The Transplantation Science Committee (TSC) of The Transplantation Society (TTS) announces 2 new prestigious prizes to be awarded annually to the best basic science and translational science published in Transplantation.
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Submitted by Dr Andrea Schlegel, Editorial Fellow, Transplantation.
Transplant Site Influences the Immune Response After Islet Transplantation: Bone Marrow Versus Liver.
Cantarelli E, Citro A, Pellegrini S, et al.
Transplantation. 2017;101: 1046–1055
Catarelli and coworkers have recently shown that the bone marrow (BM) may represent a valid alternative site for islet infusion. Here, the authors characterized the immune response directed to islet cells transplanted into 2 different sites: the bone marrow (BM) or the liver. The authors used a preclinical mouse model with or without immunosuppression. Mice had been treated with tacrolimus and mycophenolate mofetil, anti-CD3, or a combination of those immunosuppressants. Moreover, the authors tested different histocompatibility differences in addition to a single antigen-mismatched mouse model (C57BL/6 RIP-GP in C57BL/6).
In the absence of immunosuppression, the transplant site did neither impact, kinetics of alloimmune nor antigen-specific memory T cell responses. However, islets infused into the BM appeared less protected from the adaptive immune response when an immunosuppression with anti-CD3 had been applied. Overall, this study raises concerns over the possibility of using the BM as a potential site for islet cell allotransplantation.
These inspirational Games will be held in the beautiful Mediterranean port city of Málaga, Spain, from Sunday 25 June – Sunday 02 July, 2017.
Stephanie Dundas’ body was so full of other people’s DNA that even her doctors had secretly given up hope of finding a match for the five new organs needed to save her life.
Barcelona’s Vall d’Hebron Hospital successfully avoided liver transplants for four children, who suffer from the Abernethy deformity—a congenital malformation that affect one out 30,000 children—by using a brand new technology for the first time in Spain.
June 14 -Norththwestern Medicine scientists have discovered that a subset of immune cells called nonclassical monocytes (NCMs), previously unknown to reside in the lungs, play a key role in driving primary graft dysfunction (PGD), the leading cause of death after lung transplantation.
Here, we present an update on novel molecular approaches for detection of transplant rejection, focusing primarily on miRNA and microarray techniques applied to endomyocardial biopsy sample, better know as the 'molecular microscope'.
June 13 - Immediate success rates of renal transplantation (RT) procedures are generally very high. National estimates of the impact of post-operative complications, specifically, septicemia occurring during hospitalization for RT’s on outcomes is unclear. We sought, to examine the prevalence of septicemia in patients having renal transplantation procedures and to quantify the impact of septicemia on in-hospital mortality (IHM), length of stay (LOS), and hospital charges (HC)'.
June 14 - Onychomycosis (OM) is one of the commonest superficial fungal infections. Patients undergoing hemodialysis (HD) treatment and kidney transplant recipients (KTR) are considered at risk of contracting fungal infections, but the few published data do not reach the conclusion of whether they are predisposed to OM. This study aimed to determine the prevalence and etiology of OM in these patients and to determine the antifungal susceptibility profile of the isolated fungal species.
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