JUST RELEASED - Transplantation Direct - July 2025 Issue

The July issue of Transplantation Direct covers a wide spectrum of topics in transplantation research. Starting with kidney transplantation, we have studies on policy change effects related to the use of KDPI HCV NAT⁺ organs, surgical innovations in living organ donation, and the impact of cardiac revascularization on transplant outcomes. In liver transplantation, researchers address whether machine perfusion reduces biliary complications after DCD, and a survey measures current perceptions by surgeons regarding machine perfusion methods; also, there are reports on bioinformatics approaches to assess autophagy in ischemia reperfusion injury, on determining whether high-experience centers have better outcomes in cholangiocarcinoma patients, and on specific surgical techniques to successfully do liver transplants in non-human primates. For the lung transplant community, we have articles looking at the impact of Composite Allocation Score on waitlisting and outcomes, and there is report on analysis of molecular allograft injury profiling in different types of post-transplant lung pathologies. Small bowel transplantation is also covered, with articles on the use of 3D laparoscopic live donor ileal resection with living donation, and new approaches to improving survival in pediatric patients developing GvHD. In kidney-pancreas transplantation, eculizumab plus basiliximab/belatacept is used without CNIs to manage cases of thrombotic microangiopathy. On organ donation, we have a UK study examining eligible DBD donors proceeding via the DCD pathway. Finally, in general, the current landscape of global transplant research collaborations is investigated and summarized. Please visit our open access Transplantation Direct website for all the details on these and other publications.

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FOCiS 2025 - 25th Annual Meeting of the Federation of Clinical Immunology Societies

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Highlights from the joint TTS-ASHI-AST symposium

The joint TTS-ASHI-AST symposium, held on 24 June 2025 at FOCIS in Boston, drew an engaged audience of around 40 delegates for a lively three-hour exploration of “Evolving Cell Therapies in Transplantation – Epigenetic Modulation.” The programme traced the field’s rapid progress from basic transcriptional control of regulatory T-cells through to clinically relevant biomarkers and precision gene-editing strategies. Highlights included Andrew Wells’ demonstration that Foxp3 relies on Ikaros to safeguard Treg identity, Anita Chong’s assessment of the hurdles facing CAR-Tregs in promoting infectious tolerance, and Joanna Schaenman’s unveiling of an epigenetic CMV-risk score for lung-transplant recipients.

After a welcome coffee break, Sean Agbor-Enoh showed how tissue-of-origin signatures in cell-free DNA can sharpen graft-versus-host diagnostics, John Greenland mapped DNA-methylation fingerprints of allograft injury, and Dimitrios Wagner closed the morning by showcasing CD3ε editing, in contrast to CAR insertion, to retarget Tregs. The steady discussion, cross-disciplinary networking and clear translational focus confirmed the session’s success and underscored the value of partnership between the three societies in driving next-generation cellular therapies towards the clinic.

- (from left to right) Session speakers and moderators: Johnathan Maltzman, Dimitrios Laurin Wagner, Anita Chong, Andrew Wells, Joanna Schaenman, Sean Agbor-Enoh, John Greenland, and Elaine Reed

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Insights From Refusal Patterns for Deceased Donor Kidney Offers

The likelihood that a deceased donor kidney will be used evolves during the allocation process. Transplant centers can either decline an organ offer for a single patient or for multiple patients at the same time. We hypothesize that refusals for a single patient indicate issues with individual patients, whereas simultaneous refusals for multiple patients indicate issues with organ quality.

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Bridging the Gap: The State of Global Transplant Research Collaboration

The field of transplant research has long been recognized for its innovative approaches and international collaborations. This study aims to dissect the landscape of global collaborations within transplant research during a past decade.

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In the News

Image credit: Vertex

London woman off insulin for Type 1 diabetes after a single dose of experimental manufactured stem cells

Amanda Smith celebrates the day, August 1, nearly two years ago, when she stopped taking insulin to manage her type one diabetes, just a few months after getting a dose of experimental stem cells as part of a study.

Innovations and progress in tissue engineering theory and technology

June 20 - Tissue engineering and regenerative medicine have shown significant potential for repairing and regenerating damaged tissues and can be used to provide personalized treatment plans, with broad application prospects. This article outlines the latest advances in minimally invasive implantable biomaterials for bone regeneration and different methods of achieving osteogenesis.

3D printing breakthrough: Scientists create functional human islets for type 1 diabetes treatment

June 28 - A team of international scientists has made a major leap forward in diabetes research by successfully 3D printing functional human islets using a novel bioink. The breakthrough involved printing human islets using a customised bioink made from alginate and decellularised human pancreatic tissue.

For Heart Transplant Patients, Blood Test May Detect Rejection Earlier and More Easily

June 27 - Following a heart transplant, patients must undergo surgical biopsies so that clinicians can monitor for signs of organ rejection. A new Transplantation study in patients shows the promise of a biomarker that could allow doctors to replace these invasive biopsies with a simple blood test.

Transplanting Kidney Donor Bone Marrow, Tregs Results in Chimerism

June 27 - Inducing temporary chimerism by transplanting donor Tregs and bone marrow after kidney transplantation was successful in a phase 1 and 2a trial. The hope is that it will reduce the risk for graft loss.

Partial match parity: Increasing the donor pool for hematopoietic stem cell transplantation

June 27 - Blood cancer patients who may have previously struggled to find a donor for transplantation now have more options. A new study shows that patients achieve good outcomes with a partial match drawn from the national public registry of donors when they are treated with the immune-suppressing drug cyclophosphamide. Survival rates at one year were on par with rates seen in other studies with fully matched donors.

Mice Regenerate Ear Tissue When Vitamin A Genetic Switch is Flipped

June 27 - By flipping an evolutionarily disabled genetic switch involved in vitamin A metabolism, researchers headed by a team at the National Institute of Biological Sciences, Beijing, have enabled ear tissue regeneration in mice. The scientists, co-led by Wei Wang, PhD, and colleagues, performed a side-by-side genetic comparison between mammal species—including rabbits—that can regenerate ear tissue and those—including mice—that can’t.

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JUST RELEASED - Transplantation Direct - July 2025 Issue

Quick Question: Are You Coming to WTC 2025?

Countdown is on to WTC 2025

Get Ready

Discover and Register

WTC 2025: A Congress Unlike Any Other

Upcoming Joint Webinar Presentations | The Lancet - TTS - AST - ESOT

Upcoming Webinar Presentations

FOCiS 2025 - 25th Annual Meeting of the Federation of Clinical Immunology Societies

Highlights from the joint TTS-ASHI-AST symposium

Transplantation Journal Highlights

Transplantation Journal - Social Media Content

Transplantation Direct - Social Media Content

ITS 2025 - Early-bird Registration is Open

Join us for the 2025 International Transplantation Science meeting (ITS 2025) and connect with the leading global transplantation community!

In the News

London woman off insulin for Type 1 diabetes after a single dose of experimental manufactured stem cells

Innovations and progress in tissue engineering theory and technology

3D printing breakthrough: Scientists create functional human islets for type 1 diabetes treatment

For Heart Transplant Patients, Blood Test May Detect Rejection Earlier and More Easily

Transplanting Kidney Donor Bone Marrow, Tregs Results in Chimerism

Partial match parity: Increasing the donor pool for hematopoietic stem cell transplantation

Mice Regenerate Ear Tissue When Vitamin A Genetic Switch is Flipped

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