1011 KT with COVID-19 have been prospectively included in the Spanish Registry and followed until recovery or death. In multivariable analysis, age, pneumonia and KT performed ≤6 months before COVID-19 were predictors of death, whereas gastrointestinal symptoms were protective. Survival analysis showed significant increasing mortality risk in four subgroups according to recipient age and time after KT (age less than 65 years and posttransplant time >6 months, age <65 and time ≤6, age ≥65 and time greater than 6 and age ≥65 and time ≤6): mortality rates were, respectively, 11.3%, 24.5%, 35.4% and 54.5% (p<.001). Patients were significantly younger, presented less pneumonia and received less frequently specific anti-COVID-19 treatment in the second wave (July-December) than in the first one (March-June). Overall mortality was lower in the second wave (15.1 vs. 27.4%, p<.001), but similar in critical patients (66.7% vs. 58.1%, p=.29).