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Presenter: M. , Takita1, ,
Authors: M. Takita1, S. Matsumoto1, M. Shimoda2, D. Chujo3, T. Itoh1, K. Sugimoto1, J.A. SoRelle4, N. Onaca5, B. Naziruddin5, M.F. Levy5
P-217
Association between the SUITO index and satisfaction with insulin therapy among islet transplant patients
M. Takita1, S. Matsumoto1, M. Shimoda2, D. Chujo3, T. Itoh1, K. Sugimoto1, J.A. SoRelle4, N. Onaca5, B. Naziruddin5, M.F. Levy5
1 Baylor Research Institute Fort Worth Campus, Islet Cell Laboratory, Fort Worth, USA; 2 Baylor University Medical Center at Dallas, Dallas, USA; 3 Baylor Institute for Immunology Research, Dallas, USA; 4 Institute of Biomedical Studies, Baylor University, Waco, USA; 5 Annette C. and Harold C. Simmons Transplant Institute, Dallas, USA
Objective: One of the aims of islet cell transplantation (ICT) is elimination of severe hypoglycemia when the patients do not become insulin independent. Previously we reported that a Secretory Unit of Islet Transplant Objects (SUITO) index of more than 10 was associated with reduced severe hypoglycemia. In this study, we assessed patients’ satisfaction with their insulin therapy based on the SUITO index.
Methods: A total of 37 QoL questionnaires from 11 islet recipients with type 1 diabetes who underwent ICTs were included. The patients answered insulin therapy satisfaction questionnaires (ITSQ) before and after ICT if they were insulin dependent. The SUITO index [fasting C-peptide (ng/mL) x 1500/(blood glucose (mg/dl) ? 63)] was calculated at the same outpatient visits that the QoL survey was administered. The scores were summarized by subscales and compared among the following three groups: pre-ICT, post-ICT time-points with SUITO index ≤ 10 and those with SUITO index>10. The higher scores indicate better satisfaction in the survey.
Results: All average scores for post-ICT with SUITO>10 were higher than the other two groups (Figure 1). The total average score and scores in subscales of glycemic control, hypoglycemic control and inconvenience of regimen in post-ICT with SUITO>10 were significantly higher than those at pre-ICT (*P under one-way ANOVA with Dunnett post-hoc test < 0.05) whereas post-ICT with SUITO ≤10 did not have any significant improvements compared with pre-ICT.
Conclusions: Islet recipients with a SUITO index>10 experience increased satisfaction from insulin injection therapy compared to pre-ICT even though they were insulin dependent. SUITO index≤10 is a reasonable benchmark for failed ICT.
Figure 1. ITSQ scores at pre- and post-ICT (mean ± S. E.).
P-217
Association between the SUITO index and satisfaction with insulin therapy among islet transplant patients
M. Takita1, S. Matsumoto1, M. Shimoda2, D. Chujo3, T. Itoh1, K. Sugimoto1, J.A. SoRelle4, N. Onaca5, B. Naziruddin5, M.F. Levy5
1 Baylor Research Institute Fort Worth Campus, Islet Cell Laboratory, Fort Worth, USA; 2 Baylor University Medical Center at Dallas, Dallas, USA; 3 Baylor Institute for Immunology Research, Dallas, USA; 4 Institute of Biomedical Studies, Baylor University, Waco, USA; 5 Annette C. and Harold C. Simmons Transplant Institute, Dallas, USA
Objective: One of the aims of islet cell transplantation (ICT) is elimination of severe hypoglycemia when the patients do not become insulin independent. Previously we reported that a Secretory Unit of Islet Transplant Objects (SUITO) index of more than 10 was associated with reduced severe hypoglycemia. In this study, we assessed patients’ satisfaction with their insulin therapy based on the SUITO index.
Methods: A total of 37 QoL questionnaires from 11 islet recipients with type 1 diabetes who underwent ICTs were included. The patients answered insulin therapy satisfaction questionnaires (ITSQ) before and after ICT if they were insulin dependent. The SUITO index [fasting C-peptide (ng/mL) x 1500/(blood glucose (mg/dl) ? 63)] was calculated at the same outpatient visits that the QoL survey was administered. The scores were summarized by subscales and compared among the following three groups: pre-ICT, post-ICT time-points with SUITO index ≤ 10 and those with SUITO index>10. The higher scores indicate better satisfaction in the survey.
Results: All average scores for post-ICT with SUITO>10 were higher than the other two groups (Figure 1). The total average score and scores in subscales of glycemic control, hypoglycemic control and inconvenience of regimen in post-ICT with SUITO>10 were significantly higher than those at pre-ICT (*P under one-way ANOVA with Dunnett post-hoc test < 0.05) whereas post-ICT with SUITO ≤10 did not have any significant improvements compared with pre-ICT.
Conclusions: Islet recipients with a SUITO index>10 experience increased satisfaction from insulin injection therapy compared to pre-ICT even though they were insulin dependent. SUITO index≤10 is a reasonable benchmark for failed ICT.
Figure 1. ITSQ scores at pre- and post-ICT (mean ± S. E.).
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