COMPLICATIONS - INFECTIONS

M. Alghailani¹, A. Abdulbaki², A. Pall², K.A. Almeshari², H.A. Aleid^3
1, King Faisal Specialist Hospital, Riyadh/SAUDI ARABIA, ²Renal Transplant Unit, King Faisal Specialist Hospital & Research Centre, Riyadh/SAUDI ARABIA, ³Renal Transplant Unit, King Faisal Specialist Hospital, Riyadh/SAUDI ARABIA

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BACKGROUND: With the current H1N1 pandemic and the potential increased morbidity in the immunosuppressed renal transplant population, we conducted this study to test the incidence and outcome of this infection in our transplant patients. METHODOLOGY: Prospective cohort study conducted between August 2009 and 15 December 2009 examining all adult (more than 14 years old) renal transplant patients followed at KFSH&RC. Data pertaining to baseline characteristic of the affected patients, their infection and outcome where collected. RESULTS: Seven patients were diagnosed with H1N1 by PCR methodology during the study period. Three patients required admission, one of which required prolonged ICU admission, developed multiorgan failure and lost his graft. One patient developed acute kidney injury and subsequently found to have severe rejection and required temporary dialysis. One patient developed pneumonia with culture negative sputum and developed AKI that resolved with treatment. Four patients were treated as outpatient, one of which developed persistent increase of creatinine from baseline. The other three had no renal complications. Several patients were empirically treated for presumptive diagnosis of H1N1 during the study period but were not tested for H1N1. CONCLUSION: Seven patients were diagnosed with H1N1 during the study period. Several complications including pneumonia and renal dysfunction were noted in the majority of the confirmed H1N1 cases.

Disclosure: All authors have declared no conflicts of interest.