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Presenter: Zurab, Kakabadze, Tbilisi, Georgia
Authors: Zurab Kakabadze1,2,3, Nickolas Kipshidze3, Konstantin Mardaleishvili1,4, Gocha Shatirishvili4, George Loladze4, Akaki Archvadze3, Merab Janelidze2,3, Ekaterine Berishvili1,2,3,4
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Autologous transplantation of bone marrow mononuclear cells in patients with decompensated cirrhosis
Zurab Kakabadze1,2,3, Nickolas Kipshidze3, Konstantin Mardaleishvili1,4, Gocha Shatirishvili4, George Loladze4, Akaki Archvadze3, Merab Janelidze2,3, Ekaterine Berishvili1,2,3,4
1Department of Clinical Anatomy, Tbilisi State Medical University; 2Division of Cell Transplantation, Georgian National Institute of Medical Research; 3Cell Transplantation Unit, Central University Hospital; 4Cell Transplantation Unit, Cell Therapy and Technology Center, Tbilisi, Georgia
Background: Liver cirrhosis is characterized by distortion of the hepatic architecture and the formation of regenerative nodules. Liver transplantation is one of the few available therapies for such patients. It has been shown recently, that hat bone marrow cell infusion repairs liver fibrosis in the cirrhotic liver.
Methods: This study was performed to determine the safety and tolerability of intrahepatic transplantation of autologous bone marrow mononuclear cells into ten patients with liver insufficiency. The bone marrow mononuclear cells were isolated and infused into liver via hepatic artery. At different time points after the transplantation, the liver function and prothrombin time (PT) were evaluated, and the survival rate and symptoms of the patients were recorded.
Results: No complications or specific side effects related to the procedure were observed; six patients showed improvements in serum albumin, bilirubin and ALT after one month from the cell infusion.
Conclusion: Our study has shown both the safety and feasibility of this type of liver cell therapy and may be a bridge to liver transplantation
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