TTS congratulates Jeremy Chapman and Manikkam Suthanthiran, on being awarded the 2022 Medawar Prize. Both laureates will present, and receive their awards, during the TTS 2022 President's Plenary, being held on Thursday, September 14, 2022 in Buenos Aires.
The Medawar Prize, named after TTS co-founder Sir Peter Medawar, is recognized as the world's highest dedicated award for the most outstanding contributions in the field of transplantation. The Medawar Prize has been awarded at each of the Society's biennial Congresses since 1990.


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Transplantation Updates

Transplantation - Week's Most Downloaded Paper

KDIGO Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation

The 2020 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation is intended to assist health care professionals worldwide who evaluate and manage potential candidates for deceased or living donor kidney transplantation. This guideline addresses general candidacy issues such as access to transplantation, patient demographic and health status factors, and immunological and psychosocial assessment.

Transplantation Direct - Week's Most Downloaded Paper

Liver Transplantation for Metastases From Solid Pseudopapillary Tumor of the Pancreas: A Case Report and Review of Literature

Organ stiffening can be caused by inflammation and fibrosis, processes that are common causes of transplant kidney dysfunction. Magnetic resonance elastography (MRE) is a contrast-free, noninvasive imaging modality that measures kidney stiffness. The objective of this study was to assess the ability of MRE to serve as a prognostic factor for renal outcomes.



Compiled by: Carlos Diaz and Hatem Amer
Editor: Enver Akalin
TTS Educational Committee started weekly Hot Off the Press in April 2020 after COVID-19 pandemic to review important articles related to COVID-19 and transplantation. The aim was to inform the TTS members important publications as early as possible and this initiate has received good feedback. We plan to continue New Hot Off The Press to cover various other topics on a weekly basis and pick up the important manuscripts published at high impact journals.

Biological pathways and comparison with biopsy signals and cellular origin of peripheral blood transcriptomic profiles during kidney allograft pathology

Elisabet Van Loon, et al.
Kidney Int. (2022) 102, 183-195. doi: 10.1016/j.kint.2022.03.026. PMID: 35526671
In this article, four European transplant centers, analyzed the molecular alterations in peripheral blood samples (pbs) taken at the time of a protocol kidney allograft biopsy (between June 2011 and August 2016). They used RNA-sequencing of a set of pbs selected for rejection and polyomavirus nephropathy (PVAN), and compared it with transcriptomics of control samples without these pathologies. In a case control study design, 384 pbs from 365 kidney recipients (~85% europeans, >90% on CNI plus steroids) were analyzed: 136 with rejection (86 ABMR and 68 TCMR, of which 18 had concomitant ABMR), 21 PVAN cases; and 227 heterogeneous control biopsies (no rejection nor PVAN). In pbs from any type of rejection, the differentially expressed genes (DEGs) showed up regulation of genes that reflect immune activation pathways (the nucleotide-binding oligomerization domain (NOD)-like receptor signaling pathway was the most up-regulated). For ABMR cases, Interferon-regulatory factors were the most activated upstream regulators whereas in TCMR cases were less specific. Interestingly, no DEG showed a significant difference between clinical (n=78) vs. subclinical (n=58) rejection. It was also compared DEGs from pbs with DEGs from 224 biopsies, and they found a consistently upregulated genes per phenotype in both, blood and biopsy. Authors conclude that peripheral blood RNASeq data in the peripheral blood reveals immune activation pathways in peripheral blood leukocytes, reflecting renal allograft pathology.

Novel retinal vascular phenotypes for the potential assessment of long-term risk in living kidney donors

Ylenia Giarratano, et al.
Kidney Int. (2022), Article in Press. July 07, 2022. doi: 10.1016/j.kint.2022.06.019. PMID: 35810879
In this research letter, a group from Edinburg explore the hypothesis that living kidney donors, without CKD or overt CVD, would have retinal microvascular changes similar to patients with CKD after kidney donation. For that, they used optical coherence tomography angiography (OCT-A) from one eye of 30 patients with CKD, 30 age and sex-matched healthy volunteers, and 30 kidney donors at the same time of day. eGFR were 96±11, 35±29, 63±16 ml/min for Control, CKD and Donor group respectively. Proteinuria and systolic blood pressure was significantly present in CKD group. They had identified two clusters of retinal features that differentiate CKD from healthy volunteers. Pre donation, Donors spanned in both clusters with most of them falling into the CKD cluster. Then they investigated how the retinal features identified changed over time in healthy controls and in kidney donors before, and following, kidney donation. Donors showed significant temporal changes in 6 of the phenotypes that were stable in controls. Interestingly, from the 6 phenotypes only one of them (increase in Foveal Avascular Zone area) showed a moderate correlation (R=0.54; P<0.03), with eGFR changes after donation. This study represents a step forward in characterizing the renal and cardiovascular consequences of living kidney donation and that these findings may contribute to asses outcomes in these population.

Just Released - IXA Newsetter - July 2022

This newsletter comes to you at a most exciting time for the field of xenotransplantation, with the world’s gaze upon the recent clinical xenotransplants and to IXA’s role as the guiding professional representative expert association. In the past 6 months, we have seen the realisation of clinical xenotransplantation as a new clinical therapy, a great step forward with several amazing achievements including the first successful pig-to-human xeno-heart transplant.

The video featured below was recorded by TTS with Muhammed Mohiuddin, Professor of Surgery Director, Program in Cardiac Xenotransplantation, University of Maryland School of Medicine detailing the pig heart xenotransplant performed in January this year.

TTS Needs Assessment Survey

Marcelo Cantarovich
TTS President

The slogan we adopted for the TTS 2022 Congress is "Committed to Access and Transparency" and as a lead-up to the Congress we have launched a new needs assessment survey which will aid TTS in developing new programs, educational material and strategies to better improve access and transparency in the field of transplantation. As a non-governmental organization in official relations with the World Health Organization (WHO) the information collected will feed into the work TTS is doing as part of our WHO collaboration.

Your support, by completing this survey, will contribute to the success of this initiative. Your answers will be kept confidential and anonymous.

The survey will take 6+ minutes and must be done from a computer or tablet.

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