P-264 Poster of distinction

Evaluation of segmental pancreatic function using 11C-methionine positron emission tomography for safe living donor operation of pancreas transplantation

K. Otsuki¹, T. Kenmochi¹, K. Saigo¹, M. Maruyama¹, N. Akutsu¹, C. Iwashita¹, T. Ito¹, T. Asano¹, K. Yoshikawa², H. Matsubara^3
1 National Chiba-East Hospital, Chiba, Japan; ² National Institute of Radological Sciences, Chiba, Japan; ³ Chiba university, Chiba, Japan

For the safe of donor operation of living pancreas transplantation, the function of residual pancreas head was evaluated using 11C-methionine positron emission tomography (PET) in thirteen living donors before and after distal pancreatectomy. After 6 hours fasting, 11C-methionin (370 to 740MBq) was intravenously administered into the patients. PET was scanned at 30 minutes after injection, 11C-methionine PET uptakes of pancreas head was expressed as standardized uptake value (SUV). The SUVs of the pancreas head were compared between before and after surgery. The SUVs of pancreas head in living donors (n=13) before and after distal pancreatectomy were17.3+/-2.5 and 17.4+/-4.9, respectively, demonstrating no significant difference. However, the changes in SUVs of the residual pancreas head showed three patterns after surgery. The SUVs elevated in 3 donors (23%), and maintained in 5 donors (38%). However, 5 donors (38%) showed the slight decrease of SUVs after sugery. Although diabetes mellitus has not been developed in all thirteen donors, the function of the pancreatic head was slightly decreased in about 40% of the donors a fter distal pancreatectomy. To avoid postoperative diabetes mellitus for a prolonged period, the donors who showed the decreased SUV after surgery should be strictly followed up. 11C-methionine PET may become a potent modality to evaluate segmental pancreatic function for a safe living donor operation of pancreas transplantation.

P-264 Poster of distinction

Evaluation of segmental pancreatic function using 11C-methionine positron emission tomography for safe living donor operation of pancreas transplantation

K. Otsuki¹, T. Kenmochi¹, K. Saigo¹, M. Maruyama¹, N. Akutsu¹, C. Iwashita¹, T. Ito¹, T. Asano¹, K. Yoshikawa², H. Matsubara^3
1 National Chiba-East Hospital, Chiba, Japan; ² National Institute of Radological Sciences, Chiba, Japan; ³ Chiba university, Chiba, Japan

For the safe of donor operation of living pancreas transplantation, the function of residual pancreas head was evaluated using 11C-methionine positron emission tomography (PET) in thirteen living donors before and after distal pancreatectomy. After 6 hours fasting, 11C-methionin (370 to 740MBq) was intravenously administered into the patients. PET was scanned at 30 minutes after injection, 11C-methionine PET uptakes of pancreas head was expressed as standardized uptake value (SUV). The SUVs of the pancreas head were compared between before and after surgery. The SUVs of pancreas head in living donors (n=13) before and after distal pancreatectomy were17.3+/-2.5 and 17.4+/-4.9, respectively, demonstrating no significant difference. However, the changes in SUVs of the residual pancreas head showed three patterns after surgery. The SUVs elevated in 3 donors (23%), and maintained in 5 donors (38%). However, 5 donors (38%) showed the slight decrease of SUVs after sugery. Although diabetes mellitus has not been developed in all thirteen donors, the function of the pancreatic head was slightly decreased in about 40% of the donors a fter distal pancreatectomy. To avoid postoperative diabetes mellitus for a prolonged period, the donors who showed the decreased SUV after surgery should be strictly followed up. 11C-methionine PET may become a potent modality to evaluate segmental pancreatic function for a safe living donor operation of pancreas transplantation.