 105	127 ± 191	NS
Age	46 ± 12	53 ± 11	0,002
Gender (male)	46(74%)	27(64%)	NS
SBP (mmHg)	133 ± 19	135 ± 16	NS
DBP (mmHg)	83 ± 12	82 ± 11	NS
Waist (cm)	84 ± 12	98 ± 10	< 0,001
BMI (kg/m2)	23,8 ± 3,9	27,7 ± 3,7	< 0,001
TG (mg/dl)	135 ± 57	206 ± 91	< 0,001
Cholesterol (mg/dl)	201 ± 38	224 ± 59	< 0,05
LDL-cholesterol (mg/dl)	113 ± 30	121 ± 37	NS
HDL-cholesterol (mg/dl)	61 ± 14	60 ± 17	NS
hs-CRP (mg/l)	2,4 ± 3,2	3,3 ± 3,1	< 0,05
eGFR (ml/min/1,73m2)	58 ± 17	51 ± 17	NS

Significant positive correlation was found between number of MS components and CS (r=0,25; p=0,01) and CM (r=0,26, p=0,007) in the study population. Conclusions: The prevalence of coronary artery calcification in kidney transplant recipients is very high. The presence of coronary artery calcification in kidney transplant recipients is associated with classic risk factors for atherosclerosis but not with metabolic syndrome as a clinical phenomenon.

Disclosure: All authors have declared no conflicts of interest.