INTERNATIONAL TRENDS IN ORGAN DONATION

N. Techawathanawanna¹, R. Kunprakan¹, P. Lertsithichai², K. Pipatpannawong¹, N. Naitook¹, V. Mavichak¹, S. Jirasiritham^2
1Praram 9 Hospital, Kidney Transplantation Institute, Bangkok/THAILAND, ²Surgery, Ramathibodi Hospital, Bangkok/THAILAND

Body: Introduction Long-term outcomes of kidney transplantation using kidneys from deceased donors with acute kidney injury and other non-standard donors are not well described. Methods We reviewed our database of cadaveric kidney transplants from January 1997 through December 2009, comparing the outcomes of transplantation of kidneys from donors with acute kidney injury (with normal baseline renal function, AKI group, 28 cases) with standard criteria donor kidneys (SCD group, 33 cases), expanded criteria donor kidneys (ECD group, 10 cases), and kidneys from donors with renal impairment (with unknown baseline renal function, RI group, 14 cases). Baseline characteristics of donors and recipients were correlated with short-term and long-term graft function. Results One-year and five-year graft survival were 96.4% and 96.4% in AKI group, 100% and 92.9% in SCD group, 80.0% and 57.1% in ECD group, and 92.9% and 92.9% in the RI group. Mean five-year estimated glomerular filtration rates, calculated by CKD-EPI formula, were 55.2, 51.4, 37.5, and 58.2 ml/minute in AKI, SCD, ECD and RI groups, respectively. Risk factors for decreased glomerular filtration rate included the ECD group, and age of the donor. Risk factors for decreased graft survival included the ECD group and the number of hemodialysis sessions required within the first few weeks after transplantation. Conclusion Kidneys from deceased donors with acute kidney injury can potentially be used for transplantation with comparable long-term outcomes to standard criteria donors.

Disclosure: All authors have declared no conflicts of interest.