Session 2 : Early Transplant Complications - The First 30 Days
2.0 - Managing Multidrug Resistant Organisms in HSCT and SOT
Presenter: Ban Hock, Tan, , Singapore Authors:
Because much is already known about MRSA and VRE in transplant recipients, this talk will focus on carbepenem-resistant Enterobacteriaceae (CRE) and (time permitting) other extremely drug-resistant (XDR) gram-negatives. Published experience in the treatment of serious CRE infections suggests that antibiotic combinations may be associated with improved outcomes, but a strict analysis of these non-randomized studies has categorized them as “low quality” evidence. In addition to these data, the talk will also touch on the in vitro data (promising!), the role that newer agents such as ceftazidime-avibactam could play (promising but limited), and the small but increasing number of publications hinting at the value of mandatory screening.
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