P-214

Improved quality of life for islet recipients under T cell depletion immunosuppression with anti-inflammatory agents

M. Takita¹, S. Matsumoto¹, M. Shimoda², D. Chujo³, T. Itoh¹, K. Sugimoto¹, J.A. SoRelle⁴, N. Onaca⁵, B. Naziruddin⁵, M.F. Levy^5
1 Baylor Research Institute Fort Worth Campus, Islet Cell Laboratory, Fort Worth, USA; ² Baylor University Medical Center at Dallas, Dallas, USA; ³ Baylor Institute for Immunology Research, Dallas, USA; ⁴ Institute of Biomedical Studies, Baylor University, Waco, USA; ⁵ Annette C. and Harold C. Simmons Transplant Institute, Dallas, USA

Objective: Islet cell transplantation (ICT) is a promising treatment for patients with type 1 diabetes. We have implemented a novel immunosuppression protocol that included anti-thymocyte globulin induction with double blockage of interleukin (IL)-1? and tumor necrosis factor (TNF)-? (Baylor protocol), resulting in highly successful, single-donor ICTs. In this study, we investigated the impact of ICTs with Baylor protocol on the quality of life (QoL) of patients.

Methods: A total 32 QoL questionnaires from four islet recipients who underwent ICTs with Baylor protocol were included. All recipients were followed for at least one year. The patients answered QoL surveys of both SF-36 and Diabetes Form 2.1 at 3, 6 and 12 months after the last ICT. These scores, where higher score indicates better QoL, were compared with baseline cohort using one-way ANOVA with least significant differences post hoc tests.

Results: All scores of QoL survey at post-ICT were higher or similar compared to those at pre-ICT (Figure 1). The scores of total average and physical functioning subscale in SF-36 at any time points of post-ICT were significantly higher than baseline (*P < 0.05). Marginally significant improvements were found in general health perceptions subscale in SF-36 and symptom index in Diabetes Form 2.1 compared to baseline (^†P = 0.05).

Conclusions: ICT with the Baylor protocol can improve the QoL especially for physical activities at one-year follow-up. Personal health perception and interference due to diabetic complication were also improved at a marginally significant level. The Baylor protocol is a feasible strategy for ICT, evidenced by the patient-reported outcome.

Figure 1. QoL scores at pre- and post-ICT with Baylor protocol.

P-214

Improved quality of life for islet recipients under T cell depletion immunosuppression with anti-inflammatory agents

M. Takita¹, S. Matsumoto¹, M. Shimoda², D. Chujo³, T. Itoh¹, K. Sugimoto¹, J.A. SoRelle⁴, N. Onaca⁵, B. Naziruddin⁵, M.F. Levy^5
1 Baylor Research Institute Fort Worth Campus, Islet Cell Laboratory, Fort Worth, USA; ² Baylor University Medical Center at Dallas, Dallas, USA; ³ Baylor Institute for Immunology Research, Dallas, USA; ⁴ Institute of Biomedical Studies, Baylor University, Waco, USA; ⁵ Annette C. and Harold C. Simmons Transplant Institute, Dallas, USA

Objective: Islet cell transplantation (ICT) is a promising treatment for patients with type 1 diabetes. We have implemented a novel immunosuppression protocol that included anti-thymocyte globulin induction with double blockage of interleukin (IL)-1? and tumor necrosis factor (TNF)-? (Baylor protocol), resulting in highly successful, single-donor ICTs. In this study, we investigated the impact of ICTs with Baylor protocol on the quality of life (QoL) of patients.

Methods: A total 32 QoL questionnaires from four islet recipients who underwent ICTs with Baylor protocol were included. All recipients were followed for at least one year. The patients answered QoL surveys of both SF-36 and Diabetes Form 2.1 at 3, 6 and 12 months after the last ICT. These scores, where higher score indicates better QoL, were compared with baseline cohort using one-way ANOVA with least significant differences post hoc tests.

Results: All scores of QoL survey at post-ICT were higher or similar compared to those at pre-ICT (Figure 1). The scores of total average and physical functioning subscale in SF-36 at any time points of post-ICT were significantly higher than baseline (*P < 0.05). Marginally significant improvements were found in general health perceptions subscale in SF-36 and symptom index in Diabetes Form 2.1 compared to baseline (^†P = 0.05).

Conclusions: ICT with the Baylor protocol can improve the QoL especially for physical activities at one-year follow-up. Personal health perception and interference due to diabetic complication were also improved at a marginally significant level. The Baylor protocol is a feasible strategy for ICT, evidenced by the patient-reported outcome.

Figure 1. QoL scores at pre- and post-ICT with Baylor protocol.