2011 - BSS 2011 Symposium


Plenary Session 3: Emerging Issues in Transplantation: Composite Tissue Transplantation and Immunosenescence

7.2 - Impact of Age on the Immune Response after Organ Transplantation

Presenter: Christian, Denecke, innsbruck, Austria
Authors: Christian Denecke



The Impact of Age on the Immune Response after Organ Transplantation

Ageing is an emerging topic in organ transplantation. An increasing number of marginal grafts from older donors are being utilized for transplantation. Older organs are frequently allocated to elderly recipients who represent the fastest growing patient population on the waiting list.

Donor age impairs the ability for tissue repair and may render older organs more immunogenic. In contrast, ageing of the immune system („immunosenescence“) has a significant influence on the T-cell responses, thereby decreasing the risk of acute rejection. Investigating the effects of advanced donor and recipient age on the immune response after transplantation seems critical in order to avoid under – or overimmunosuppression. Although less well understood, immunosenescence and organ age specific aspects of injury and repair may likely affect tolerance protocols.

The influence of ageing on both graft quality and the post-transplant immune response will become increasingly important for improving long-term graft and patient outcome and establishing clinical tolerance protocols.


You must be logged in to view recordings

Important Disclaimer

By viewing the material on this site you understand and accept that:

  1. The opinions and statements expressed on this site reflect the views of the author or authors and do not necessarily reflect those of The Transplantation Society and/or its Sections.
  2. The hosting of material on The Transplantation Society site does not signify endorsement of this material by The Transplantation Society and/or its Sections.
  3. The material is solely for educational purposes for qualified health care professionals.
  4. The Transplantation Society and/or its Sections are not liable for any decision made or action taken based on the information contained in the material on this site.
  5. The information cannot be used as a substitute for professional care.
  6. The information does not represent a standard of care.
  7. No physician-patient relationship is being established.

Our Corporate Sponsors

TTS gratefully acknowledges the Corporate Partners whose generous support makes the work of the Society possible:

  • astellas
  • roche
  • sanofi