SURGERY AND IMAGING - ADVANCES

M. Bieniasz¹, A. Kwiatkowski², J. Gozdowska³, R. Kieszek², P. Domagala², P. Pruszczyk⁴, D. Kecik⁵, M. Durlik⁶, L. Paczek⁷, A. Chmura^2
1General And Transplantation Surgery, Medical University of Warsaw, Warsaw/POLAND, ²Department Of General Surgery And Transplantology, Medical University of Warsaw, Infant Jesus Clinical Hospital, Warsaw/POLAND, ³Department Of Transplantation Medicine And Nephrology, Medical University of Warsaw, Warsaw/POLAND, ⁴Internal Medicine And Cardiology, Medical University of Warsaw, Warsaw/POLAND, ⁵Ophtalmology, Warsaw Medical University, Warsaw/POLAND, ⁶Dept Of Transplantation Medicine And Nephrology, Warsaw Medical School, Warsaw/POLAND, ⁷Department Of Immunology, Transplantology And Internal Medicine, Medical University of Warsaw, Infant Jesus Clinical Hospital, Warsaw/POLAND

Body:
Background. TGF-β is involved in the pathogenesis of hypertension and the development of hypertensive target organ damage. TGF-β induces renal fibrosis and contributes to the development of hypertensive target organ. The objective of the study was to evaluate the serum TGF-β concentration in living kidney donors. Patients and methods. A total of 66 living donor open nephrectomies were performed in the Department of General and Transplantation Surgery between 1995 and 2005. Physical examination, blood and urine tests, ECG, ABPM, cardiac sonography and ophtalmoscopy were performed. Serum TGF-β concentrations were measured by ELISA. Donor mean age at a follow-up visit was 46.14 years. Mean observation period was 65.6 months. 26 donors did not report for follow-up visits. The statistical analysis was performed using computer program SPSS version 13.0. Results. Hypertension was observed in 24% (5/21) women and in 37% (7/19) men after surgery. No significant difference was found between the incidence of hypertension in living kidney donors after nephrectomy and in the general population in Poland. The incidence of cardiovascular episodes in the donors was significantly lower than that of the general population in Poland. Mean serum TGF-β concentration was 39.32 ng/ml. Mean GFR according to aMDRD equation was 67.7 ml/min. It was found the decreased serum TGF-β concentration in 17 (42.5%) donors. The increased serum TGF-β concentration was observed in 9 (22.5%) donors. No significant differences were observed between TGF-β and GFR (R=-0.033, p=0.85). No significant differences were observed between hypertensive and normotensive donors (p=0.61). It was found the significantly higher TGF-β concentration in 4 and 5 years after donation (p=0.02). No correlation between TGF-β concentration in smokers and non-smokers was found. Conclusions. TGF-β is not associated with hypertension and GFR in living kidney donors after nephrectomy. Keywords: TGF-β, living kidney donors, hypertension.

Disclosure: All authors have declared no conflicts of interest.