Issue 2 - Volume 1 - October 2021
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This quarterly newsletter highlights the latest and most relevant publications in our field, as well as association news, and updates on meetings and educational activities.

In This Issue

  • The IPITA 2021 Virtual Congress last chance to register
  • IPITA Business Meeting Announcement
  • We have compiled a list of Recent Publications of interest to our field
Steven Paraskevas
Editor, Beta-Cell Bulletin
IPITA Education Committee

Bulletin Contributors:

A special thanks to our Education Committee Members & Bulletin Contributors: :

Pancreas Section:
Pancreas: Jonathan Fridell, Angelika Gruessner, Silke Neiderhaus.

Islet and Beta-Cell Sections:
Christian Schutz, Paola Maffi, Leticia Labriola, Alice Tomei, Amish Asthana, Barbara Ludwig, Giuseppe Orlando, Fabio Vistoli./p>

New IPITA Educational Initiative

On behalf of the International Pancreas and Islet Transplantation Association (IPITA) Council, we would like to share with you an exciting new initiative, the "IPITA Curriculum on Pancreas & Islet Cell Transplantation".
Read More

A main focus of IPITA is to promote training in the field of pancreas and islet cell transplantation and it is our hope that this new initiative will advance this goal.

We developed this curriculum in collaboration with investigators and clinicians from around the world with the purpose of providing the community with a comprehensive educational resourse both for trainees, and seasoned professionals in our field seeking to update their practice.

The curriculum is free for IPITA and TTS members through the member portal on and Those who are not yet members may signup for soley for the curriculum or sign-up and become a member of IPITA at the same time. We have priced the Curriculum to make this as attractive as possible to recruit new members.


All IPITA members are invited to join the Business Meeting taking place at the IPITA Virtual Congress on Friday October 22 at 2:15PM EDT

Business meeting agenda is as follows:

  • IPITA President, James Markmann will highlight the council activities over the last two years
  • Review of the Association’s Financial Status
  • Review of the Membership Status
  • Presentation – 2021 Derek Gray Distinguished Traveling Scholarship Award
  • Outgoing and incoming members of council will be announced.
  • New President of IPITA for the (2021-2023 term) will be introduced
  • Location and date of 2023 Congress will be announced.
  • Open discussion and Q&A

Members will be emailed the link on October 18

IPITA 2021


  • Three days of cutting-edge clinical data and updates on state-of-the-art research
  • A pre-congress COVID-19 workshop on understanding the links between diabetes and transplant
  • A panel of truly global experts and key opinion leaders
  • Innovative presentation formats to maximize engagement
  • Networking opportunities to make important professional connections

Pancreas Transplantation

Technical factors that minimize the occurrence of early graft failure in pancreas transplantation
Je Ho Ryu, Hyo Jung Ko, Jar Ryong Shim, Tae Beom Lee, Kwang Ho Yang
Clinical Transplantation, 2021
Donor insulin therapy in intensive care predicts early outcomes after pancreas transplantation
Iestyn M. Shapey, Angela Summers, Hussein Khambalia, Petros Yiannoullou, Catherine Fullwood, Neil A. Hanley, Titus Augustine, Martin K. Rutter, David van Dellen
Diabetologia, 2021, 10.1007/s00125-021-05411-9
Single center results of simultaneous pancreas‐kidney transplantation in patients with type 2 diabetes
Phuoc H. Pham, Lily N. Stalter, Eric J. Martinez, Jesse F. Wang, Bridget M. Welch, Glen Leverson, Nicholas Marka, Talal Al‐Qaoud, Didier Mandelbrot, Sandesh Parajuli, Hans W. Sollinger, Dixon Kaufman, Robert R. Redfield, Jon S. Odorico
American Journal of Transplantation, 2021, 10.1111/ajt.16462
Pancreas transplantation perceptions and practice: Results from a national US survey
Ronald F. Parsons, Abraham Matar, Krista L. Lentine, Kenneth J. Woodside, Neeraj Singh, Tarek Alhamad, Arpita Basu, Franco H. Cabeza Rivera, Wisit Cheungpasitporn, Giulio Romeo, Swati Rao, Clark D. Kensinger, Sandesh Parajuli, Samuel Sultan, Ekamol Tantisattamo, Martha Pavlakis, Matthew Cooper
Clinical Transplantation, 2021, 10.1111/ctr.14432
Metabolic outcomes and renal function after simultaneous kidney/pancreas transplantation compared with kidney transplantation alone for type 2 diabetes mellitus patients
Yingxin Fu, Yu Cao, Hui Wang, Jie Zhao, Zhen Wang, Chunbai Mo, Xiaofeng Shi, Gang Feng, Wenli Song
Transplant International, 2021, 10.1111/tri.13892

Islet Transplantation

Fibroblast growth factor 7 releasing particles enhance islet engraftment and improve metabolic control following islet transplantation in mice with diabetes
Salamah M. Alwahsh, Omar Qutachi, Philip J. Starkey Lewis, Andrew Bond, June Noble, Paul Burgoyne, Nik Morton, Rod Carter, Janet Mann, Sofia Ferreira‐Gonzalez, Marta Alvarez‐Paino, Stuart J. Forbes, Kevin M. Shakesheff, Shareen Forbes
American Journal of Transplantation, 2021, 10.1111/ajt.16488
PRISM: A Novel Human Islet Isolation Technique
Jason B Doppenberg, Marten A Engelse, Eelco J P de Koning
Transplantation, 2021, 10.1097/tp.0000000000003897
The impact of islet mass, number of transplants, and time between transplants on graft function in a national islet transplant program
Shareen Forbes, Anneliese J. Flatt, Denise Bennett, Robert Crookston, Mirka Pimkova, Linda Birtles, Andrew Pernet, Ruth C. Wood, Keith Burling, Peter Barker, Claire Counter, Alistair Lumb, Pratik Choudhary, Martin K. Rutter, Miranda Rosenthal, Andrew Sutherland, John Casey, Paul Johnson, James A. M. Shaw
American Journal of Transplantation, 2021, 10.1111/ajt.16785
Long-term Persistence of Allosensitization After Islet Allograft Failure
Paola Rios, David Baidal, Joana Lemos, Stephanie S Camhi, Marco Infante, Nathalia Padilla, Ana M Alvarez Gil, Virginia Fuenmayor, Jonathan Ambut, Fatima A Qasmi, Alejandro M Mantero, Shari Messinger Cayetano, Phillip Ruiz, Camillo Ricordi, Rodolfo Alejandro
Transplantation, 2021, 10.1097/tp.0000000000003635
Performance of modified Igls criteria to evaluate islet autograft function after total pancreatectomy with islet autotransplantation – a retrospective study
Kendall R. McEachron, Yi Yang, James S. Hodges, Gregory J. Beilman, Varvara A. Kirchner, Timothy L. Pruett, Srinath Chinnakotla, Bernhard J. Hering, Melena D. Bellin
Transplant International, 2021, 10.1111/tri.13762
Ten‐year outcomes of islet transplantation in patients with type 1 diabetes: Data from the Swiss‐French GRAGIL network
Sandrine Lablanche, Sophie Borot, Anne Wojtusciszyn, Kristina Skaare, Alfred Penfornis, Paolo Malvezzi, Lionel Badet, Charles Thivolet, Emmanuel Morelon, Fanny Buron, Eric Renard, Igor Tauveron, Oriane Villard, Marion Munch, Salomé Sommacal, Léa Clouaire, Morgane Jacquet, Laura Gonsaud, Coralie Camillo‐Brault, Cyrille Colin, Jean‐Luc Bosson, Domenico Bosco, Thierry Berney, Laurence Kessler, Pierre‐Yves Benhamou, the GRAGIL Network
American Journal of Transplantation, 2021, 10.1111/ajt.16637
Lower beta cell yield from donor pancreases after controlled circulatory death prevented by shortening acirculatory warm ischemia time and by using IGL-1 cold preservation solution
Diedert L. De Paep, Freya Van Hulle, Zhidong Ling, Marian Vanhoeij, Jacques Pirenne, Bart Keymeulen, Daniel Pipeleers, Daniel Jacobs-Tulleneers-Thevissen
PLOS ONEm 2021, 10.1371/journal.pone.0251055

Beta-Cell Science

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes
Leonore Wigger, Marko Barovic, Andreas-David Brunner, Flavia Marzetta, Eyke Schöniger, Florence Mehl, Nicole Kipke, Daniela Friedland, Frederic Burdet, Camille Kessler, Mathias Lesche, Bernard Thorens, Ezio Bonifacio, Cristina Legido-Quigley, Pierre Barbier Saint Hilaire, Philippe Delerive, Andreas Dahl, Christian Klose, Mathias J. Gerl, Kai Simons, Daniela Aust, Jürgen Weitz, Marius Distler, Anke M. Schulte, Matthias Mann, Mark Ibberson, Michele Solimena
Nature Metabolism, 10.1038/s42255-021-00420-
Multiomics single-cell analysis of human pancreatic islets reveals novel cellular states in health and type 1 diabetes
Maria Fasolino, Gregory W. Schwartz, Maria L. Golson, Yue J. Wang, Ashleigh Morgan, Chengyang Liu, Jonathan Schug, Jinping Liu, Minghui Wu, Daniel Traum, Ayano Kondo, Catherine L. May, Naomi Goldman, Wenliang Wang, Michael Feldman, Jason H. Moore, Alberto S. Japp, Michael R. Betts, Robert B. Faryabi, Ali Naji, Klaus H. Kaestner, Golnaz Vahedi
bioRxiv, 10.1101/2021.01.28.428598
Structural and functional polarisation of human pancreatic beta cells in islets from organ donors with and without type 2 diabetes
Louise, Cottle, Wan Jun Gan, Ian Gilroy, Jaswinder S. Samra, Anthony Gill, Thomas Loudovaris, Helen E. Thomas, Wayne J. Hawthorne, Melkam A. Kebede, Peter Thorn
Diabetologia, 2021, 64:618-29.
Chronically Elevated Exogenous Glucose Elicits Antipodal Effects on the Proteome Signature of Differentiating Human iPSC-Derived Pancreatic Progenitors
Luiza Ghila, Thomas Aga Legoy, Andreas Froslev Mathisen, Shadab Abadpour, Joao A. Paulo, Hanne Scholz, Helge Raeder, Simona Chera
International Journal of Molecular Sciences, 2021, 22, 3698.
A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes
Xi Wang, Kristina G. Maxwell, Kai Wang, Daniel T. Bowers, James A. Flanders, Wanjun Liu, Long-Hai Wang, Qingsheng Liu, Chengyang Liu, Ali Naji, Yong Wang, Bo Wang, Jing Chen, Alexander U. Ernst, Juan M. Melero-Martin, Jeffrey R. Millman, Minglin Ma
Science Translational Medicine, 2021, 10.1126/scitranslmed.abb4601
Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models
Yasaman Aghazadeh, Frankie Poon, Farida Sarangi, Frances T.M. Wong, Safwat T. Khan, Xuetao Sun, Rupal Hatkar, Brian J. Cox, Sara S. Nunes, M. Cristina Nostro
Cell Stem Cell, 2021, 10.1016/j.stem.2021.08.001


Current and future therapies for type 1 diabetes
Bernt Johan von Scholten, Frederik F. Kreiner, Stephen C. L. Gough, Matthias von Herrath
Tissue engineering and 3D printing of bioartificial pancreas for regenerative medicine in diabetes
Andreas A.P. Soetedjo, Jia Min Lee, Hwee Hui Lau, Guo Liang Goh, Jia An, Yexin Koh, Wai Yee Yong, Adrian Kee Keong Teo
Trends in Endocrinology and Metabolism, 2021, 32(8), 609-622
Human pluripotent stem cell-derived insulin-producing cells: A regenerative medicine perspective
Adriana Migliorini, Maria Cristina Nostro, Julie B. Sneddon
Cell Metabolism, 2021, 33(4), 721-731.
Preventing type 1 diabetes in Childhood
Colin Dayan, Rachel EJ Besser, Richard A Oram, William Hagoplan, Manu Vatish, Owen Bendour-Samuel, Matthew D. Snape, John A Todd
Science, 2021, 373, 506-510.
Immunotherapy: Building a bridge to a cure for type 1 diabetes
Jeffrey A. Bluestone, Jane H. Buckner, Kevan C. Herold
Science, 2021, 10.1126/science.abh1654
Strategies for durable β cell replacement in type 1 diabetes
Todd M. Brusko, Holger A. Russ, Cherie L. Stabler
Science, 2021, 10.1126/science.abh1657
Transplant Options for Patients With Diabetes and Advanced Kidney Disease: A Review
Aleksandra Kukla, Pedro Ventura-Aguiar, Matthew Cooper, Eelco J.P. de Koning, David J. Goodman, Paul R. Johnson, Duck J. Han, Didier A. Mandelbrot, Martha Pavlakis, Frantisek Saudek, Marie-Christine Vantyghem, Titus Augustine, Michael R. Rickels
American Journal of Kidney Diseases, 2021, 10.1053/j.ajkd.2021.02.339
Supplying Insulin while Evading Immunity
Peter C. Butler
New England Journal of Medicine, 2021, 10.1056/nejmcibr2028410
Beta-cell function and human islet transplantation: can we improve?
Jennifer Chen, Jenny E Gunton
Journal of Endocrinology, 2021, 10.1530/joe-20-0590
Transplantation of stem cell-derived pancreatic islet cells
Giacomo Lanzoni, Camillo Ricordi
Nature Reviews Endocrinology, 2021, 10.1038/s41574-020-00430-9
US food and drug administration (FDA) panel endorses islet cell treatment for type 1 diabetes: A pyrrhic victory?
Lorenzo Piemonti, Axel Andres, John Casey, Eelco Koning, Marten Engelse, Robert Hilbrands, Paul Johnson, Bart Keymeulen, Julie Kerr‐Conte, Olle Korsgren, Roger Lehmann, Torbjörn Lundgren, Paola Maffi, Francois Pattou, Frantisek Saudek, James Shaw, Hanne Scholz, Steve White, Thierry Berney
Transplant International, 2021, 10.1111/tri.13930

Consensus Conference Recommendations

First world consensus conference on pancreas transplantation: Part I—Methods and results of literature search
Ugo Boggi, Fabio Vistoli, Piero Marchetti, Raja Kandaswamy, Thierry Berney, the World Consensus Group on Pancreas Transplantation
American Journal of Transplantation, 2021, 10.1111/ajt.16738
First World Consensus Conference on pancreas transplantation: Part II – recommendations
Ugo Boggi, Fabio Vistoli, Axel Andres, Helmut P. Arbogast, Lionel Badet, Walter Baronti, Stephen T. Bartlett, Enrico Benedetti, Julien Branchereau, George W. Burke, Fanny Buron, Rossana Caldara, Massimo Cardillo, Daniel Casanova, Federica Cipriani, Matthew Cooper, Adamasco Cupisti, Josè Davide, Cinthia Drachenberg, Eelco J. P. Koning, Giuseppe Maria Ettorre, Laureano Fernandez Cruz, Jonathan A. Fridell, Peter J. Friend, Lucrezia Furian, Osama A. Gaber, Angelika C. Gruessner, Rainer W.G. Gruessner, Jenny E. Gunton, Duck‐Jong Han, Sara Iacopi et al.
American Journal of Transplantation, 2021, 10.1111/ajt.16750
Examination of the Igls Criteria for Defining Functional Outcomes of β-cell Replacement Therapy: IPITA Symposium Report
Cyril P Landstra, Axel Andres, Mikael Chetboun, Caterina Conte, Yvonne Kelly, Thierry Berney, Eelco J P de Koning, Lorenzo Piemonti, Peter G Stock, François Pattou, Marie-Christine Vantyghem, Melena D Bellin, Michael R Rickels
The Journal of Clinical Endocrinology & Metabolism, 2021, 10.1210/clinem/dgab386



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