IPTA September 2017 Newsletter

ipta newsletter

IPTA 2017 Congress | Ethics Case Study 1 | Ethics Case Study 2 | Literary Highlights | Ethics Committee | Education Committee | Publications & Communications Committees | Membership Committee | Allied Health Professional Committee | Outreach Committee | ID Committee

IPTA 2017 Congress

ipta2017

IPTA Council – Barcelona, Spain

The 9th Congress of the International Pediatric Transplant Association (IPTA) took place in Barcelona, Spain, from May 27-30, 2017 and was a great success both in terms of its excellent attendance and its scientific quality. Topics being addressed were updates and new data from ongoing pediatric transplant clinical trials (CTOTC), long-term complications following transplantation, standards for surveillance and treatment of infections in transplantation, perspectives in immune tolerance, up-to-date data from important registries, new and emerging immunosuppressive agents, ethical dilemmas in pediatric transplantation, devices used to support transplantation, issues in noncompliance and transfer of care, just to name a few.

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Ethical Case Studies

IPTA is pleased to introduce Case Studies dealing with key ethical issues in our quarterly newsletters to spark awareness, education and discussion. These will be spearheaded by the IPTA Ethics committee.

Case Study 1

Introduction

An eight-year-old girl with end-stage kidney disease secondary to Finnish type congenital nephrotic syndrome initially managed with daily albumin infusions requiring peritoneal dialysis from nine months of age followed by bilateral retroperitoneal nephrectomies at ten months of age. In her first two years of life, she had numerous treatment-related problems including multiple episodes of sepsis, requiring changes of central venous catheters; a chronically leaking gastrostomy (which eventually was removed) and severe gastro-oesophageal reflux disease, hypothyroidism, renal osteodystrophy and hypertension secondary to fluid overload. Following several episodes of severe peritonitis, including MRSA peritonitis, her peritoneal dialysis catheter was removed and subsequently an abdominal collection was drained. Haemodialysis was then commenced, but venous access proved to be difficult and became increasingly so over the forthcoming months.

A venogram revealed many occluded and stenosed veins; the thromboses in the superior vena cava and subclavian veins were identified as compromising catheter patency. At 19 months, she was admitted urgently to hospital with physical signs of acute sepsis (fever, tachycardia) associated with marked abdominal distension and tenderness. She failed to respond to standard antibiotic therapy and was found to have vegetation on the tricuspid valve within the right ventricle, suggestive of infective endocarditis, but without evidence of pulmonary emboli. She was treated with six weeks of intravenous antibiotics, and a permanent haemodialysis catheter was inserted. At this stage, our patient had suffered episodes of severe MRSA peritonitis associated with staphylococcal bacterial endocarditis, necessitating the removal of her peritoneal catheter; peritoneal dialysis was no longer an option. Haemodialysis was also problematic because of extreme difficulty in vascular access; it also became apparent that a vascular graft for haemodialysis would not be successful.

Unfortunately, there were no transplant options as she had been on call for over a year for a deceased donor and there was no living donor as her mother could not donate for medical reasons and her father, although a suitable match, stated he was unable to donate.

What medical care options exist for this patient?
What are the ethical considerations?

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Case Study 2

A 3 year old girl was diagnosed with nephrotic syndrome secondary to FSGS. She was initially treated with steroids and Cytoxan later converted to cyclosporine A. Despite treatment she slowly deteriorated into ESRD and started dialysis. At 10 years of age, she underwent a deceased donor kidney transplantation and was managed with triple immunosuppressive protocol (CyA, MMF and steroids) without pre-transplant plasmapheresis (PP).

At the 14th post op day with creatinine levels dropping to 1.0mg/dL she developed proteinuria of 17g//24hr. and was placed on PP sessions 3 times/ week followed by Rituximab (single dose of 375mg/m2). The following months despite aggressive continuous sessions of PP maintaining her protein urine level < 10g/day she developed hypoalbuminemia (albumin levels 2.2g/dl) associated with severe leg edema, skin infection and convulsive disorder secondary to PRESS. At six months after transplant her mother requested to discontinue immunosuppressive treatment and she returned to dialysis.

Six years later she was fed up with dialysis and asked to be listed for a second transplant.

At this stage would you consider a second transplant using one of the parents who was a match donor knowing that this scenario might be associated with a high risk of recurrence?

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Literary Highlights

With each newsletter, we plan to have an IPTA member highlight important recent publications in an area of general interest. Since all our members have access to our journal PEDIATRIC TRANSPLANTATION, this feature will highlight reports, from other journals, which may not be readily available to all our members. As with this inaugural edition, reports of adult data that may have relevance to our members may also be included. This newsletters’ literary highlights come from Sharon Bartosh, M.D., Chief, Pediatric Nephrology, American Family Children’s Hospital, University of Wisconsin.

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IPTA Committees 2017-2019

Much of the work of IPTA is can only be done through the contributions of our committees. We would like to introduce you to the IPTA committees for 2017-2019 and share their current initiatives.

Allied Health Professional (AHP) Committee

2017-2019 Initiatives

The AHP committee is in the process of carrying out a survey to describe the demographics and interests of transplant allied health professionals. The goal is to determine how the allied health committee can encourage and increase IPTA membership, as well as foster a greater involvement in allied health activities and committee work within the organization. The committee will revise and expand the Allied Health Professional page on the IPTA website to include a mission statement, a description of the AH community in transplant and their specific roles in caring for pediatric transplant patients, committee initiatives, membership benefits, quotes from members and how to become a member. The committee also plans to explore a link for networking and the ability to post questions to other AH members. The committee plans to develop an article for publication in Pediatric Transplantation on a contemporary topic that is relevant to the AHP community in addition to participating in review of the UNOS parent manual.

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Education Committee

2017-2019 Initiatives

The Education committee has already participated in the IPTA review of the UNOS parent material and is in the process of a survey related to the Postgraduate Course of the IPTA 9th Congress in order to inform further course development. The Education committee will be developing the curriculum for the IPTA Fellows meeting in November 2018 and the renamed postgraduate course “Foundations in Transplantation” for the IPTA 10th Congress in Vancouver in 2019. Other exciting initiatives will be forthcoming this Fall.

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Ethics Committee

2017-2019 Initiatives

The Ethics committee is the newest IPTA committee that has been formed to address the increasing ethical awareness in pediatric solid organ transplantation. As they develop their initiatives as a new committee, the group plans to raise awareness and educate by contributing cases to the IPTA newsletter (see this issue of the newsletter for their first contribution). In addition, to build upon a recent TTS initiative, they will be editing the recent TTS Ethics Survey for pediatrics with a goal to circulate it in early 2018 and to use the information gathered as a foundation for further initiatives moving forward.

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Infectious Disease Committee

2017-2019 Initiatives

The ID committee has a number of active initiatives involving assessing current practice and developing consensus recommendations for publication in Pediatric Transplantation including 1) evaluation and approach to the presence of active infection in the potential pediatric transplant recipient, 2) status of the use of live vaccines after pediatric solid organ transplantation, and 3) pneumocystis prophylaxis strategies, in addition to a yearly Influenza Update. The ID Committee is proposing to develop a commentary to the TTS CMV Guidelines (currently in progress) specific to the pediatric perspective. This would highlight changes to both the overall document as well as to the pediatric section and its recommendations. In addition, the Committee hopes that the proposed commentary could identify ongoing pediatric specific gaps in the data with a goal of hoping to target future. Looking ahead, the ID committee is exploring the development of PTLD practice recommendations potentially including diagnosis, management and prevention. These are just some of the exciting initiatives coming out of the ID committee.

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Membership Committee

2017-2019 Initiatives

The Membership Committee will be exploring a new dues structure for IPTA which is long overdue. This will take into consideration many different factors including our diverse membership of an international nature, the need to foster collaboration at all levels of pediatric transplantation, the need to develop junior people to pursue pediatric transplantation, and administrative considerations including the transition to TTS as a section and the move to an online journal. The Membership committee with also be looking at how to enhance the value of IPTA membership, focusing on member renewal and retention, and recruitment of new members – especially junior members and allied health professionals.

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Outreach Committee

2017-2019 Initiatives

The Outreach committee is in the process of revising its mission, purpose and the application guidelines, processes and procedures - all of which will be made available to the IPTA membership when completed and approved by the IPTA Council. The committee has recently reviewed the status of the past projects and will provide a summary for the IPTA newsletter this year in addition to putting information on the IPTA website. The recent projects in Sri Lanka and Cape Town are in the process of being reviewed. In 2018, the committee will spearhead a call for a new round of applications following consolidation of all of the abovementioned initiatives. Stay tuned for more information!

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Publications and Communications Committee

2017-2019 Initiatives

The Publications committee is going to assume a central role in increasing the publications from IPTA members in Pediatric Transplantation using a number of different strategies. Some of these include iincreasing the number of publications coming from committee members, increasing the number of authors involved in IPTA-sponsored writing projects, expanding the scope of writing projects to include white papers and practice recommendations, and working with other IPTA committees on joint projects. The Publications committee plans to work on a Peer Mentoring program to help authors with backgrounds in languages other than English, to improve the quality of the language of their submissions. Finally, the Publications committee will take a leadership role in the quarterly IPTA newsletter, working with the other committees to provide content that is interesting and relevant to the IPTA membership.

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International Pediatric Transplant Association December 2016 Newsletter

IPTA PRESIDENT’S MESSAGE

Tonshoff 04Dear IPTA members, colleagues and friends,

The Executive Committee, the Council and the IPTA committees are pleased to provide you with the second Newsletter this year for an update of our Association's activities. We will give you a comprehensive update on the projects and initiatives of the Education Committee, Infectious Disease Committee, Publication Committee, and the newly founded Ethics Committee. We are delighted that 24 IPTA members recently volunteered for collaboration in these committees! It is a good way to involve the membership and to increase the interaction with the transplant community.

The upcoming 26th International Congress of the Transplantation Society (TTS) will be held in Hong Kong from August 18-23, 2016. There will be various IPTA activities during the congress such as an IPTA/TTS Pediatric Post Graduate Course on August 19, 2016 focusing on two major topics: “Listing children for solid organ transplantation and donor selection” and “Specific aspects of post-transplant care in children” and two scientific sessions organized by IPTA. Hopefully you will have the chance to join this important congress with our mother society TTS. Please stop by for a chat; all of your suggestions are welcome. Have a great summer!

Warm regards,

Burkhard Tönshoff

IPTA President

IPTA 2017: A CONGRESS OF COLLABORATIONS!
Anne I. Dipchand, Congress Chair

EIGHT MONTHS TO GO … and it will go by so quickly! Program planning is well underway and we are thrilled with the response and enthusiasm of our invited speakers! Look for a preliminary program to be online later in 2016.

Collaboration is an important part of the IPTA 2017 Congress. On the springboard of our partnership with TTS, we have actively pursued opportunities to partner with other transplant organizations. It is important that we all work together as a community to advance the science and practice of transplant medicine, especially the pediatric component through IPTA. The Barcelona Congress will showcase collaborative sessions between IPTA and the following organizations:

We are very excited about the opportunity to work together with these international transplant societies and believe that this will be the beginning of future partnerships allowing us to advance pediatric offerings moving forward. We continue to work with other organizations and hope to add to this list over the next few months.

Every society is as strong as its members, and the same can be said for IPTA. You will soon receive requests for nominations for the IPTA biennial awards. We look forward to your nominations of your colleagues around the world so that we can honor them for their dedication to pediatric transplantation. This year we will also announce the first IPTA Pioneer in Transplantation lecture and award to a well deserving pioneer in our field.

As you plan your trip to IPTA 2017, here is a recap of other things to look forward to: a vibrant Opening Ceremony on Saturday May 26th; scientific sessions that will include world renowned plenary and state-of-the art speakers; and the very popular parallel interactive workshop sessions with experts in the field. Experience the history of medicine in Spain at the Hospital San Pau during the congress social evening on Monday May 28th.

PEDIATRIC ORGAN TRANSPLANTATION SUMMER SCHOOL
ZAVIDOVO, RUSSIA

The IPTA Executive Committee and two former presidents of IPTA, Drs. Richard Fine and Richard Trompeter, had the opportunity to participate in the recent Pediatric Organ Transplantation Summer School, organized by Drs. Michael Kaabak and Nadeen Babenko of the Petrovsky Research Center of Surgery in Moscow. Two days of in depth discussions covering all aspects of pediatric kidney, heart and liver transplantation were presented to an audience of some 150 pediatric transplant specialists, mostly nephrologists and surgeons from all over Russia. The venue was near Tver, an hour north of Moscow. The talks were well received, with questions and discussion from the audience and among the speakers.

The pediatric kidney transplant program in Russia is the largest pediatric kidney transplant program in Russia, and performs some 30 transplants in children annually; it is the only program in Russia transplanting kidneys into small children under 5 years of age.

IMG 2685

Ron Shapiro, Anne Dipchand, Mignon McCulloch and Burkhard Tönshoff

EDUCATION COMMITTEE UPDATE
Chair: Christian Benden, Switzerland
Incoming Chair: Rohit Kohli, OH, USA

The Education Committee, an international group of pediatric transplant physicians/surgeons and allied health professionals, is responsible for expanding IPTA's educational activities. In 2016, the Education Committee has continued to expand the Society’s educational activities co-organizing the biennial IPTA Fellows Symposium on Pediatric Transplantation that took place at Mount Sinai in New York City in April this year with 30 fellows from around the world and an international faculty of experts in the field of pediatric transplantation. The IPTA Fellows Symposium provided updates in a broad spectrum of pediatric transplantation, but furthermore, an ideal environment for networking and mentoring. Once again the IPTA Fellows Symposium proved to be very popular amongst trainees, one of them stating that “… the whole meeting was phenomenal and it really helps give "newbies" like us perspective and help in trying to make our mark in the field…”

The Education Committee successfully submitted symposium proposals for the American Transplant Congress in May in Boston, MA, USA, and contributed to the educational content of a Joint IPTA/TTS Pediatric Post Graduate Course at the 26th International Congress of The Transplantation Society in August 2016 in Hong Kong. The Pediatric PG Course reviews listing criteria for children undergoing solid organ transplantation and donor selection, and provides insights on specific aspects of post-transplant care in children.

In the meantime, the Education Committee has already started to organize the educational content of the PG Course planned at the start of the upcoming 9th IPTA Congress to be held in Barcelona, Spain, in May 2017.

ID CARE COMMITTEE UPDATE
Upton Allen, ID CARE Committee Chair

The ID-CARE initiative was formed within IPTA with the idea that one of its main goals would be to serve as the focal point for ID initiatives and to link IPTA with other ID groups where appropriate. The focus is ID Clinical Care, Advocacy, Research and Education. The Committee seeks to engage IPTA members from all disciplines within pediatric organ stem cell transplantation.

The ID CARE Committee has been involved in several initiatives, some of which have been published in Pediatric Transplantation (Curriculum-related documents). In keeping with this approach, the group is currently working on a document that focuses on the evaluation and management of transplant candidates or recipients with recent active infections. A first draft of this document has been completed and submission to Pediatric Transplantation is expected in Fall 2016. The leads are Arnaud L’Huillier, Upton Allen and Michael Green.

The group has also identified other projects which are at varying stages of completion. Among these are the following:

  1. Status of use of live vaccines after pediatric solid organ. Klara Pofsay-Barbe is leading this initiative. In addition, a survey of current practices has been proposed.
  2. Pneumocystis prophylaxis strategies across transplant centers. This is being led by Mignon McCulloch and Marian Michaels.
  3. TB and Transplantation: A Pediatric Perspective. This initiative is led by Mignon McCulloch.
  4. Yearly Influenza update. This has been proposed as the first in the series of yearly influenza updates be led by Natasha Halasa. This will focus on what is new in influenza molecular epidemiology, antiviral drug resistance, vaccines, treatment and chemoprophylaxis with a focus on immunocompromised patients, notably transplant patients.
Over the upcoming months, the group looks forward to engaging representation from the HSCT group. Collaborations on selected documents or guidelines will also occur. These included, but are not limited to cytomegalovirus (CMV) or Post-transplant lymphoproliferative disorder (PTLD).

PEDIATRIC TRANSPLANTATION
UPDATE

PETR latest cover file

Wiley, publisher of Pediatric Transplantation has announced the acquisition of Atypon, one of the world’s leading scientific and scholarly information platform providers.

Wiley is very excited about joining up with our new colleagues at Atypon to bring you the best publishing technology in the industry. Atypon shares our values and focus on the researcher, and working with them is a natural extension of our commitment to providing flexibility to our partners and increasing digital engagement for readers.

Over the next 18 months, we’ll migrate from the platform supporting the Wiley Online Library to Atypon’s Literatum platform. This will bring a number of new benefits to users, including seamless access to content through authenticated article links, improved single-sign-on, editor highlights, article usage metrics, site-wide fully responsive mobile design, minimal-downtime releases, targeted content marketing, article recommendations and e-mail alerting, and more powerful search. This approach will allow us to more rapidly and flexibly respond to the changing needs of the communities we serve.

Wiley will join a diverse array of organizations currently using Atypon’s platform, including societies like the American Chemical Society, Massachusetts Medical Society (publishers of The New England Journal of Medicine), and the American Society of Civil Engineers; publishers such as Elsevier, Sage, and Taylor & Francis, and university presses.

This acquisition is part of our commitment at Wiley to supporting the advancement of scientific and scholarly research and helping authors to reach the widest audience possible and to create impact for their research, investing in the industry’s best technology experience and curating and protecting the version of record.

International Pediatric Transplant Association September 2016 Newsletter

IPTA PRESIDENT’S MESSAGE

Tonshoff 04Dear IPTA members, colleagues and friends,

The Executive Committee, the Council and the IPTA committees are pleased to provide you with the second Newsletter this year for an update of our Association's activities. We will give you a comprehensive update on the projects and initiatives of the Education Committee, Infectious Disease Committee, Publication Committee, and the newly founded Ethics Committee. We are delighted that 24 IPTA members recently volunteered for collaboration in these committees! It is a good way to involve the membership and to increase the interaction with the transplant community.

The upcoming 26th International Congress of the Transplantation Society (TTS) will be held in Hong Kong from August 18-23, 2016. There will be various IPTA activities during the congress such as an IPTA/TTS Pediatric Post Graduate Course on August 19, 2016 focusing on two major topics: “Listing children for solid organ transplantation and donor selection” and “Specific aspects of post-transplant care in children” and two scientific sessions organized by IPTA. Hopefully you will have the chance to join this important congress with our mother society TTS. Please stop by for a chat; all of your suggestions are welcome. Have a great summer!

Warm regards,

Burkhard Tönshoff

IPTA President

IPTA 2017: A CONGRESS OF COLLABORATIONS!
Anne I. Dipchand, Congress Chair

EIGHT MONTHS TO GO … and it will go by so quickly! Program planning is well underway and we are thrilled with the response and enthusiasm of our invited speakers! Look for a preliminary program to be online later in 2016.

Collaboration is an important part of the IPTA 2017 Congress. On the springboard of our partnership with TTS, we have actively pursued opportunities to partner with other transplant organizations. It is important that we all work together as a community to advance the science and practice of transplant medicine, especially the pediatric component through IPTA. The Barcelona Congress will showcase collaborative sessions between IPTA and the following organizations:

We are very excited about the opportunity to work together with these international transplant societies and believe that this will be the beginning of future partnerships allowing us to advance pediatric offerings moving forward. We continue to work with other organizations and hope to add to this list over the next few months.

Every society is as strong as its members, and the same can be said for IPTA. You will soon receive requests for nominations for the IPTA biennial awards. We look forward to your nominations of your colleagues around the world so that we can honor them for their dedication to pediatric transplantation. This year we will also announce the first IPTA Pioneer in Transplantation lecture and award to a well deserving pioneer in our field.

As you plan your trip to IPTA 2017, here is a recap of other things to look forward to: a vibrant Opening Ceremony on Saturday May 26th; scientific sessions that will include world renowned plenary and state-of-the art speakers; and the very popular parallel interactive workshop sessions with experts in the field. Experience the history of medicine in Spain at the Hospital San Pau during the congress social evening on Monday May 28th.

PEDIATRIC ORGAN TRANSPLANTATION SUMMER SCHOOL
ZAVIDOVO, RUSSIA

The IPTA Executive Committee and two former presidents of IPTA, Drs. Richard Fine and Richard Trompeter, had the opportunity to participate in the recent Pediatric Organ Transplantation Summer School, organized by Drs. Michael Kaabak and Nadeen Babenko of the Petrovsky Research Center of Surgery in Moscow. Two days of in depth discussions covering all aspects of pediatric kidney, heart and liver transplantation were presented to an audience of some 150 pediatric transplant specialists, mostly nephrologists and surgeons from all over Russia. The venue was near Tver, an hour north of Moscow. The talks were well received, with questions and discussion from the audience and among the speakers.

The pediatric kidney transplant program in Russia is the largest pediatric kidney transplant program in Russia, and performs some 30 transplants in children annually; it is the only program in Russia transplanting kidneys into small children under 5 years of age.

IMG 2685

Ron Shapiro, Anne Dipchand, Mignon McCulloch and Burkhard Tönshoff

EDUCATION COMMITTEE UPDATE
Chair: Christian Benden, Switzerland
Incoming Chair: Rohit Kohli, OH, USA

The Education Committee, an international group of pediatric transplant physicians/surgeons and allied health professionals, is responsible for expanding IPTA's educational activities. In 2016, the Education Committee has continued to expand the Society’s educational activities co-organizing the biennial IPTA Fellows Symposium on Pediatric Transplantation that took place at Mount Sinai in New York City in April this year with 30 fellows from around the world and an international faculty of experts in the field of pediatric transplantation. The IPTA Fellows Symposium provided updates in a broad spectrum of pediatric transplantation, but furthermore, an ideal environment for networking and mentoring. Once again the IPTA Fellows Symposium proved to be very popular amongst trainees, one of them stating that “… the whole meeting was phenomenal and it really helps give "newbies" like us perspective and help in trying to make our mark in the field…”

The Education Committee successfully submitted symposium proposals for the American Transplant Congress in May in Boston, MA, USA, and contributed to the educational content of a Joint IPTA/TTS Pediatric Post Graduate Course at the 26th International Congress of The Transplantation Society in August 2016 in Hong Kong. The Pediatric PG Course reviews listing criteria for children undergoing solid organ transplantation and donor selection, and provides insights on specific aspects of post-transplant care in children.

In the meantime, the Education Committee has already started to organize the educational content of the PG Course planned at the start of the upcoming 9th IPTA Congress to be held in Barcelona, Spain, in May 2017.

ID CARE COMMITTEE UPDATE
Upton Allen, ID CARE Committee Chair

The ID-CARE initiative was formed within IPTA with the idea that one of its main goals would be to serve as the focal point for ID initiatives and to link IPTA with other ID groups where appropriate. The focus is ID Clinical Care, Advocacy, Research and Education. The Committee seeks to engage IPTA members from all disciplines within pediatric organ stem cell transplantation.

The ID CARE Committee has been involved in several initiatives, some of which have been published in Pediatric Transplantation (Curriculum-related documents). In keeping with this approach, the group is currently working on a document that focuses on the evaluation and management of transplant candidates or recipients with recent active infections. A first draft of this document has been completed and submission to Pediatric Transplantation is expected in Fall 2016. The leads are Arnaud L’Huillier, Upton Allen and Michael Green.

The group has also identified other projects which are at varying stages of completion. Among these are the following:

  1. Status of use of live vaccines after pediatric solid organ. Klara Pofsay-Barbe is leading this initiative. In addition, a survey of current practices has been proposed.
  2. Pneumocystis prophylaxis strategies across transplant centers. This is being led by Mignon McCulloch and Marian Michaels.
  3. TB and Transplantation: A Pediatric Perspective. This initiative is led by Mignon McCulloch.
  4. Yearly Influenza update. This has been proposed as the first in the series of yearly influenza updates be led by Natasha Halasa. This will focus on what is new in influenza molecular epidemiology, antiviral drug resistance, vaccines, treatment and chemoprophylaxis with a focus on immunocompromised patients, notably transplant patients.
Over the upcoming months, the group looks forward to engaging representation from the HSCT group. Collaborations on selected documents or guidelines will also occur. These included, but are not limited to cytomegalovirus (CMV) or Post-transplant lymphoproliferative disorder (PTLD).

PEDIATRIC TRANSPLANTATION
UPDATE

PETR latest cover file

Wiley, publisher of Pediatric Transplantation has announced the acquisition of Atypon, one of the world’s leading scientific and scholarly information platform providers.

Wiley is very excited about joining up with our new colleagues at Atypon to bring you the best publishing technology in the industry. Atypon shares our values and focus on the researcher, and working with them is a natural extension of our commitment to providing flexibility to our partners and increasing digital engagement for readers.

Over the next 18 months, we’ll migrate from the platform supporting the Wiley Online Library to Atypon’s Literatum platform. This will bring a number of new benefits to users, including seamless access to content through authenticated article links, improved single-sign-on, editor highlights, article usage metrics, site-wide fully responsive mobile design, minimal-downtime releases, targeted content marketing, article recommendations and e-mail alerting, and more powerful search. This approach will allow us to more rapidly and flexibly respond to the changing needs of the communities we serve.

Wiley will join a diverse array of organizations currently using Atypon’s platform, including societies like the American Chemical Society, Massachusetts Medical Society (publishers of The New England Journal of Medicine), and the American Society of Civil Engineers; publishers such as Elsevier, Sage, and Taylor & Francis, and university presses.

This acquisition is part of our commitment at Wiley to supporting the advancement of scientific and scholarly research and helping authors to reach the widest audience possible and to create impact for their research, investing in the industry’s best technology experience and curating and protecting the version of record.

International Pediatric Transplant Association May 2016 Newsletter

Dear Members, Colleagues and Friends,

The Council of the International Pediatric Transplant Association (IPTA) is pleased to provide an update of our Association's activities.

In 2015 our Association joined The Transplantation Society (TTS) as a new official Section, and with its approximately 600 members from more than 50 countries, IPTA has become the largest section of TTS. We are confident that all our members will be able to take advantage of the synergies resulting from increased cooperation and the strengthening of our transplantation network. IPTA will also contribute to the educational content of the upcoming TTS Congress in Hong Kong, August 18-23, 2016. In the meantime, preparations are well under way for the upcoming 9th Congress of the IPTA, which will be held in Barcelona, Spain, from May 27-30, 2017. The Scientific Advisory Committee consisting of both IPTA and TTS members has been set up and looks forward to your suggestions and participation.

The biennial congress is just one example of the international work of the Association. Founded in 1998, IPTA is the only Association worldwide devoted to the special needs of pediatric transplant patients and their families. IPTA has been involved in outreach and in fellow education, has its own journal Pediatric Transplantation and has sponsored the publication of two textbooks on pediatric solid organ transplantation. Affiliation with TTS is a natural fit for IPTA, as both organizations take an international approach to transplantation and are mutually committed to education and strengthening collaboration in the field.

Warm regards,

Burkhard Tönshoff
IPTA President

 

Summary of the IPTA 8th Congress in San Francisco, USA, March 28-31, 2015
Burkhard Tönshoff, Congress Chair

The IPTA 8th Congress, which was held in in San Francisco, USA, on March 28-31, 2015, was a great achievement (http://2015.iptaonline.org/). This Congress is held every two years, traditionally in off years of the TTS Congress, and is one of the most, if not the most important activity of our Association. The objective was to bring transplant professionals together in order to learn about the latest scientific developments in pediatric transplantation. The Congress included plenary sessions, state-of the-art presentations, special lectures, interactive workshops and two post-graduate courses, one for transplant physicians and one for allied health members; the contribution and representation of allied health workers, who currently represent 16% of our membership, has always been an important part of our Association. The number of participants was over 500; 54% from North America, 24% from Europe, 10% from Asia, 6% from Austro-Asia, 4% from South America and 2% from Africa. The Congress provided a unique atmosphere to share and discuss recent development in the field of pediatric transplantation. Of the 291 accepted abstracts representing 36 countries, 109 were presented as oral communications and 182 were presented in poster sessions. Four young participants were awarded with the “Early Investigator Abstract Award”.

We wish to express our sincere gratitude to Lars Pape (Congress Co-Chair) and Paul Grimm, Minnie Sarwal and Peter Stock (Local Organizing Committee Co-Chair) and to all contributors and participants who made this event a great success.

The presentations have been recorded and are available for free to all IPTA and TTS Members in the Members Only area of the IPTA website https://www.tts.org/ipta/home. Information on the program topics can be found on the congress website http://2015.iptaonline.org/ and in a supplement edition of our journal “Pediatric Transplantation” (volume 19, supplement 1, May 2015), where all of the 291 presented abstracts are published.

 

IPTA Fellows Meeting New York City, USA, April 8-9, 2016
Ron Shapiro, Meeting Chair

The biennial IPTA Fellow’s Symposium took place this year in New York City. With 25 fellows from around the world and a core faculty of international experts in the field of pediatric transplantation, the Fellow’s Symposium provided both a formal curriculum of updates in all areas of pediatric transplantation and an informal setting for networking and mentoring. This has been a popular and educational meeting, and this was its North American debut in New York City, at the Recanati/Miller Transplantation Institute. The scientific program was compiled by the IPTA Education Committee and Executive Committee. Participants had the opportunity to learn about the field or pediatric solid organ transplantation from experts in both basic science and clinical care while working within small interactive groups. Fellows each presented abstracts and interesting cases were discussed, in addition to the core lectures. The meeting offered important insights about career development by access to expert faculty. Attendees were selected based on the score of their abstract submission. We gratefully acknowledge the support of the IPTA Fellows Meeting by a grant from the TTS and Novartis. The final program is available on the IPTA homepage and recordings of all the sessions can be found on the website in the Resources section and accessed with your member login.

 

IPTA 9th Congress in Barcelona, Spain, May 27-30, 2017
Anne Dipchand, Congress Chair

Save the Date!! The International Pediatric Transplant Association will be holding its 9th Congress in Barcelona, Spain, from May 27-30, 2017. Come and join us in the cradle of Catalan culture! Founded as a Roman City in the Middle Ages and particularly renowned for the architectural works of Antoni Gaudí and Lluís Domènech i Montaner. Barcelona has a rich heritage and is an important cultural centre and major tourist destination. The IPTA scientific sessions will take place overlooking the blue waters of the Mediterranean Sea at the World Trade Center Barcelona, centrally located on Barcelona’s most well connected main road…. just a few steps away from an extensive range of amenities, shops and services.

This unique Congress will bring together world leaders in the field of pediatric transplantation from Australia, Asia, and the Americas, in addition to featuring outstanding local and regional experts from Spain and Europe. They will share cutting edge innovations and address important needs for clinical and experimental transplant therapy with an anticipated international audience of 500 including physicians, surgeons, nurses and a broad range of interdisciplinary team members and trainees. There will be something for everyone involved in the care of children undergoing solid organ transplantation. Come and hear the latest advances in transplantation research, both clinical and basic:

  • The newest technologies in immunology and transplant research
  • Updates and new data from ongoing pediatric transplant clinical trials (CTOT-C)
  • Long-term complications following transplantation
  • Standards for surveillance and treatment of infections in transplantation
  • Perspectives in immune tolerance
  • Up-to-date data from important registries
  • Protocols to minimize immunosuppression
  • New and emerging immunosuppressive agents
  • Appropriate selection of adult donor organs to be used for pediatric recipients
  • Ethical dilemmas in pediatric transplantation
  • Organ Donation
  • Devices used to support transplantation
  • Issues in noncompliance and transfer of care
  • Clinical trial design and endpoints for testing new therapies in children.

In a vibrant Opening Ceremony on Saturday May 26th, learn about the strategies behind the success of the Spanish organ donation system and get empowered by shared experiences from the World Transplant Games, also taking place in Spain in 2017. Refresh yourself at one of the two planned post-graduate courses also on Saturday. Scientific sessions will include world renowned plenary and state-of-the art speakers, the very popular parallel interactive workshop sessions with experts in the field, and organ-specific abstract sessions. Catch up with old friends and colleagues over a glass of wine while discussing posters from around the world. Experience the history of medicine in Spain in at the Hospital San Pau during the congress social evening on Monday May 28th. And there is so much more…..
Looking forward to seeing you all in Barcelona!

 

IPTA Outreach Committee Visits Cape Town, South Africa
Mignon McCulloch and Nancy Poirer

The Red Cross Children’s Hospital is attached to the University of Cape Town (UCT) and is currently the only University Hospital in Africa offering cardiac transplantation. This follows a history of the first successful Adult Cardiac Transplant performed in 1967 at Groote Schuur Hospital (also part of UCT).

The last paediatric cardiac transplant was performed in 2007 with none since then for various reasons including organizational issues. The team had lost confidence to restart the program again and so applied to the IPTA Outreach Program for assistance. The IPTA Outreach Committee approved supporting the hospital’s application. Members of the Committee met with Mignon McCulloch (transplant physician) and Andre Brooks (paediatric cardiac surgeon) and the site visit was planned. In the year prior to the visit, a medical protocol for immunosuppression was prepared with the valuable input from Anne Dipchand, Nancy Poirier as well as Richard Kirk. This protocol was also adapted for local conditions including issues such as TB prophylaxis and high incidence of PJP.

For the three day site visit, a group of potential transplant team members were identified and a series of discussion meetings were held using Nancy as the ‘external mediator/wise mentor’. During this time discussions were held putting forward potential solutions to the local challenges, creating organizational structures and planning a patient pathway. The meetings were all inclusive of staff from many areas including specifically the CEOs of Red Cross and Groote Schuur Hospitals as well as physicians, surgeons, PICU staff, Pharmacy and social workers just to name a few. At the conclusion of the visit, the patient pathway was implemented and action points produced identifying various role players and introducing an organizational structure.

Since the visit, six patients have been assessed with three being deemed unsuitable surgical candidates. The remaining three were listed for the program. Unfortunately, currently there is no auxiliary support such as assist devices or ECMO and these three patients demised awaiting a transplant in December 2015. Lessons learned were that these patients could possibly have been listed earlier and the need for auxiliary support. In parallel, Nancy Poirier and Andre Brooks with help from the ECMO team at Birmingham Children’s Hospital (UK) have run a ECMO training course in Cape Town during 2015 and a ECMO system is currently being purchased as a support system for the cardiac transplant program.

The result of the IPTA Outreach visit was a very successful rejuvenation in interest, organization and collaboration between the local team in Cape Town with a strong motivation to facilitate the re-commencement of this program using local skills, as well as international collaboration and support.

Subsequent to the visit, the awareness of paediatric cardiac transplantation elsewhere in South Africa has improved and there is now collaboration with a centre in Johannesburg to support and start a second program there. A follow-up visit once the ECMO program is established may be required but to date the local teams are very motivated and grateful to IPTA for the outreach support and successful visit.

 

IPTA Practice Recommendations a new type of article for our journal Pediatric Transplantation
Guido Filler and Burkhard Tönshoff

The IPTA Publications Committee has proposed a new type of article for our journal Pediatric Transplantation called IPTA Practice Recommendations. These recommendations use similar levels of evidence as the more elaborate practice guidelines such as the KDIGO guidelines, but the process does not include the same extensive literature review, because of the smaller evidence-base in the pediatric transplant literature. The policy and procedure for the review and approval of IPTA practice recommendations are as follows: (i) Each publication of Practice Recommendations drafted by the IPTA Publication Committee receives IPTA endorsement by an Ad Hoc Committee of experts with a short turnaround time of seven working days. This Ad Hoc Committee consists of 2–4 people from the IPTA Council (non-authors) and is appointed by the IPTA Executive. (ii) The manuscript, which has been revised according to the suggestions of the Ad Hoc Committee, is submitted to the journal Pediatric Transplantation, where it undergoes the regular peer review process. (iii) The manuscript, which has been revised according to the suggestions of the reviewers of Pediatric Transplantation, is reviewed and approved by the IPTA Council. (iv) The manuscript is then posted on the IPTA website as a draft and an email will be circulated to the IPTA membership and with a ten day period outlined for public commentary and feedback to be sent to the main author. The first practice recommendations will deal with the monitoring and management of renal dysfunction after pediatric non-renal transplantation, because there is increasing evidence that renal dysfunction is a major confounder for the survival of non-renal pediatric solid organ transplant recipients. This first IPTA Practice Recommendation has recently be published in our journal “Pediatric Transplantation” (Pediatr Transplant 2016 Feb 25. doi: 10.1111/petr.12685).

 

Our journal “Pediatric Transplantation” is going green
Steve Webber, Editor-in-Chief, Pediatric Transplantation

Starting in 2016, Pediatric Transplantation will transition to online-only publication, which means that IPTA members will no longer receive printed issues of the journal. Established in 1997, Pediatric Transplantation has made the decision to move online after 19 years of publishing to better meet the evolving needs of the research and clinical communities. Online-only publication will allow the journal to focus on improving the quality of its digital experience for authors and readers by adding value and functionality to journal articles.

The second change relates to a new Wiley network of transplant journals. If an article is submitted to one Wiley journal, and not accepted, this creates a path for the article to be offered to other Wiley transplant journal(s) (with the authors’ approval). The article will be forwarded along with prior reviews, thus accelerating the review process at the second journal for both the authors and the editorial team. To standardize processes across the Wiley transplant journals, there will be some tweaking of the authors submission web pages and the reviewers' templates.