This issue brings a host of great basic science papers across tolerance and innate immunity in different settings. Very practical clinical issues are also considered in a consensus statement on perioperative fluid management and many issues in clinical liver transplantation related to immunosuppression, management of recipients with cancers and from laparoscopic masters the approach to the bile ducts in living liver transplantation. The next in the series of expert consensus statements comes from the ILTS. Kidney transplant desensitization shows a glimmer of hope in a couple of directions: ex-vivo machine perfusion is examined and techniques compared in a porcine transplant model and the hopes for monitoring urine for ejection are given another boost. Face transplantation, uterine transplantation and pancreas transplantation as well as a number of adverse event issues are also packed into this comprehensive issue.