2015-2017 - Advanced Renal Transplantation - Interactive Teaching Series


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T-Cell and Antibody-Mediated Rejection

5.1 - T-Cell and Antibody-Mediated Rejection

Presenter: Michael, Mengel, Edmonton, AB, Canada
Authors: Michael Mengel

Biography

Dr Mengel is Chair of the Department for Laboratory Medicine and Pathology at the University of Alberta, Edmonton, Canada. He is a sub-specialized Transplantation and Renal Pathologist at the Division of Anatomical Pathology, University of Alberta Hospital. Outside his faculty Dr. Mengel is engaged in various international sub-specialty societies related to nephropathology and organ transplantation: past Chair Transplant Diagnostics Community of Practice in the American Society of Transplantation; Board member International Banff Foundation for Allograft Pathology; Board member Canadian Society of Transplantation; Chair of the Research Committee International Renal Pathology Society.

He studied medicine at the Semmelweiss University in Budapest, Hungary before going on to specialise in pathology and further in transplantation pathology and nephropathology. Before moving to Edmonton he was head of the transplant pathology service at the Hannover Medical School, Germany. Dr. Mengel has published more than 170 peer-reviewed articles and his current work is focused on applying molecular techniques to biopsy specimens, with the aim to increase diagnostic precision in organ transplantation.

Learning Objectives:

  • Review current understanding of pathomechanisms leading to chronic allograft dysfunction with a specific focus on allograft rejection
  • Understand current diagnostic criteria of the Banff classification for rejection diagnosis
  • Discuss limitations in diagnosing rejection and risk stratification for treatment of rejection

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