COMPLICATIONS - INFECTIONS

D. Kawecki¹, A. Kwiatkowski², A. Chmura², M. Durlik³, W. Rowinski⁴, M. Luczak¹, G. Mlynarczyk^1
1Medical Microbiology, Medical Unmiversity of Warsaw, Warsaw/POLAND, ²Department Of General Surgery And Transplantology, Medical University of Warsaw, Infant Jesus Clinical Hospital, Warsaw/POLAND, ³Dept Of Transplantation Medicine And Nephrology, Warsaw Medical School, Warsaw/POLAND, ⁴Emeritius, Medical University of Warsaw, Warsaw/POLAND

Body: Objective This study aims at evaluation of the frequency of microbial isolates and their susceptibility profiles; cultured from clinical samples obtained from blood, urine, stool, surgical site of 26 simultaneous pancreas-kidney (SPKTx) recipients suspected of bacterial infections in the early post - transplant period. Patients and methods The study covered 26 adult patients undergoing SPKTX transplantation between September 2001 and December 2006. All the patients were followed prospectively for bacterial infections from the SPKTX date and during the first four weeks after surgery. The microorganisms were cultured and identified in accordance with standard bacteriological procedures. Susceptibility testing was carried out using Clinical and Laboratory Standards Institute (CLSI) procedures. Results All the patients were followed prospectively for the first four weeks after surgery. In total: 168 microbial isolates from clinical samples from “surgical site”, 23 from “blood and tips of vessel catheters”, 30 from “urine”. The most commonly isolated were: Gram-positive bacteria with domination of staphylococci: with presence of MRCNS, MRSA strains and enteroccocii: with presence of, HLAR, VRE strains. Gram-negative bacteria: among them were isolated extended spectrum beta-lactamase producers - ESBL(+) and carbapenems resistant strains. In conclusion in our study predominated Gram(+) bacteria. The increased proportion of isolation MDR bacteria to antimicrobial agents may be due to the frequent use of these agents for prophylaxis of bacterial infections in patients. MDR strains can caused severe bacterial infections in patients after SPKTX.

Disclosure: All authors have declared no conflicts of interest.