Since 2017 TTS has been participating in the Transplantation Therapeutics Consortium (TTC), a program of the Critical Path Institute (https://c-path.org/programs/ttc/).
TTC is a public-private collaboration between the transplant community, including industry, academia, professional societies, and regulatory agencies. TTC’s mission is to accelerate the pace of medical product development for transplant recipients with a focus on obtaining regulatory agency endorsement of new medical products. TTS members, Roslyn Mannon and Randy Morris have been representing TTS in this forum. TTC’s initial work has been on endorsing the iBox Scoring System (Composite Biomarker Panel) for acceptance by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) as a surrogate endpoint to accelerate the pace of drug development in the field of kidney transplantation.
Glycocalyx Damage Within Human Liver Grafts Correlates With Graft Injury and Postoperative Graft Function After Orthotopic Liver TransplantationDestruction of the endothelial glycocalyx has been observed within lung and kidney grafts during ischemic organ preservation. We aimed to quantify glycocalyx damage within human liver grafts after organ preservation and correlate the results with graft injury and postoperative graft function in patients undergoing orthotopic liver transplantation (OLT).
Challenges in the Management of Kidney Allograft Herniation With a Single-stage Pedicled Anterolateral Thigh FlapWound complications are the most common surgical complication after kidney allograft transplantation. Total wound rupture exposing the entire kidney is a rare and not well-described event. We present a successful treatment of this complication in a patient admitted to our unit. A single-stage procedure was performed combining debridement and reconstruction with a pedicled anterolateral thigh flap and an iliotibial band transferring. A short literature review is performed comparing the different treatment strategies and results.