This page contains exclusive content for the member of the following sections: TTS. Log in to view.
Presenter: Andrzej, Adamowicz, Bydgoszcz, Poland
Authors: Adamowicz A., Stróżecki P., Serafin Z., Włodarczyk Z., Manitius J., Lasek W.
COMPLICATIONS - CARDIOVASCULAR
A. Adamowicz1, P. Stró?ecki2, Z. Serafin3, Z. W?odarczyk1, J. Manitius2, W. Lasek3
1Dept Of Transplantology And Surgery, Collegium Medicum UMK, Bydgoszcz/POLAND, 2Dept Of Nephrology, Hypertension And Internal Diseases, Collegium Medicum UMK, Bydgoszcz/POLAND, 3Dept Of Radiology And Diagnostic Imaging, Collegium Medicum UMK, Bydgoszcz/POLAND
Body: Introduction: Metabolic syndorme (MS) is a common finding among kidney transplant recipients (KTR). Coronary artery calcification (CAC) is associated with increased mortality in patients with CKD. The relationship was found between MS components and CAC in general population. In recent study in KTR the prevalence of CAC increased with the number of MS components. The aim of our study was to investigate the relationship between MS and CAC in KTR. Patients and methods: The study group consisted of 104 KTR (31 females and 73 males), aged 49±12 years. All patients received graft from deceased donors. Total duration of renal replacement therapy (RRT) was 71±47 months, and kidney transplant follow-up 38±31 months. The diagnosis of MS was based on IDF criteria. CAC was determined with multi-detector row computed tomography as total calcium score (CS) and calcium mass (CM). Systolic and diastolic blood pressure (SBP, DBP) were measured. Fasting blood was sampled for serum lipids, glucose, high-sensitive C-reactive protein (hs-CRP) and serum creatinine. Glomerular filtration rate was calculated with abbreviated MDRD equation (eGFR). Results are expressed as mean±SD Results: Criteria of MS were met in 42 KTR (40%). CAC was found in 72 patients (69%). Patients without MS and patients with MS were compared.
Parameter | MS(-) | MS(+) | P |
CAC (+) | 40 (65%) | 32 (76%) | NS |
CS | 373 ± 614 | 762 ± 1134 | NS |
CM (mg) | 63 ± 105 | 127 ± 191 | NS |
Age | 46 ± 12 | 53 ± 11 | 0,002 |
Gender (male) | 46(74%) | 27(64%) | NS |
SBP (mmHg) | 133 ± 19 | 135 ± 16 | NS |
DBP (mmHg) | 83 ± 12 | 82 ± 11 | NS |
Waist (cm) | 84 ± 12 | 98 ± 10 | < 0,001 |
BMI (kg/m2) | 23,8 ± 3,9 | 27,7 ± 3,7 | < 0,001 |
TG (mg/dl) | 135 ± 57 | 206 ± 91 | < 0,001 |
Cholesterol (mg/dl) | 201 ± 38 | 224 ± 59 | < 0,05 |
LDL-cholesterol (mg/dl) | 113 ± 30 | 121 ± 37 | NS |
HDL-cholesterol (mg/dl) | 61 ± 14 | 60 ± 17 | NS |
hs-CRP (mg/l) | 2,4 ± 3,2 | 3,3 ± 3,1 | < 0,05 |
eGFR (ml/min/1,73m2) | 58 ± 17 | 51 ± 17 | NS |
Disclosure: All authors have declared no conflicts of interest.
By viewing the material on this site you understand and accept that:
The Transplantation Society
International Headquarters
740 Notre-Dame Ouest
Suite 1245
Montréal, QC, H3C 3X6
Canada