Transplantation Direct - November Issue

The November issue of Transplantation Direct is ready for viewing. Among the topics covered in this issue in kidney transplantation include the use of tocilizumab (anti-IL-6) to treat chronic active antibody-mediated rejection, and the personalized management of transplant outcomes using an Adjustable Graft Failure Scoring system. In living kidney transplantation, a group from Canada reports on substantial barriers that limit pre-transplant donor eligibility evaluations; from Australia, an Australian Matchability Score is introduced to better balance kidney transplant accessibility and HLA matching in deceased donor allocation. In addition, influence of the eGFR assessment method is evaluated for determining eligibility of living kidney donors. In liver transplantation, the effects of ECMO support in DCD normothermic regional perfusion situations is evaluated, there is a report on the landscape of liver utilization in the US in the current era of machine perfusion, and results from a prospective controlled trial in Australia compares duct-duct biliary anastomosis with or without transanastomotic biliary stenting. Further on the topic of transplant surgery, we have a report on an available Transplant Operative Assessment Tool that has been developed and tested to train transplant surgeons. In heart transplantation, clinicians report on successful post-transplant treatment of Chagas disease after transplantation of a Trypanosoma cruzi false negative donor allograft. We appreciate your contributions, and welcome you to visit our Transplantation Direct website for these and more articles in open access.

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Direct Procurement and Perfusion Using Hypothermic Oxygenated Perfusion for DCD Cardiac Allografts in North America

Donation after circulatory death (DCD) is a viable avenue for recovery of cardiac allografts for transplantation. Previous methods have utilized direct procurement and perfusion (DPP) using commercially available normothermic perfusion systems or in situ normothermic regional perfusion. A novel portable hypothermic oxygenated perfusion device (HOPE) (XVIVO Perfusion) has been developed and is in clinical trials for preservation of cardiac allografts. Here, we report the first North American experience using a HOPE preservation device for DPP recovery of DCD cardiac allografts and detail our experience and early patient outcomes.

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Pretransplant Immune Checkpoint Inhibitor Treatment for Intermediate-advanced Hepatocellular Carcinoma in Living Donor Liver Transplantation

The use of immune checkpoint inhibitors (ICIs) as a downstaging or bridging therapy for liver transplantation (LT) in patients with hepatocellular carcinoma (HCC) is gaining momentum. However, evidence regarding the feasibility and safety of pre-LT ICI therapy remains limited and controversial. This study presents our experience with patients with intermediate-advanced HCC who were downstaged using regimens incorporating ICIs and subsequently underwent living donor LT.

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2025 Donate Life Egypt Congress - November 12-15

TTS will be Exhibiting!

Join us for the International Transplant Congress of Donate Life Egypt (DLE 2025) and be part of one of the leading global meetings in transplantation!

Donate Life Egypt (DLE) represents all professionals involved in transplantation in Egypt. It includes surgeons, hepatologists, nephrologists, anesthetists, pediatricians, radiologists, pathologists, specialists in infectious diseases, pharmacists, nutritionists, transplant coordinators and nurses. DLE is the professional voice of organ transplantation in Egypt providing leadership, representation, and guidance for the benefit of our patients.

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SPLIT 2026 Call of Abstracts & TTS Scientific Travel Awards

Submissions Open: November 18, 2025 - January 15, 2026

The Society of Pediatric Liver Transplantation (SPLIT) is inviting you to their 30th Annual Meeting, taking place April 23–24, 2026, in San Francisco, California.

We are seeking abstract submissions—especially from trainees, junior faculty, and multidisciplinary team members, as well as from experienced researchers, clinicians, and practitioners in the field.

Whether you are an abstract submitter or not, please visit our Awards page to explore available grants that can help you attend the meeting.

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Asian Transplantation Week 2025 (ATW 2025) - November 20-22

Since its international expansion in 2016, ATW has continued to evolve as a leading platform for transplantation professionals across the Asia-Pacific region. Each year, the congress has seen remarkable growth both in scale and in the quality of its scientific content.

This year, under the theme “Together for Innovation: Breaking Boundaries in Asian Transplantation” ATW 2025 is set to offer a dynamic and forward-looking scientific program. It will bring together global experts to share emerging insights, debate pressing challenges, and foster meaningful dialogue across diverse areas of transplantation.

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