2019-2020 - TTS Education Committee’s Precision Medicine Webinar Series

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Bridging the gap between basic and translational transplant research

3.1 - Bridging the gap between basic and translational transplant research; the role of transplant biobanks

Presenter: Maria Kaisar, Rutger Ploeg, ,
Authors: Maria Kaisar, Rutger Ploeg, Göran Klintmalm

Maria Kaisar's Bio:

Dr Maria Kaisar obtained her DPhil in Transplantation Science from the University of Oxford under the supervision of Prof Ploeg. Her interests lie in basic and translational research to better understand the biological mechanisms that lead to organ injury or repair. Her collaborative work, within the National Health Service Blood and Transplant and the University of Oxford, focuses on the development of novel diagnostics of donor organ quality. Her research has the potential to increase utilization of deceased donor organs and improve long term transplantation outcomes for organ recipients. She is currently the Translational Research Coordinator for the UK Consortium of Quality in Organ Donation (QUOD) and she is a Board Member of the Basic Science Committee of the European Society of Organ Transplantation (ESOT) and a member of the TTS Educational Committee.

Rutger Ploeg's Bio:

Rutger Ploeg is Professor of Transplant Biology, Director of Clinical & Translational Research and Consultant Transplant Surgeon at the Nuffield Department of Surgical Sciences, University of Oxford.He undertakes clinical, translational and experimental research in organ donation and transplantation. He focuses on mechanisms of injury and repair to enhance donor organ quality and allow regeneration after transplantation to increase allograft function and survival. Currently, he coordinates a national consortium in the UK to investigate QUality in Organ Donation (QUOD) and a European consortium to study preservation (COPE).

Göran Klintmalm's Bio:

Dr. Goran Klintmalm is chairman and chief of the Annette C. and Harold C. Simmons Transplant Institute at Baylor University Medical Center in the Dal1as, Texas. He is past President of (ASTS) American Society of Transplant Surgeons and during that presidency; he established the Business Practice Committee of ASTS and expanded the Board from six to eight Councilors. Dr. Klintmalm has been involved with UNOS since its creation. On MPSC 1992-94, Board 1994-96. ILTS – Chair Basic Science Committee; International Society of Uterus Transplant – Vice President; DHHS – Transplant Applications Reviewer; American Surgical Association –Membership Committee.

Dr. Klintmalm received his medical degree and PhD from the Karolinska Institute in Stockholm, Sweden. He did his surgical residency in Sweden, then studied transplantation as a Fellow at the University of Colorado Health Science Center, and moved to the University of Pittsburgh Medical School with Dr. Thomas Starzl. He subsequently completed a fellowship in transplantation at the Karolinska Institute in 1983 under Dr. Carl Groth and was named acting associate professor of surgery.

Dr. Klintmalm was recruited to come to Baylor in 1984 to begin a multi-organ transplant program. The program performed its first liver transplant in December 1984 and has performed over 4,300 liver transplants and over 4,600 kidney transplants to date.

From 1995 through 2010, Dr. Klintmalm directed the Dallas Liver Transplant Program in partnership with Children’s Medical Center of Dallas. In 1997, he and his transplant team performed the world’s first extracorporeal perfusion (bridge to transplant) using a genetically altered pig liver, which allowed the patient to successfully undergo liver transplantation. In 1999, he performed the first split liver transplant in North Texas and the first adult living donor transplant in Texas in 2001. He has trained 49 transplant surgery fellows.

Dr. Klintmalm is the author of more than 450 peer-reviewed and over 80 non-peer-reviewed publications, editor of 45 textbooks chapters and 250 published abstracts. Editor of five textbooks. Together with Dr. Ronald Busuttil, he published the textbook “Transplantation of the Liver,” now in its third edition, which is the standard textbook in liver transplantation worldwide. Editorial Boards / Associate Editor/Reviewer – American Journal of Gastroenterology, Annals of Surgery, American Journal of Transplantation, New England Journal of Medicine, Liver Transplantation. Transplantation to mention a few. His research interests include liver, kidney, pancreas and small bowel transplantation, hepatobiliary surgery, immunosuppression and organ preservation. He established and has maintained the Baylor Biorepository and prospective Clinical Research Database in liver transplantation since 1985. The repository collects patients’ blood samples on protocol for life.

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