2011 - Transplantomics and Biomarkers in Transplantation

This page contains exclusive content for the member of the following sections: TTS. Log in to view.

Immune Monitoring +/- Imaging?

5.1 -

Presenter: Robert, Lechler, London, UK
Authors: Robert Lechler

Clinical Transplantation Tolerance – a fingerprint?

Robert Lechler, King’s College London, London, UK

In the past decade, an explosion in the number of high-throughput tools for the measurement of different cellular products has occurred. These tools have the potential to further our understanding of human disease and this development has facilitated the identification of new biomarkers in all areas of medicine. In the field of solid organ transplantation, two different areas have developed: the use of biomarkers to predict allograft rejection, so that parenchymal damage can be prevented before it becomes irreversible and biomarkers for the identification of patients in whom donor-specific tolerance has developed. This ability would allow the minimization or even the withdrawal of immunosuppressive therapy in selected patients, thus reducing the number of adverse effects and costs, and optimizing long-term graft outcomes.

I will discuss the development of reliable and reproducible in vitro assays capable of detecting tolerance in renal transplant recipients. How several biomarkers and bioassays were screened on patient samples that included operationally tolerant renal transplant recipients, other recipient groups and healthy controls. These results have the potential to shape drug-weaning protocols in renal transplant recipients.

Important Disclaimer

By viewing the material on this site you understand and accept that:

  1. The opinions and statements expressed on this site reflect the views of the author or authors and do not necessarily reflect those of The Transplantation Society and/or its Sections.
  2. The hosting of material on The Transplantation Society site does not signify endorsement of this material by The Transplantation Society and/or its Sections.
  3. The material is solely for educational purposes for qualified health care professionals.
  4. The Transplantation Society and/or its Sections are not liable for any decision made or action taken based on the information contained in the material on this site.
  5. The information cannot be used as a substitute for professional care.
  6. The information does not represent a standard of care.
  7. No physician-patient relationship is being established.



Staff Directory


The Transplantation Society
International Headquarters
740 Notre-Dame Ouest
Suite 1245
Montréal, QC, H3C 3X6