SURGERY AND IMAGING - ADVANCES

D.M. Ridgway¹, P.J. Goldsmith¹, J. Barrie¹, C. Newstead², A. Joyce³, J. Cartledge³, M. Attia¹, S. Pollard¹, N. Ahmad¹, K.V. Menon^1
1Organ Transplantation, St James's University Hospital, Leeds/UNITED KINGDOM, ²Nephrology, St James's University Hospital, Leeds/UNITED KINGDOM, ³Urology, St James's University Hospita, Leeds/UNITED KINGDOM

Body: Introduction: The use of living donors forms 36% of total renal transplant activity in the UK. Living donor grafts provide superior patient and graft survival compared to deceased donor transplantation. Donor age and obesity are important selection criteria for optimal quality grafts and donor health. This paper studies the outcomes of donor:recipient matched and mismatched renal transplantation in a live donor programme.
Methods: Short-term outcome following live donor renal transplantation in Leeds were studied in the period January 2005 to January 2009. Group A comprised donor:recipient pairs where donor age was greater than recipient age; Group B where donor age was less than recipient age. Group C comprised donor:recipient pairs where donor BMI was greater than recipient BMI: Group D where donor BMI was less than recipient BMI. Estimated GFRs were calculated using the 4 variable MDRD formula. Ordinal data were compared using a student t test.
Results: 145 live donor nephrectomies were performed using 86 female and 59 male donors. 94 nephrectomies were performed using an open technique and 51 using a laparoscopic retrieval. Mean donor and recipient ages in Group A were 49±11yrs and 33±13yrs respectively; in Group B these were 43±12yrs and 50±12yrs respectively. Mean donor and recipient BMIs in Group C were 28±3 and 23±3 kg/m² respectively; and in Group D these were 25±3 and 28±4 kg/m² respectively. Estimated 6 month GFRs differed significantly between Groups A and B (mean eGFR 55±17 vs 52±12 ml/min; p=0.011) but not in Groups C and D (mean eGFR 55±16 vs 51±13 ml/min; p=0.399).
Discussion: Discrepancies in BMI between live kidney donor and recipient have no impact on short-term graft function. Grafts from older donors, transplanted into younger recipients, show a significantly superior function in the short term.

Disclosure: All authors have declared no conflicts of interest.