2010 - Transplantomics and Biomarkers in Transplantation
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NOVEL APPLICATIONS FOR GENOMIC TECHNOLOGIES IN ORG
1.5 - EXPLORING GENOMIC MEDICINE USING TRANSLATIONAL BIOINFORMATICS
Presenter: Atul, Butte, Stanford, USA
Authors: Atul Butte
EXPLORING GENOMIC MEDICINE USING TRANSLATIONAL BIOINFORMATICS
Atul Butte, Assistant Professor, Medicine, Stanford Medical Informatics, Stanford University, Stanford, CA, USA
Atul Butte, Assistant Professor, Medicine, Stanford Medical Informatics, Stanford University, Stanford, CA, USA
Learning Objectives:
1. How publicly-available molecular measurements can be used to probe disease mechanisms.
2. How RNA is the new proteomics.
3. How bioinformatics has moved from a service-provider role to a science role.
With the end of the United States NIH budget doubling and completion of the Human Genome Project, there is a need to translate genome-era discoveries into clinical utility. The difficulties in making bench-to-bedside translations have been described: comprehensive molecular studies on patients are expensive, and hospitals are not phenotypers. The nascent field of translational bioinformatics may help. I will show how we build and apply tools that convert the billions of points of molecular, clinical, and epidemiological data measured by biomedical investigators and clinicians over the past decade into insights into diagnostic and therapeutic potential. I will highlight how using publicly-available molecular data enables the discovery of new gene variants and biomarkers for diseases like transplantation rejection and diabetes, suggests novel roles for drugs in the treatment of disease, and for the first time allows us to probe the inner commonality across disease.
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