P-219

Usefulness of SUITO index for evaluation of autologous islet transplantation outcome

S. Matsumoto¹, M. Takita¹, M. Shimoda², K. Sugimoto¹, T. Itoh¹, D. Chujo³, J. SoRelle⁴, Y. Tamura⁵, A. Rahman⁵, N. Onaca⁵, B. Naziruddin⁵, M. Levy^5
1 Baylor Research Institute, Islet Cell Laboratory, Fort Worth, USA; ² Baylor University Medical Center, Dallas, USA; ³ Baylor Institute for Immunology Research, Dallas, USA; ⁴ Baylor University, Waco, USA
⁵ Baylor Regional Transplant Institute, Dallas, USA

Background: Assessing the engrafted islet mass is importantto evaluate the efficacy of islet transplantation. We demonstrated that the average SUITO indexwithin one month after allogeneic islet transplantation was an excellent predictorfor insulin independence. However, theusefulness of SUITO index for the evaluation of autologous islettransplantation outcome has not been explored.

Purpose: The purpose of this study is to assess therelationship between the SUITO index and clinical outcomes after totalpancreatectomy followed by autologous islet transplantation.

Method: We performed 27 total pancreatectomies followed byautologous islet transplantation. Allcases were divided into an insulin independence group (IIG; N=12) and an insulindependent group (IDG: N=15). The SUITOindex was calculated using the formula as follows: [fasting C-peptide(ng/ml)/fasting glucose – 63 (mg/dl)] x 1500. Average SUITO index within first month after transplantation except forday 1 and 2, maximum SUITO index and the recent SUITO index was calculated ineach case.

Results: Average SUITO index within one month wassignificantly higher in the IIG (24.6±3.4 vs. 14.9±2.0 in the IIG vs. the IDGrespectively, P<0.02). The maximumSUITO indices were 45.7±7.7 at postoperative day (POD) 113±39 in the IIG and30.1±8.1 at POD 25±8.2 in the IDG. Therewas no significant difference in the maximum SUITO index however; the IIG hadsignificantly delayed time to achieve maximum value (P<0.03). The recent SUITO indices were 36.9±6.7 at POD205±60 in the IIG and 22.8±6.1 at POD 44±12 in the IDG. There was no significant difference in therecent SUITO index however; follow up period was significantly longer in the IIG(P<0.03).

Conclusion: The average SUITO index within one month mightbe an excellent predictor for insulin independence after total pancreatectomyfollowed by autologous islet transplantation.

P-219

Usefulness of SUITO index for evaluation of autologous islet transplantation outcome

S. Matsumoto¹, M. Takita¹, M. Shimoda², K. Sugimoto¹, T. Itoh¹, D. Chujo³, J. SoRelle⁴, Y. Tamura⁵, A. Rahman⁵, N. Onaca⁵, B. Naziruddin⁵, M. Levy^5
1 Baylor Research Institute, Islet Cell Laboratory, Fort Worth, USA; ² Baylor University Medical Center, Dallas, USA; ³ Baylor Institute for Immunology Research, Dallas, USA; ⁴ Baylor University, Waco, USA
⁵ Baylor Regional Transplant Institute, Dallas, USA

Background: Assessing the engrafted islet mass is importantto evaluate the efficacy of islet transplantation. We demonstrated that the average SUITO indexwithin one month after allogeneic islet transplantation was an excellent predictorfor insulin independence. However, theusefulness of SUITO index for the evaluation of autologous islettransplantation outcome has not been explored.

Purpose: The purpose of this study is to assess therelationship between the SUITO index and clinical outcomes after totalpancreatectomy followed by autologous islet transplantation.

Method: We performed 27 total pancreatectomies followed byautologous islet transplantation. Allcases were divided into an insulin independence group (IIG; N=12) and an insulindependent group (IDG: N=15). The SUITOindex was calculated using the formula as follows: [fasting C-peptide(ng/ml)/fasting glucose – 63 (mg/dl)] x 1500. Average SUITO index within first month after transplantation except forday 1 and 2, maximum SUITO index and the recent SUITO index was calculated ineach case.

Results: Average SUITO index within one month wassignificantly higher in the IIG (24.6±3.4 vs. 14.9±2.0 in the IIG vs. the IDGrespectively, P<0.02). The maximumSUITO indices were 45.7±7.7 at postoperative day (POD) 113±39 in the IIG and30.1±8.1 at POD 25±8.2 in the IDG. Therewas no significant difference in the maximum SUITO index however; the IIG hadsignificantly delayed time to achieve maximum value (P<0.03). The recent SUITO indices were 36.9±6.7 at POD205±60 in the IIG and 22.8±6.1 at POD 44±12 in the IDG. There was no significant difference in therecent SUITO index however; follow up period was significantly longer in the IIG(P<0.03).

Conclusion: The average SUITO index within one month mightbe an excellent predictor for insulin independence after total pancreatectomyfollowed by autologous islet transplantation.